Role of the renin-angiotensin system in gynecologic cancers

K. Ino, K. Shibata, E. Yamamoto, H. Kajiyama, A. Nawa, Y. Mabuchi, S. Yagi, S. Minami, Y. Tanizaki, A. Kobayashi, F. Kikkawa

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Recent studies have shown an activation of the local renin-angiotensin system (RAS) in various tumor tissues, including the abundant generation of angiotensin II (Ang II) by angiotensin-converting enzyme (ACE) and the upregulation of angiotensin II type 1 receptor (AT1R) expression. Thus, considerable attention has been paid not only to the role of the RAS in cancer progression, but also to the blockade of RAS as a new approach to the treatment of human cancer. There is increasing evidence that the Ang II-AT1R pathway is involved in tumor growth, angiogenesis and metastasis in various experimental animal models, suggesting the therapeutic potential of an ACE inhibitor and AT1R blocker. In addition, specific Ang II-degrading enzymes are also expressed in tumors and play a regulatory role in tumor cell proliferation and invasion. This review focuses on the role of the RAS in the progression of gynecologic cancers, such as cervical cancer, endometrial cancer, ovarian cancer, and gestational choriocarcinoma. We present here the clinical potential of blocking the RAS as a novel and promising strategy for the treatment of gynecologic cancers.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalCurrent Cancer Drug Targets
Volume11
Issue number4
DOIs
Publication statusPublished - 01-06-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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  • Cite this

    Ino, K., Shibata, K., Yamamoto, E., Kajiyama, H., Nawa, A., Mabuchi, Y., Yagi, S., Minami, S., Tanizaki, Y., Kobayashi, A., & Kikkawa, F. (2011). Role of the renin-angiotensin system in gynecologic cancers. Current Cancer Drug Targets, 11(4), 405-411. https://doi.org/10.2174/156800911795538057