Rotavirus vaccine strain transmission by vaccinated infants in the foster home

Hiroki Miura, Yoshiki Kawamura, Ken Sugata, Nozomi Koshiyama, Akiko Yoshikawa, Satoshi Komoto, Koki Taniguchi, Masaru Ihira, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Previous studies have demonstrated the transmission of rotavirus vaccine strains from vaccinated children to nonvaccinated siblings. We sought to fully elucidate the safety of rotavirus (RV) vaccination in closed contact circumstance, such as the foster home for future assessment of the vaccine safety in an neonatal intensive care unit. Stool samples were collected from 4 RV vaccinated (160 samples) and 23 unvaccinated (766 samples) infants. RV viral RNA loads were measured using real-time reverse transcription polymerase chain reaction (RT-PCR). RV vaccine strain RNA was persistently detected in stool samples collected from the four vaccine recipients and one unvaccinated infant, but not in the stool samples collected from the 22 other unvaccinated infants. The unvaccinated infant who tested positive for the RV vaccine strain was vaccinated prior to enrollment in this study. The quantitative real-time RT-PCR data revealed a peak viral RNA load 1 week after vaccination followed by a gradual decrease. The current study suggests that RV vaccination may be safe in a close contact environment because there was limited transmission from RV vaccinated to unvaccinated infants. J. Med. Virol. 89:79–84, 2017.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalJournal of Medical Virology
Volume89
Issue number1
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Rotavirus Vaccines
Rotavirus
Vaccination
Viral RNA
Viral Load
Reverse Transcription
Vaccines
Safety
Polymerase Chain Reaction
Neonatal Intensive Care Units
Siblings
RNA

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Miura, Hiroki ; Kawamura, Yoshiki ; Sugata, Ken ; Koshiyama, Nozomi ; Yoshikawa, Akiko ; Komoto, Satoshi ; Taniguchi, Koki ; Ihira, Masaru ; Yoshikawa, Tetsushi. / Rotavirus vaccine strain transmission by vaccinated infants in the foster home. In: Journal of Medical Virology. 2017 ; Vol. 89, No. 1. pp. 79-84.
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Rotavirus vaccine strain transmission by vaccinated infants in the foster home. / Miura, Hiroki; Kawamura, Yoshiki; Sugata, Ken; Koshiyama, Nozomi; Yoshikawa, Akiko; Komoto, Satoshi; Taniguchi, Koki; Ihira, Masaru; Yoshikawa, Tetsushi.

In: Journal of Medical Virology, Vol. 89, No. 1, 01.01.2017, p. 79-84.

Research output: Contribution to journalArticle

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