TY - JOUR
T1 - Roles of microRNAs and RNA-binding proteins in the regulation of colorectal cancer stem cells
AU - Mukohyama, Junko
AU - Shimono, Yohei
AU - Minami, Hironobu
AU - Kakeji, Yoshihiro
AU - Suzuki, Akira
N1 - Funding Information:
Acknowledgments: This work was supported by: (1) grants-in-aid from the Japan Society for the Promotion of Science (JSPS KAKENHI) 17K16555 (to Junko Mukohyama), 15K14381 (to Yohei Shimono); (2) Japan-Belgium Research Cooperative Program from the Japan Society for the Promotion of Science (to Yohei Shimono); (3) a grant from the Japan Foundation for Applied Enzymology (to Yohei Shimono); (4) a grant from the Itoh-Chubei Foundation (to Yohei Shimono); (5) an extramural collaborative research grant of Cancer Research Institute, Kanazawa University (to Yohei Shimono); (6) Postdoctoral Fellowship from the Uehara Memorial Foundation (to Junko Mukohyama); (7) Yasui Medical Scholarship for the Japanese Association of University Women (to Junko Mukohyama); (8) Research award for Young Scientist from the Japanese Society of Gastroenterological Carcinogenesis (to Junko Mukohyama).
Publisher Copyright:
© 2017 by the authors.
PY - 2017/10/24
Y1 - 2017/10/24
N2 - Colorectal cancer stem cells (CSCs) are responsible for the initiation, progression and metastasis of human colorectal cancers, and have been characterized by the expression of cell surface markers, such as CD44, CD133, CD166 and LGR5. MicroRNAs (miRNAs) are differentially expressed between CSCs and non-tumorigenic cancer cells, and play important roles in the maintenance and regulation of stem cell properties of CSCs. RNA binding proteins (RBPs) are emerging epigenetic regulators of various RNA processing events, such as splicing, localization, stabilization and translation, and can regulate various types of stem cells. In this review, we summarize current evidences on the roles of miRNA and RBPs in the regulation of colorectal CSCs. Understanding the epigenetic regulation of human colorectal CSCs will help to develop biomarkers for colorectal cancers and to identify targets for CSC-targeting therapies.
AB - Colorectal cancer stem cells (CSCs) are responsible for the initiation, progression and metastasis of human colorectal cancers, and have been characterized by the expression of cell surface markers, such as CD44, CD133, CD166 and LGR5. MicroRNAs (miRNAs) are differentially expressed between CSCs and non-tumorigenic cancer cells, and play important roles in the maintenance and regulation of stem cell properties of CSCs. RNA binding proteins (RBPs) are emerging epigenetic regulators of various RNA processing events, such as splicing, localization, stabilization and translation, and can regulate various types of stem cells. In this review, we summarize current evidences on the roles of miRNA and RBPs in the regulation of colorectal CSCs. Understanding the epigenetic regulation of human colorectal CSCs will help to develop biomarkers for colorectal cancers and to identify targets for CSC-targeting therapies.
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U2 - 10.3390/cancers9100143
DO - 10.3390/cancers9100143
M3 - Review article
AN - SCOPUS:85032590318
VL - 9
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 10
M1 - 143
ER -