Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population

Yasunaga Ono, Atsushi Suzuki, Motoko Kotake, Xiaoli Zhang, Keiko Nishiwaki-Yasuda, Yoko Ishiwata, Shigeo Imamura, Mutsuko Nagata, Satoru Takamoto, Mitsuyasu Itoh

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We conducted an observational study in order to assess the prevalence of hypovitaminosis D and its seasonal changes, in the Tokai area (N35.3 E137.0), in 197 normal subjects in Japan. The mean serum 25-hydroxyvitamin D (25-OHD) level measured by direct radioimmunoassay (RIA) was lowest at the end of winter, and highest at the end of summer (15.1 ± 7.1 ng/ml in March; 21.5 ± 5.5 ng/ml in June; 31.6 ± 5.6 ng/ml in September; 23.1 ± 5.3 ng/ml in December; mean ± SD). The prevalence of hypovitaminosis D (<20 ng/ml) was 86.7%, 33.4%, 1.0%, and 26.0% in March, June, September, and December, respectively. Mean plasma intact parathyroid hormone (iPTH) concentration was lowest at the end of summer and highest at the end of winter (28.2 ± 9.3 pg/ml in March; 21.7 ± 7.0 pg/ml in June; 19.8 ± 6.9 pg/ml in September; and 25.7 ± 9.2 pg/ml in December; mean ± SD). Serum 25-OHD was inversely associated with iPTH (coefficient, -0.223; r = 0.251; P < 0.001). Serum 25-OHD levels were higher in men than in women. The serum 25-OHD level was positively associated with age, body weight, and body mass index, but not with body fat content. These results suggest a high prevalence of hypovitaminosis D associated with elevation of iPTH in Japan, in winter, even in a sunny area.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalJournal of Bone and Mineral Metabolism
Volume23
Issue number2
DOIs
Publication statusPublished - 01-03-2005

Fingerprint

Parathyroid Hormone
Serum
Population
Japan
Radioimmunoassay
Observational Studies
Adipose Tissue
Body Mass Index
Body Weight
25-hydroxyvitamin D

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Ono, Yasunaga ; Suzuki, Atsushi ; Kotake, Motoko ; Zhang, Xiaoli ; Nishiwaki-Yasuda, Keiko ; Ishiwata, Yoko ; Imamura, Shigeo ; Nagata, Mutsuko ; Takamoto, Satoru ; Itoh, Mitsuyasu. / Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population. In: Journal of Bone and Mineral Metabolism. 2005 ; Vol. 23, No. 2. pp. 147-151.
@article{926e72c1194f47dbb1c7f956902698be,
title = "Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population",
abstract = "We conducted an observational study in order to assess the prevalence of hypovitaminosis D and its seasonal changes, in the Tokai area (N35.3 E137.0), in 197 normal subjects in Japan. The mean serum 25-hydroxyvitamin D (25-OHD) level measured by direct radioimmunoassay (RIA) was lowest at the end of winter, and highest at the end of summer (15.1 ± 7.1 ng/ml in March; 21.5 ± 5.5 ng/ml in June; 31.6 ± 5.6 ng/ml in September; 23.1 ± 5.3 ng/ml in December; mean ± SD). The prevalence of hypovitaminosis D (<20 ng/ml) was 86.7{\%}, 33.4{\%}, 1.0{\%}, and 26.0{\%} in March, June, September, and December, respectively. Mean plasma intact parathyroid hormone (iPTH) concentration was lowest at the end of summer and highest at the end of winter (28.2 ± 9.3 pg/ml in March; 21.7 ± 7.0 pg/ml in June; 19.8 ± 6.9 pg/ml in September; and 25.7 ± 9.2 pg/ml in December; mean ± SD). Serum 25-OHD was inversely associated with iPTH (coefficient, -0.223; r = 0.251; P < 0.001). Serum 25-OHD levels were higher in men than in women. The serum 25-OHD level was positively associated with age, body weight, and body mass index, but not with body fat content. These results suggest a high prevalence of hypovitaminosis D associated with elevation of iPTH in Japan, in winter, even in a sunny area.",
author = "Yasunaga Ono and Atsushi Suzuki and Motoko Kotake and Xiaoli Zhang and Keiko Nishiwaki-Yasuda and Yoko Ishiwata and Shigeo Imamura and Mutsuko Nagata and Satoru Takamoto and Mitsuyasu Itoh",
year = "2005",
month = "3",
day = "1",
doi = "10.1007/s00774-004-0553-8",
language = "English",
volume = "23",
pages = "147--151",
journal = "Journal of Bone and Mineral Metabolism",
issn = "0914-8779",
publisher = "Springer Japan",
number = "2",

}

Ono, Y, Suzuki, A, Kotake, M, Zhang, X, Nishiwaki-Yasuda, K, Ishiwata, Y, Imamura, S, Nagata, M, Takamoto, S & Itoh, M 2005, 'Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population', Journal of Bone and Mineral Metabolism, vol. 23, no. 2, pp. 147-151. https://doi.org/10.1007/s00774-004-0553-8

Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population. / Ono, Yasunaga; Suzuki, Atsushi; Kotake, Motoko; Zhang, Xiaoli; Nishiwaki-Yasuda, Keiko; Ishiwata, Yoko; Imamura, Shigeo; Nagata, Mutsuko; Takamoto, Satoru; Itoh, Mitsuyasu.

In: Journal of Bone and Mineral Metabolism, Vol. 23, No. 2, 01.03.2005, p. 147-151.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population

AU - Ono, Yasunaga

AU - Suzuki, Atsushi

AU - Kotake, Motoko

AU - Zhang, Xiaoli

AU - Nishiwaki-Yasuda, Keiko

AU - Ishiwata, Yoko

AU - Imamura, Shigeo

AU - Nagata, Mutsuko

AU - Takamoto, Satoru

AU - Itoh, Mitsuyasu

PY - 2005/3/1

Y1 - 2005/3/1

N2 - We conducted an observational study in order to assess the prevalence of hypovitaminosis D and its seasonal changes, in the Tokai area (N35.3 E137.0), in 197 normal subjects in Japan. The mean serum 25-hydroxyvitamin D (25-OHD) level measured by direct radioimmunoassay (RIA) was lowest at the end of winter, and highest at the end of summer (15.1 ± 7.1 ng/ml in March; 21.5 ± 5.5 ng/ml in June; 31.6 ± 5.6 ng/ml in September; 23.1 ± 5.3 ng/ml in December; mean ± SD). The prevalence of hypovitaminosis D (<20 ng/ml) was 86.7%, 33.4%, 1.0%, and 26.0% in March, June, September, and December, respectively. Mean plasma intact parathyroid hormone (iPTH) concentration was lowest at the end of summer and highest at the end of winter (28.2 ± 9.3 pg/ml in March; 21.7 ± 7.0 pg/ml in June; 19.8 ± 6.9 pg/ml in September; and 25.7 ± 9.2 pg/ml in December; mean ± SD). Serum 25-OHD was inversely associated with iPTH (coefficient, -0.223; r = 0.251; P < 0.001). Serum 25-OHD levels were higher in men than in women. The serum 25-OHD level was positively associated with age, body weight, and body mass index, but not with body fat content. These results suggest a high prevalence of hypovitaminosis D associated with elevation of iPTH in Japan, in winter, even in a sunny area.

AB - We conducted an observational study in order to assess the prevalence of hypovitaminosis D and its seasonal changes, in the Tokai area (N35.3 E137.0), in 197 normal subjects in Japan. The mean serum 25-hydroxyvitamin D (25-OHD) level measured by direct radioimmunoassay (RIA) was lowest at the end of winter, and highest at the end of summer (15.1 ± 7.1 ng/ml in March; 21.5 ± 5.5 ng/ml in June; 31.6 ± 5.6 ng/ml in September; 23.1 ± 5.3 ng/ml in December; mean ± SD). The prevalence of hypovitaminosis D (<20 ng/ml) was 86.7%, 33.4%, 1.0%, and 26.0% in March, June, September, and December, respectively. Mean plasma intact parathyroid hormone (iPTH) concentration was lowest at the end of summer and highest at the end of winter (28.2 ± 9.3 pg/ml in March; 21.7 ± 7.0 pg/ml in June; 19.8 ± 6.9 pg/ml in September; and 25.7 ± 9.2 pg/ml in December; mean ± SD). Serum 25-OHD was inversely associated with iPTH (coefficient, -0.223; r = 0.251; P < 0.001). Serum 25-OHD levels were higher in men than in women. The serum 25-OHD level was positively associated with age, body weight, and body mass index, but not with body fat content. These results suggest a high prevalence of hypovitaminosis D associated with elevation of iPTH in Japan, in winter, even in a sunny area.

UR - http://www.scopus.com/inward/record.url?scp=20944437569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20944437569&partnerID=8YFLogxK

U2 - 10.1007/s00774-004-0553-8

DO - 10.1007/s00774-004-0553-8

M3 - Article

C2 - 15750693

AN - SCOPUS:20944437569

VL - 23

SP - 147

EP - 151

JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

SN - 0914-8779

IS - 2

ER -