TY - JOUR
T1 - Sarcomatous component in pancreatic adenosquamous carcinoma
T2 - A clinicopathological series of 7 cases
AU - Taniwaki, Shinichi
AU - Hisaka, Toru
AU - Sakai, Hisamune
AU - Goto, Yuichi
AU - Nomura, Yoriko
AU - Kawahara, Ryuichi
AU - Ishikawa, Hiroto
AU - Yasunaga, Masafumi
AU - Naito, Yoshiki
AU - Akiba, Jun
AU - Yano, Hirohisa
AU - Tanaka, Hiroyuki
AU - Akagi, Yoshito
AU - Okuda, Koji
N1 - Publisher Copyright:
© 2019 International Institute of Anticancer Research. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Background/Aim: The aim of this study was to examine the clinicopathological features of pancreatic adenosquamous carcinoma (PASC). Patients and Methods: Our study included seven patients who underwent resection of PASC. Results: PASC is characterized by large tumors and strong infiltration into the major blood vessels and other organs, forcing many patients to undergo extended resections. In addition, all patients experienced liver metastasis recurrence following surgery, with a very poor prognosis. Histopathologically, a poorly differentiated sarcomatous component existed in all patients in addition to an adenocarcinoma component and squamous carcinoma component. Although P40 staining for the sarcomatous component was positive along with squamous carcinoma, E-cadherin expression disappeared while vimentin was expressed. It has been suggested that it is highly likely that these sarcomatous components are derived from squamous carcinoma and have an impact on prognosis. Conclusion: The sarcomatous component may be related to the biological malignancy of PASC.
AB - Background/Aim: The aim of this study was to examine the clinicopathological features of pancreatic adenosquamous carcinoma (PASC). Patients and Methods: Our study included seven patients who underwent resection of PASC. Results: PASC is characterized by large tumors and strong infiltration into the major blood vessels and other organs, forcing many patients to undergo extended resections. In addition, all patients experienced liver metastasis recurrence following surgery, with a very poor prognosis. Histopathologically, a poorly differentiated sarcomatous component existed in all patients in addition to an adenocarcinoma component and squamous carcinoma component. Although P40 staining for the sarcomatous component was positive along with squamous carcinoma, E-cadherin expression disappeared while vimentin was expressed. It has been suggested that it is highly likely that these sarcomatous components are derived from squamous carcinoma and have an impact on prognosis. Conclusion: The sarcomatous component may be related to the biological malignancy of PASC.
KW - Clinicopathological study
KW - Pancreatic adenosquamous carcinoma
KW - Sarcomatous components
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U2 - 10.21873/anticanres.13636
DO - 10.21873/anticanres.13636
M3 - Article
C2 - 31366562
AN - SCOPUS:85070709450
SN - 0250-7005
VL - 39
SP - 4575
EP - 4580
JO - Anticancer research
JF - Anticancer research
IS - 8
ER -
