TY - JOUR
T1 - Roles of Rho-family GTPases in cell polarisation and directional migration
AU - Fukata, Masaki
AU - Nakagawa, Masato
AU - Kaibuchi, Kozo
N1 - Funding Information:
The authors thank A Hall (University College London, UK), HR Bourne (University of California at San Francisco, CA), and RA Firtel (University of California at San Diego, CA) for sending us recent reprints of their works. We also thank Takashi Watanabe, Jun Noritake, Shinya Kuroda, Masaki Yamaga, Takako Ishii, Yuko Fukata, and the members of our laboratory for preparing the manuscript. The original work by the authors was supported by grants-in-aid for scientific research from the Ministry of Education, Science, and Culture of Japan, by grants from Novartis Foundation for the Promotion of Science and by grants from The Nitto Foundation.
PY - 2003/10
Y1 - 2003/10
N2 - Polarised cell migration is a tightly regulated process that occurs in tissue development, chemotaxis and wound healing. Rho-family GTPases, including Cdc42, Rac1 and RhoA, play a central role in establishing cell polarisation, which requires asymmetric and ordered distribution of the signalling molecules and the cytoskeleton. Recent advances reveal that Rho GTPases, together with phosphatidylinositol 3-kinase, contribute to asymmetric phosphatidylinositol 3,4,5-trisphosphate distribution via a positive-feedback loop. Phosphatidylinositol 3,4,5-trisphosphate thereby activates the signalling cascades to the cytoskeleton as a second messenger. Rho GTPases also capture and stabilise microtubules through their effectors (e.g. IQGAP1, mDia and Par6) near the cell cortex, leading to polarised cell morphology and directional cell migration. Thus, elucidation of the signal transduction cascades from receptors to Rho GTPases and, subsequently, from Rho GTPases to microtubules has begun.
AB - Polarised cell migration is a tightly regulated process that occurs in tissue development, chemotaxis and wound healing. Rho-family GTPases, including Cdc42, Rac1 and RhoA, play a central role in establishing cell polarisation, which requires asymmetric and ordered distribution of the signalling molecules and the cytoskeleton. Recent advances reveal that Rho GTPases, together with phosphatidylinositol 3-kinase, contribute to asymmetric phosphatidylinositol 3,4,5-trisphosphate distribution via a positive-feedback loop. Phosphatidylinositol 3,4,5-trisphosphate thereby activates the signalling cascades to the cytoskeleton as a second messenger. Rho GTPases also capture and stabilise microtubules through their effectors (e.g. IQGAP1, mDia and Par6) near the cell cortex, leading to polarised cell morphology and directional cell migration. Thus, elucidation of the signal transduction cascades from receptors to Rho GTPases and, subsequently, from Rho GTPases to microtubules has begun.
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U2 - 10.1016/S0955-0674(03)00097-8
DO - 10.1016/S0955-0674(03)00097-8
M3 - Review article
C2 - 14519394
AN - SCOPUS:0141533034
VL - 15
SP - 590
EP - 597
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 5
ER -