Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: Comparison with diazepam

Kazushige Mizoguchi, Ryuji Ikeda, Hirotaka Shoji, Yayoi Tanaka, Xue Long Jin, Yoshio Kase, Shuichi Takeda, Wakako Maruyama, Takeshi Tabira

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Anxiety is frequently observed in several neuropsychiatric disorders, and stress is thought to precipitate or exacerbate anxiety. In this study, the anxiolytic action of a herbal medicine, saikokaryukotsuboreito, (SRBT) was examined in normal healthy rats using the elevated plus-maze test. Moreover, the improving effect of SRBT on chronic stress-induced anxiety was also examined. Single administration of SRBT did not have anxiolytic action in normal rats. Repeated administration of SRBT significantly improved chronic stress-induced anxiety. On the other hand, single administration of a typical anxiolytic, diazepam, had anxiolytic action in normal rats but repeated administration did not improve chronic stress-induced anxiety. These results suggest that SRBT does not have anxiolytic activity equivalent to that of diazepam but has potency for improving stress-related anxiety. This finding provides information important for the treatment of anxiety.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalJournal of Natural Medicines
Issue number1
Publication statusPublished - 01-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine


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