Rotavirus vaccination can be performed without viral dissemination in the neonatal intensive care unit

Hiroyuki Hiramatsu, Ryota Suzuki, Arisa Nagatani, Hiroko Boda, Masafumi Miyata, Fumihiko Hattori, Hiroki Miura, Ken Sugata, Shigeki Yamada, Satoshi Komoto, Koki Taniguchi, Masaru Ihira, Naoko Nishimura, Takao Ozaki, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background. This study was conducted to assess the transmissibility of rotavirus vaccine strains after rotavirus vaccination in a neonatal intensive care unit (NICU). Methods. Pentavalent (RV5) or monovalent (RV1) rotavirus vaccine was administered to infants admitted to the NICU. Nineteen vaccinated infants and 49 unvaccinated infants whose beds were located in close proximity to the vaccinated infants were enrolled in this study. Dissemination and fecal shedding of vaccine viruses within the NICU were examined using real-time reverse transcription-polymerase chain reaction. Results. Shedding of the vaccine strain was detected in all 19 vaccinated infants. RV5 virus shedding started 1 day after the first vaccination and persisted for 8 days after the first vaccination, and viral shedding terminated by day 5 after administration of the second RV5 dose. The kinetics of RV1 virus shedding differed among vaccinated infants. The duration of RV1 virus shedding was longer after the first vaccination than after the second vaccination. In contrast to the vaccinated infants, no vaccine virus genomes were detected in any of the stool samples collected from the 49 unvaccinated infants. Conclusions. This study is direct evidence of no transmission of rotavirus vaccine strains between vaccinated infants and unvaccinated infants in close proximity within a NICU.

Original languageEnglish
Pages (from-to)589-596
Number of pages8
JournalJournal of Infectious Diseases
Volume217
Issue number4
DOIs
Publication statusPublished - 15-02-2018

Fingerprint

Rotavirus
Neonatal Intensive Care Units
Vaccination
Virus Shedding
Rotavirus Vaccines
Vaccines
Reverse Transcription
Genome
Viruses
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Hiramatsu, Hiroyuki ; Suzuki, Ryota ; Nagatani, Arisa ; Boda, Hiroko ; Miyata, Masafumi ; Hattori, Fumihiko ; Miura, Hiroki ; Sugata, Ken ; Yamada, Shigeki ; Komoto, Satoshi ; Taniguchi, Koki ; Ihira, Masaru ; Nishimura, Naoko ; Ozaki, Takao ; Yoshikawa, Tetsushi. / Rotavirus vaccination can be performed without viral dissemination in the neonatal intensive care unit. In: Journal of Infectious Diseases. 2018 ; Vol. 217, No. 4. pp. 589-596.
@article{9681ea712b864b11828bdbe596ddac8b,
title = "Rotavirus vaccination can be performed without viral dissemination in the neonatal intensive care unit",
abstract = "Background. This study was conducted to assess the transmissibility of rotavirus vaccine strains after rotavirus vaccination in a neonatal intensive care unit (NICU). Methods. Pentavalent (RV5) or monovalent (RV1) rotavirus vaccine was administered to infants admitted to the NICU. Nineteen vaccinated infants and 49 unvaccinated infants whose beds were located in close proximity to the vaccinated infants were enrolled in this study. Dissemination and fecal shedding of vaccine viruses within the NICU were examined using real-time reverse transcription-polymerase chain reaction. Results. Shedding of the vaccine strain was detected in all 19 vaccinated infants. RV5 virus shedding started 1 day after the first vaccination and persisted for 8 days after the first vaccination, and viral shedding terminated by day 5 after administration of the second RV5 dose. The kinetics of RV1 virus shedding differed among vaccinated infants. The duration of RV1 virus shedding was longer after the first vaccination than after the second vaccination. In contrast to the vaccinated infants, no vaccine virus genomes were detected in any of the stool samples collected from the 49 unvaccinated infants. Conclusions. This study is direct evidence of no transmission of rotavirus vaccine strains between vaccinated infants and unvaccinated infants in close proximity within a NICU.",
author = "Hiroyuki Hiramatsu and Ryota Suzuki and Arisa Nagatani and Hiroko Boda and Masafumi Miyata and Fumihiko Hattori and Hiroki Miura and Ken Sugata and Shigeki Yamada and Satoshi Komoto and Koki Taniguchi and Masaru Ihira and Naoko Nishimura and Takao Ozaki and Tetsushi Yoshikawa",
year = "2018",
month = "2",
day = "15",
doi = "10.1093/infdis/jix590",
language = "English",
volume = "217",
pages = "589--596",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

Hiramatsu, H, Suzuki, R, Nagatani, A, Boda, H, Miyata, M, Hattori, F, Miura, H, Sugata, K, Yamada, S, Komoto, S, Taniguchi, K, Ihira, M, Nishimura, N, Ozaki, T & Yoshikawa, T 2018, 'Rotavirus vaccination can be performed without viral dissemination in the neonatal intensive care unit', Journal of Infectious Diseases, vol. 217, no. 4, pp. 589-596. https://doi.org/10.1093/infdis/jix590

Rotavirus vaccination can be performed without viral dissemination in the neonatal intensive care unit. / Hiramatsu, Hiroyuki; Suzuki, Ryota; Nagatani, Arisa; Boda, Hiroko; Miyata, Masafumi; Hattori, Fumihiko; Miura, Hiroki; Sugata, Ken; Yamada, Shigeki; Komoto, Satoshi; Taniguchi, Koki; Ihira, Masaru; Nishimura, Naoko; Ozaki, Takao; Yoshikawa, Tetsushi.

In: Journal of Infectious Diseases, Vol. 217, No. 4, 15.02.2018, p. 589-596.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rotavirus vaccination can be performed without viral dissemination in the neonatal intensive care unit

AU - Hiramatsu, Hiroyuki

AU - Suzuki, Ryota

AU - Nagatani, Arisa

AU - Boda, Hiroko

AU - Miyata, Masafumi

AU - Hattori, Fumihiko

AU - Miura, Hiroki

AU - Sugata, Ken

AU - Yamada, Shigeki

AU - Komoto, Satoshi

AU - Taniguchi, Koki

AU - Ihira, Masaru

AU - Nishimura, Naoko

AU - Ozaki, Takao

AU - Yoshikawa, Tetsushi

PY - 2018/2/15

Y1 - 2018/2/15

N2 - Background. This study was conducted to assess the transmissibility of rotavirus vaccine strains after rotavirus vaccination in a neonatal intensive care unit (NICU). Methods. Pentavalent (RV5) or monovalent (RV1) rotavirus vaccine was administered to infants admitted to the NICU. Nineteen vaccinated infants and 49 unvaccinated infants whose beds were located in close proximity to the vaccinated infants were enrolled in this study. Dissemination and fecal shedding of vaccine viruses within the NICU were examined using real-time reverse transcription-polymerase chain reaction. Results. Shedding of the vaccine strain was detected in all 19 vaccinated infants. RV5 virus shedding started 1 day after the first vaccination and persisted for 8 days after the first vaccination, and viral shedding terminated by day 5 after administration of the second RV5 dose. The kinetics of RV1 virus shedding differed among vaccinated infants. The duration of RV1 virus shedding was longer after the first vaccination than after the second vaccination. In contrast to the vaccinated infants, no vaccine virus genomes were detected in any of the stool samples collected from the 49 unvaccinated infants. Conclusions. This study is direct evidence of no transmission of rotavirus vaccine strains between vaccinated infants and unvaccinated infants in close proximity within a NICU.

AB - Background. This study was conducted to assess the transmissibility of rotavirus vaccine strains after rotavirus vaccination in a neonatal intensive care unit (NICU). Methods. Pentavalent (RV5) or monovalent (RV1) rotavirus vaccine was administered to infants admitted to the NICU. Nineteen vaccinated infants and 49 unvaccinated infants whose beds were located in close proximity to the vaccinated infants were enrolled in this study. Dissemination and fecal shedding of vaccine viruses within the NICU were examined using real-time reverse transcription-polymerase chain reaction. Results. Shedding of the vaccine strain was detected in all 19 vaccinated infants. RV5 virus shedding started 1 day after the first vaccination and persisted for 8 days after the first vaccination, and viral shedding terminated by day 5 after administration of the second RV5 dose. The kinetics of RV1 virus shedding differed among vaccinated infants. The duration of RV1 virus shedding was longer after the first vaccination than after the second vaccination. In contrast to the vaccinated infants, no vaccine virus genomes were detected in any of the stool samples collected from the 49 unvaccinated infants. Conclusions. This study is direct evidence of no transmission of rotavirus vaccine strains between vaccinated infants and unvaccinated infants in close proximity within a NICU.

UR - http://www.scopus.com/inward/record.url?scp=85044481872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044481872&partnerID=8YFLogxK

U2 - 10.1093/infdis/jix590

DO - 10.1093/infdis/jix590

M3 - Article

C2 - 29165657

AN - SCOPUS:85044481872

VL - 217

SP - 589

EP - 596

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -