Role of protein kinase Cδ in dopaminergic neurotoxic events

Eun Joo Shin, Young Gwang Hwang, Naveen Sharma, Hai Quyen Tran, Duy Khanh Dang, Choon Gon Jang, Ji Hoon Jeong, Seung Yeol Nah, Toshitaka Nabeshima, Hyoung Chun Kim

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The pro-apoptotic role of Protein kinase Cδ (PKCδ), a member of the novel PKC subfamily, has been well-documented in various pathological conditions. In the central nervous system, the possible role of PKCδ has been studied, mainly in the condition of dopaminergic loss. It has been suggested that the phosphorylation of PKCδ at tyrosine 311 residue (Tyr 311 ) by redox-sensitive Src family kinases (SFKs) is critical for the caspase-3-mediated proteolytic cleavage, which produces the constitutively active cleaved form of PKCδ. Mitochondrial translocation of cleaved PKCδ has been suggested to facilitate mitochondria-derived apoptosis and oxidative burdens. Moreover, it has been suggested that PKCδ contribute to neuroinflammation through the transformation of microglia into the pro-inflammatory M1 phenotype and the assembly of membrane NADPH oxidase in dopaminergic impairments. Interestingly, mitochondrial respiratory chain inhibitors or neuroinflammogens have shown to induce PKCδ activation in dopaminergic systems. Thus, PKCδ activation may be one of the pivotal causes of neuropathologic events, and could amplify these processes further in a positive feedback manner. Furthermore, PKCδ may play an intermediary role in connecting each neuropathologic event. This review affords insight into the role of PKCδ in various dopaminergic neurotoxic models, which could provide a potential target for mitigating dopaminergic neurotoxicity.

Original languageEnglish
Pages (from-to)254-261
Number of pages8
JournalFood and Chemical Toxicology
Volume121
DOIs
Publication statusPublished - 01-11-2018

Fingerprint

protein kinase C
Protein Kinase C
Chemical activation
Apoptosis Regulatory Proteins
Phosphorylation
Mitochondria
neurotoxicity
src-Family Kinases
NADPH Oxidase
electron transport chain
neuroglia
Microglia
Neurology
caspase-3
Electron Transport
Caspase 3
Oxidation-Reduction
central nervous system
Tyrosine
tyrosine

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

Shin, E. J., Hwang, Y. G., Sharma, N., Tran, H. Q., Dang, D. K., Jang, C. G., ... Kim, H. C. (2018). Role of protein kinase Cδ in dopaminergic neurotoxic events. Food and Chemical Toxicology, 121, 254-261. https://doi.org/10.1016/j.fct.2018.09.005
Shin, Eun Joo ; Hwang, Young Gwang ; Sharma, Naveen ; Tran, Hai Quyen ; Dang, Duy Khanh ; Jang, Choon Gon ; Jeong, Ji Hoon ; Nah, Seung Yeol ; Nabeshima, Toshitaka ; Kim, Hyoung Chun. / Role of protein kinase Cδ in dopaminergic neurotoxic events. In: Food and Chemical Toxicology. 2018 ; Vol. 121. pp. 254-261.
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abstract = "The pro-apoptotic role of Protein kinase Cδ (PKCδ), a member of the novel PKC subfamily, has been well-documented in various pathological conditions. In the central nervous system, the possible role of PKCδ has been studied, mainly in the condition of dopaminergic loss. It has been suggested that the phosphorylation of PKCδ at tyrosine 311 residue (Tyr 311 ) by redox-sensitive Src family kinases (SFKs) is critical for the caspase-3-mediated proteolytic cleavage, which produces the constitutively active cleaved form of PKCδ. Mitochondrial translocation of cleaved PKCδ has been suggested to facilitate mitochondria-derived apoptosis and oxidative burdens. Moreover, it has been suggested that PKCδ contribute to neuroinflammation through the transformation of microglia into the pro-inflammatory M1 phenotype and the assembly of membrane NADPH oxidase in dopaminergic impairments. Interestingly, mitochondrial respiratory chain inhibitors or neuroinflammogens have shown to induce PKCδ activation in dopaminergic systems. Thus, PKCδ activation may be one of the pivotal causes of neuropathologic events, and could amplify these processes further in a positive feedback manner. Furthermore, PKCδ may play an intermediary role in connecting each neuropathologic event. This review affords insight into the role of PKCδ in various dopaminergic neurotoxic models, which could provide a potential target for mitigating dopaminergic neurotoxicity.",
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Shin, EJ, Hwang, YG, Sharma, N, Tran, HQ, Dang, DK, Jang, CG, Jeong, JH, Nah, SY, Nabeshima, T & Kim, HC 2018, 'Role of protein kinase Cδ in dopaminergic neurotoxic events', Food and Chemical Toxicology, vol. 121, pp. 254-261. https://doi.org/10.1016/j.fct.2018.09.005

Role of protein kinase Cδ in dopaminergic neurotoxic events. / Shin, Eun Joo; Hwang, Young Gwang; Sharma, Naveen; Tran, Hai Quyen; Dang, Duy Khanh; Jang, Choon Gon; Jeong, Ji Hoon; Nah, Seung Yeol; Nabeshima, Toshitaka; Kim, Hyoung Chun.

In: Food and Chemical Toxicology, Vol. 121, 01.11.2018, p. 254-261.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Role of protein kinase Cδ in dopaminergic neurotoxic events

AU - Shin, Eun Joo

AU - Hwang, Young Gwang

AU - Sharma, Naveen

AU - Tran, Hai Quyen

AU - Dang, Duy Khanh

AU - Jang, Choon Gon

AU - Jeong, Ji Hoon

AU - Nah, Seung Yeol

AU - Nabeshima, Toshitaka

AU - Kim, Hyoung Chun

PY - 2018/11/1

Y1 - 2018/11/1

N2 - The pro-apoptotic role of Protein kinase Cδ (PKCδ), a member of the novel PKC subfamily, has been well-documented in various pathological conditions. In the central nervous system, the possible role of PKCδ has been studied, mainly in the condition of dopaminergic loss. It has been suggested that the phosphorylation of PKCδ at tyrosine 311 residue (Tyr 311 ) by redox-sensitive Src family kinases (SFKs) is critical for the caspase-3-mediated proteolytic cleavage, which produces the constitutively active cleaved form of PKCδ. Mitochondrial translocation of cleaved PKCδ has been suggested to facilitate mitochondria-derived apoptosis and oxidative burdens. Moreover, it has been suggested that PKCδ contribute to neuroinflammation through the transformation of microglia into the pro-inflammatory M1 phenotype and the assembly of membrane NADPH oxidase in dopaminergic impairments. Interestingly, mitochondrial respiratory chain inhibitors or neuroinflammogens have shown to induce PKCδ activation in dopaminergic systems. Thus, PKCδ activation may be one of the pivotal causes of neuropathologic events, and could amplify these processes further in a positive feedback manner. Furthermore, PKCδ may play an intermediary role in connecting each neuropathologic event. This review affords insight into the role of PKCδ in various dopaminergic neurotoxic models, which could provide a potential target for mitigating dopaminergic neurotoxicity.

AB - The pro-apoptotic role of Protein kinase Cδ (PKCδ), a member of the novel PKC subfamily, has been well-documented in various pathological conditions. In the central nervous system, the possible role of PKCδ has been studied, mainly in the condition of dopaminergic loss. It has been suggested that the phosphorylation of PKCδ at tyrosine 311 residue (Tyr 311 ) by redox-sensitive Src family kinases (SFKs) is critical for the caspase-3-mediated proteolytic cleavage, which produces the constitutively active cleaved form of PKCδ. Mitochondrial translocation of cleaved PKCδ has been suggested to facilitate mitochondria-derived apoptosis and oxidative burdens. Moreover, it has been suggested that PKCδ contribute to neuroinflammation through the transformation of microglia into the pro-inflammatory M1 phenotype and the assembly of membrane NADPH oxidase in dopaminergic impairments. Interestingly, mitochondrial respiratory chain inhibitors or neuroinflammogens have shown to induce PKCδ activation in dopaminergic systems. Thus, PKCδ activation may be one of the pivotal causes of neuropathologic events, and could amplify these processes further in a positive feedback manner. Furthermore, PKCδ may play an intermediary role in connecting each neuropathologic event. This review affords insight into the role of PKCδ in various dopaminergic neurotoxic models, which could provide a potential target for mitigating dopaminergic neurotoxicity.

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Shin EJ, Hwang YG, Sharma N, Tran HQ, Dang DK, Jang CG et al. Role of protein kinase Cδ in dopaminergic neurotoxic events. Food and Chemical Toxicology. 2018 Nov 1;121:254-261. https://doi.org/10.1016/j.fct.2018.09.005