Role of 123l-BMlPP and serum B-type natriuretic peptide for the evaluation of patients with heart failure

Shankar Kumar Biswas Dr., Masayoshi Sarai, Hiroshi Toyama, Akira Yamada, Hiroto Harigaya, Hiroyuki Naruse, Hitoshi Hishida, Yukio Ozaki

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Abstract

Introduction Myocardial scintigraphy with 123I-15-(p-iodophenyl)-3-methyl pentadecanoic acid ( 123I-BMIPP) is used to evaluate impaired fatty acid metabolism. B-type natriuretic peptide (BNP), which is secreted by the ventricular myocardium on stretching and/or pressure overload, is a useful cardiac biomarker. This study aimed to evaluate the usefulness of 123I-BMIPP imaging and serum BNP levels in patients with heart failure (HF). Methods 113 patients with HF were enrolled. There were 68 patients with ischaemic heart disease (IHD) and 22 with overt HF. Cardiac scintigraphy was performed 7 ± 3 days after admission, and heart-to-mediastinum (H/M) count ratios on early and delayed images and washout rates (WR) of 123I-BMIPP were recorded. Serum BNP levels were recorded on the day of 123I-BMIPP imaging. The ejection fraction (EF) was calculated just before cardiac scintigraphy using conventional echocardiography. Resu lts The mean BNP level and EF were 282 pg/mL and 47%, respectively, with significant correlation between them. The mean H/M count ratios on early and delayed images were 2.29 and 1.93, respectively, showing significant positive correlations with EF (r = 0.31, p = 0.0006). The WR was significantly correlated with EF (r = 0.36, p < 0.0001) and BNP levels (r = 0.33, p = 0.003), and mean WR was significantly higher in patients with overt HF compared to those without (p < 0.001). Patients with IHD had significantly higher EFs than those with non-IHD (p = 0.03). Conclusion The evaluation of impaired myocardial metabolism using 123I-BMIPP scintigraphy and serum BNP levels appears to be useful for the evaluation of severity of HF.

Original languageEnglish
Pages (from-to)398-402
Number of pages5
JournalSingapore Medical Journal
Volume53
Issue number6
Publication statusPublished - 01-06-2012

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Brain Natriuretic Peptide
Heart Failure
Serum
Radionuclide Imaging
Mediastinum
Myocardial Ischemia
Myocardial Perfusion Imaging
Echocardiography
Heart Diseases
Myocardium
Fatty Acids
Biomarkers
iodofiltic acid
Pressure

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Biswas Dr., Shankar Kumar ; Sarai, Masayoshi ; Toyama, Hiroshi ; Yamada, Akira ; Harigaya, Hiroto ; Naruse, Hiroyuki ; Hishida, Hitoshi ; Ozaki, Yukio. / Role of 123l-BMlPP and serum B-type natriuretic peptide for the evaluation of patients with heart failure. In: Singapore Medical Journal. 2012 ; Vol. 53, No. 6. pp. 398-402.
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abstract = "Introduction Myocardial scintigraphy with 123I-15-(p-iodophenyl)-3-methyl pentadecanoic acid ( 123I-BMIPP) is used to evaluate impaired fatty acid metabolism. B-type natriuretic peptide (BNP), which is secreted by the ventricular myocardium on stretching and/or pressure overload, is a useful cardiac biomarker. This study aimed to evaluate the usefulness of 123I-BMIPP imaging and serum BNP levels in patients with heart failure (HF). Methods 113 patients with HF were enrolled. There were 68 patients with ischaemic heart disease (IHD) and 22 with overt HF. Cardiac scintigraphy was performed 7 ± 3 days after admission, and heart-to-mediastinum (H/M) count ratios on early and delayed images and washout rates (WR) of 123I-BMIPP were recorded. Serum BNP levels were recorded on the day of 123I-BMIPP imaging. The ejection fraction (EF) was calculated just before cardiac scintigraphy using conventional echocardiography. Resu lts The mean BNP level and EF were 282 pg/mL and 47{\%}, respectively, with significant correlation between them. The mean H/M count ratios on early and delayed images were 2.29 and 1.93, respectively, showing significant positive correlations with EF (r = 0.31, p = 0.0006). The WR was significantly correlated with EF (r = 0.36, p < 0.0001) and BNP levels (r = 0.33, p = 0.003), and mean WR was significantly higher in patients with overt HF compared to those without (p < 0.001). Patients with IHD had significantly higher EFs than those with non-IHD (p = 0.03). Conclusion The evaluation of impaired myocardial metabolism using 123I-BMIPP scintigraphy and serum BNP levels appears to be useful for the evaluation of severity of HF.",
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Role of 123l-BMlPP and serum B-type natriuretic peptide for the evaluation of patients with heart failure. / Biswas Dr., Shankar Kumar; Sarai, Masayoshi; Toyama, Hiroshi; Yamada, Akira; Harigaya, Hiroto; Naruse, Hiroyuki; Hishida, Hitoshi; Ozaki, Yukio.

In: Singapore Medical Journal, Vol. 53, No. 6, 01.06.2012, p. 398-402.

Research output: Contribution to journalArticle

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T1 - Role of 123l-BMlPP and serum B-type natriuretic peptide for the evaluation of patients with heart failure

AU - Biswas Dr., Shankar Kumar

AU - Sarai, Masayoshi

AU - Toyama, Hiroshi

AU - Yamada, Akira

AU - Harigaya, Hiroto

AU - Naruse, Hiroyuki

AU - Hishida, Hitoshi

AU - Ozaki, Yukio

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Introduction Myocardial scintigraphy with 123I-15-(p-iodophenyl)-3-methyl pentadecanoic acid ( 123I-BMIPP) is used to evaluate impaired fatty acid metabolism. B-type natriuretic peptide (BNP), which is secreted by the ventricular myocardium on stretching and/or pressure overload, is a useful cardiac biomarker. This study aimed to evaluate the usefulness of 123I-BMIPP imaging and serum BNP levels in patients with heart failure (HF). Methods 113 patients with HF were enrolled. There were 68 patients with ischaemic heart disease (IHD) and 22 with overt HF. Cardiac scintigraphy was performed 7 ± 3 days after admission, and heart-to-mediastinum (H/M) count ratios on early and delayed images and washout rates (WR) of 123I-BMIPP were recorded. Serum BNP levels were recorded on the day of 123I-BMIPP imaging. The ejection fraction (EF) was calculated just before cardiac scintigraphy using conventional echocardiography. Resu lts The mean BNP level and EF were 282 pg/mL and 47%, respectively, with significant correlation between them. The mean H/M count ratios on early and delayed images were 2.29 and 1.93, respectively, showing significant positive correlations with EF (r = 0.31, p = 0.0006). The WR was significantly correlated with EF (r = 0.36, p < 0.0001) and BNP levels (r = 0.33, p = 0.003), and mean WR was significantly higher in patients with overt HF compared to those without (p < 0.001). Patients with IHD had significantly higher EFs than those with non-IHD (p = 0.03). Conclusion The evaluation of impaired myocardial metabolism using 123I-BMIPP scintigraphy and serum BNP levels appears to be useful for the evaluation of severity of HF.

AB - Introduction Myocardial scintigraphy with 123I-15-(p-iodophenyl)-3-methyl pentadecanoic acid ( 123I-BMIPP) is used to evaluate impaired fatty acid metabolism. B-type natriuretic peptide (BNP), which is secreted by the ventricular myocardium on stretching and/or pressure overload, is a useful cardiac biomarker. This study aimed to evaluate the usefulness of 123I-BMIPP imaging and serum BNP levels in patients with heart failure (HF). Methods 113 patients with HF were enrolled. There were 68 patients with ischaemic heart disease (IHD) and 22 with overt HF. Cardiac scintigraphy was performed 7 ± 3 days after admission, and heart-to-mediastinum (H/M) count ratios on early and delayed images and washout rates (WR) of 123I-BMIPP were recorded. Serum BNP levels were recorded on the day of 123I-BMIPP imaging. The ejection fraction (EF) was calculated just before cardiac scintigraphy using conventional echocardiography. Resu lts The mean BNP level and EF were 282 pg/mL and 47%, respectively, with significant correlation between them. The mean H/M count ratios on early and delayed images were 2.29 and 1.93, respectively, showing significant positive correlations with EF (r = 0.31, p = 0.0006). The WR was significantly correlated with EF (r = 0.36, p < 0.0001) and BNP levels (r = 0.33, p = 0.003), and mean WR was significantly higher in patients with overt HF compared to those without (p < 0.001). Patients with IHD had significantly higher EFs than those with non-IHD (p = 0.03). Conclusion The evaluation of impaired myocardial metabolism using 123I-BMIPP scintigraphy and serum BNP levels appears to be useful for the evaluation of severity of HF.

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