Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain

Itaru Imayoshi, Masayuki Sakamoto, Toshiyuki Ohtsuka, Keizo Takao, Tsuyoshi Miyakawa, Masahiro Yamaguchi, Kensaku Mori, Toshio Ikeda, Shigeyoshi Itohara, Ryoichiro Kageyama

Research output: Contribution to journalArticle

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Abstract

Neurogenesis occurs continuously in the forebrain of adult mammals, but the functional importance of adult neurogenesis is still unclear. Here, using a genetic labeling method in adult mice, we found that continuous neurogenesis results in the replacement of the majority of granule neurons in the olfactory bulb and a substantial addition of granule neurons to the hippocampal dentate gyrus. Genetic ablation of newly formed neurons in adult mice led to a gradual decrease in the number of granule cells in the olfactory bulb, inhibition of increases in the granule cell number in the dentate gyrus and impairment of behaviors in contextual and spatial memory, which are known to depend on hippocampus. These results suggest that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory.

Original languageEnglish
Pages (from-to)1153-1161
Number of pages9
JournalNature Neuroscience
Volume11
Issue number10
DOIs
Publication statusPublished - 01-10-2008

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Neurogenesis
Prosencephalon
Olfactory Bulb
Dentate Gyrus
Neurons
Cell Count
Parahippocampal Gyrus
Interneurons
Mammals
Hippocampus
Maintenance

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., ... Kageyama, R. (2008). Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neuroscience, 11(10), 1153-1161. https://doi.org/10.1038/nn.2185
Imayoshi, Itaru ; Sakamoto, Masayuki ; Ohtsuka, Toshiyuki ; Takao, Keizo ; Miyakawa, Tsuyoshi ; Yamaguchi, Masahiro ; Mori, Kensaku ; Ikeda, Toshio ; Itohara, Shigeyoshi ; Kageyama, Ryoichiro. / Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. In: Nature Neuroscience. 2008 ; Vol. 11, No. 10. pp. 1153-1161.
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Imayoshi, I, Sakamoto, M, Ohtsuka, T, Takao, K, Miyakawa, T, Yamaguchi, M, Mori, K, Ikeda, T, Itohara, S & Kageyama, R 2008, 'Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain', Nature Neuroscience, vol. 11, no. 10, pp. 1153-1161. https://doi.org/10.1038/nn.2185

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. / Imayoshi, Itaru; Sakamoto, Masayuki; Ohtsuka, Toshiyuki; Takao, Keizo; Miyakawa, Tsuyoshi; Yamaguchi, Masahiro; Mori, Kensaku; Ikeda, Toshio; Itohara, Shigeyoshi; Kageyama, Ryoichiro.

In: Nature Neuroscience, Vol. 11, No. 10, 01.10.2008, p. 1153-1161.

Research output: Contribution to journalArticle

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