TY - JOUR
T1 - Role of sex hormones in sex-dependent differences in phencyclidine-induced stereotyped behaviors in rats
AU - Nabeshima, Toshitaka
AU - Yamaguchi, Kazumasa
AU - Furukawa, Hiroshi
AU - Kameyama, Tsutomu
N1 - Funding Information:
This work was supported in part by grant No. 57570089 from the Ministry of Education, Science and Culture, Japan to TN.
PY - 1984/10/15
Y1 - 1984/10/15
N2 - This study was designed to assess the contribution of male and female sex hormones to sex-dependent differences in phencyclidine (PCP)-induced stereotyped behaviors. Female rats appeared to be more sensitive to PCP than were male rats as evidenced by stereotyped behaviors. Chronic testosterone treatment and ovariectomy decreased the susceptibility to PCP but increased the efficiency of hepatic drug metabolizing systems in female rats. On the contrary, an increased sensitivity to PCP and a decreased efficiency of hepatic drug metabolizing systems in male rats resulted from chronic treatment with estradiol and castration. It appears from these results that the male and female sex hormones are responsible for sex-dependent differences in PCP-induced stereotyped behaviors by means of changes in the metabolism of PCP.
AB - This study was designed to assess the contribution of male and female sex hormones to sex-dependent differences in phencyclidine (PCP)-induced stereotyped behaviors. Female rats appeared to be more sensitive to PCP than were male rats as evidenced by stereotyped behaviors. Chronic testosterone treatment and ovariectomy decreased the susceptibility to PCP but increased the efficiency of hepatic drug metabolizing systems in female rats. On the contrary, an increased sensitivity to PCP and a decreased efficiency of hepatic drug metabolizing systems in male rats resulted from chronic treatment with estradiol and castration. It appears from these results that the male and female sex hormones are responsible for sex-dependent differences in PCP-induced stereotyped behaviors by means of changes in the metabolism of PCP.
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U2 - 10.1016/0014-2999(84)90610-1
DO - 10.1016/0014-2999(84)90610-1
M3 - Article
C2 - 6542525
AN - SCOPUS:0021144742
SN - 0014-2999
VL - 105
SP - 197
EP - 206
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3-4
ER -