Safety and Clinical Study of Calcium Pantetheine-S-Sulfonate in Patients with Hyperpigmentation

Ritsuko Hayakawa, Kayoko Matsunaga, Chikako Ukei, Kumiko Ohiwa

Research output: Contribution to journalArticlepeer-review

Abstract

Calcium Pantetheine-S-Sulfonate (PaSSOsCa) is one of the pantothenic acid derivatives. We examined PaSSOaCa inhibition capacity of melanin formation in vitro. For the safety evaluation, we tested PaSSOsCa cream to the fifty one patients with skin diseases by closed patch method. And clinical evaluation of PaSSOsCa was performed in the fifty patients with hyperpigmentation by half side method. Results were as follows; 1. We showed PaSSOsCa inhibition capacity of melanin formation in vitro. 2. PaSSOsCa cream was shown to be safety to the human skin. 3. 10% PaSSOsCa cream lightened the skin hyperpigmentation more than placebo cream.

Original languageEnglish
Pages (from-to)162-174
Number of pages13
Journalskin research
Volume26
Issue number1
DOIs
Publication statusPublished - 01-01-1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

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