Roles of matrix metalloproteinases and their targets in epileptogenesis and seizures

Hiroyuki Mizoguchi, Kiyofumi Yamada

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which together regulate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathological conditions. Recent studies have suggested that prolonged seizures are associated with high MMP levels in serum and neural tissues, and certain extracellular macromolecule targets may influence the pathogenesis of epilepsy and seizure. In this review, we discuss the roles of MMP activation in animal models of epilepsy.

Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalClinical Psychopharmacology and Neuroscience
Volume11
Issue number2
DOIs
Publication statusPublished - 08-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Pharmacology (medical)

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