Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: Comparison with diazepam

Kazushige Mizoguchi, Ryuji Ikeda, Hirotaka Shoji, Yayoi Tanaka, Xue Long Jin, Yoshio Kase, Shuichi Takeda, Wakako Maruyama, Takeshi Tabira

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Abstract

Anxiety is frequently observed in several neuropsychiatric disorders, and stress is thought to precipitate or exacerbate anxiety. In this study, the anxiolytic action of a herbal medicine, saikokaryukotsuboreito, (SRBT) was examined in normal healthy rats using the elevated plus-maze test. Moreover, the improving effect of SRBT on chronic stress-induced anxiety was also examined. Single administration of SRBT did not have anxiolytic action in normal rats. Repeated administration of SRBT significantly improved chronic stress-induced anxiety. On the other hand, single administration of a typical anxiolytic, diazepam, had anxiolytic action in normal rats but repeated administration did not improve chronic stress-induced anxiety. These results suggest that SRBT does not have anxiolytic activity equivalent to that of diazepam but has potency for improving stress-related anxiety. This finding provides information important for the treatment of anxiety.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalJournal of Natural Medicines
Volume63
Issue number1
DOIs
Publication statusPublished - 01-01-2009

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Complementary and alternative medicine

Cite this

Mizoguchi, K., Ikeda, R., Shoji, H., Tanaka, Y., Jin, X. L., Kase, Y., Takeda, S., Maruyama, W., & Tabira, T. (2009). Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: Comparison with diazepam. Journal of Natural Medicines, 63(1), 69-74. https://doi.org/10.1007/s11418-008-0281-9