TY - JOUR
T1 - Roles of microRNAs and RNA-binding proteins in the regulation of colorectal cancer stem cells
AU - Mukohyama, Junko
AU - Shimono, Yohei
AU - Minami, Hironobu
AU - Kakeji, Yoshihiro
AU - Suzuki, Akira
N1 - Publisher Copyright:
© 2017 by the authors.
PY - 2017/10/24
Y1 - 2017/10/24
N2 - Colorectal cancer stem cells (CSCs) are responsible for the initiation, progression and metastasis of human colorectal cancers, and have been characterized by the expression of cell surface markers, such as CD44, CD133, CD166 and LGR5. MicroRNAs (miRNAs) are differentially expressed between CSCs and non-tumorigenic cancer cells, and play important roles in the maintenance and regulation of stem cell properties of CSCs. RNA binding proteins (RBPs) are emerging epigenetic regulators of various RNA processing events, such as splicing, localization, stabilization and translation, and can regulate various types of stem cells. In this review, we summarize current evidences on the roles of miRNA and RBPs in the regulation of colorectal CSCs. Understanding the epigenetic regulation of human colorectal CSCs will help to develop biomarkers for colorectal cancers and to identify targets for CSC-targeting therapies.
AB - Colorectal cancer stem cells (CSCs) are responsible for the initiation, progression and metastasis of human colorectal cancers, and have been characterized by the expression of cell surface markers, such as CD44, CD133, CD166 and LGR5. MicroRNAs (miRNAs) are differentially expressed between CSCs and non-tumorigenic cancer cells, and play important roles in the maintenance and regulation of stem cell properties of CSCs. RNA binding proteins (RBPs) are emerging epigenetic regulators of various RNA processing events, such as splicing, localization, stabilization and translation, and can regulate various types of stem cells. In this review, we summarize current evidences on the roles of miRNA and RBPs in the regulation of colorectal CSCs. Understanding the epigenetic regulation of human colorectal CSCs will help to develop biomarkers for colorectal cancers and to identify targets for CSC-targeting therapies.
KW - Cancer stem cell
KW - Colorectal cancer
KW - MicroRNA
KW - RNA binding protein
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U2 - 10.3390/cancers9100143
DO - 10.3390/cancers9100143
M3 - Review article
AN - SCOPUS:85032590318
SN - 2072-6694
VL - 9
JO - Cancers
JF - Cancers
IS - 10
M1 - 143
ER -
