TY - JOUR
T1 - Score of the preoperative absolute number of lymphocytes, monocytes, and neutrophils as a prognostic indicator for patients with gastric cancer
AU - Saito, Hiroaki
AU - Shimizu, Shota
AU - Kono, Yusuke
AU - Murakami, Yuki
AU - Shishido, Yuji
AU - Miyatani, Kozo
AU - Matsunaga, Tomoyuki
AU - Fukumoto, Yoji
AU - Ashida, Keigo
AU - Fujiwara, Yoshiyuki
N1 - Publisher Copyright:
© 2019, Springer Nature Singapore Pte Ltd.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Purpose: The association between the preoperative absolute neutrophil count (NC), lymphocyte count (LC), and monocyte count (MC) in the peripheral blood and the prognosis of gastric cancer (GC) patients has not been investigated widely. Methods: We enrolled 445 patients who underwent surgery for GC between January, 2005 and April, 2013 to analyze the correlations among NC, LC, and MC and their prognoses. Results: Based on cut-off values calculated by ROC analysis, patients were sub grouped as having: NC ≥ 4477 (NCHigh), NC < 4477 (NCLow); and as LC ≥ 1447 (LCHigh), LC < 1447 (LCLow); and as MC ≥ 658.5 (MCHigh), MC < 658.5 (MCLow). Each group was assigned as follows; NCHigh group = 1, NCLow group = 0, LCHigh group = 0, LCLow group = 1, MCHigh group = 1, MCLow group = 0, and the sum of each score was defined as the lymphocyte–monocyte–neutrophil score (LMN score). The overall 5-year survival rates were 89%, 74%, 57.8%, and 53.3% for LMN scores of 0, 1, 2, and 3, respectively (P = 0.0004). Multivariate analysis indicated that the LMN score was an independent prognostic indicator. Conclusions: The combination of preoperative NC, LC, and MC appears to be a useful indicator of GC prognosis.
AB - Purpose: The association between the preoperative absolute neutrophil count (NC), lymphocyte count (LC), and monocyte count (MC) in the peripheral blood and the prognosis of gastric cancer (GC) patients has not been investigated widely. Methods: We enrolled 445 patients who underwent surgery for GC between January, 2005 and April, 2013 to analyze the correlations among NC, LC, and MC and their prognoses. Results: Based on cut-off values calculated by ROC analysis, patients were sub grouped as having: NC ≥ 4477 (NCHigh), NC < 4477 (NCLow); and as LC ≥ 1447 (LCHigh), LC < 1447 (LCLow); and as MC ≥ 658.5 (MCHigh), MC < 658.5 (MCLow). Each group was assigned as follows; NCHigh group = 1, NCLow group = 0, LCHigh group = 0, LCLow group = 1, MCHigh group = 1, MCLow group = 0, and the sum of each score was defined as the lymphocyte–monocyte–neutrophil score (LMN score). The overall 5-year survival rates were 89%, 74%, 57.8%, and 53.3% for LMN scores of 0, 1, 2, and 3, respectively (P = 0.0004). Multivariate analysis indicated that the LMN score was an independent prognostic indicator. Conclusions: The combination of preoperative NC, LC, and MC appears to be a useful indicator of GC prognosis.
KW - Gastric cancer
KW - Lymphocyte
KW - Monocyte
KW - Neutrophil
KW - Prognosis
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U2 - 10.1007/s00595-019-01817-6
DO - 10.1007/s00595-019-01817-6
M3 - Article
C2 - 31062094
AN - SCOPUS:85065318809
SN - 0941-1291
VL - 49
SP - 850
EP - 858
JO - Surgery Today
JF - Surgery Today
IS - 10
ER -
