Seaweed intake and risk of cardiovascular disease: The Japan Public Health Center-based Prospective (JPHC) Study

Utako Murai, Kazumasa Yamagishi, Mizuki Sata, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Junko Ishihara, Manami Inoue, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

Research output: Contribution to journalArticle

Abstract

Background: The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established. Objectives: We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population. Methods: We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40-69 y). Seaweed intake was determined by FFQ at baseline (1990-1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors. Results: During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95% CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women. Conclusions: Seaweed intake was inversely associated with risk of ischemic heart disease.

Original languageEnglish
Pages (from-to)1449-1455
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume110
Issue number6
DOIs
Publication statusPublished - 01-12-2019

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Seaweed
Japan
Cardiovascular Diseases
Public Health
Myocardial Ischemia
Prospective Studies
Stroke
Dietary Fiber
Subarachnoid Hemorrhage
Proportional Hazards Models
Flavonoids
Vitamins
Minerals
Hemorrhage
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Murai, Utako ; Yamagishi, Kazumasa ; Sata, Mizuki ; Kokubo, Yoshihiro ; Saito, Isao ; Yatsuya, Hiroshi ; Ishihara, Junko ; Inoue, Manami ; Sawada, Norie ; Iso, Hiroyasu ; Tsugane, Shoichiro. / Seaweed intake and risk of cardiovascular disease : The Japan Public Health Center-based Prospective (JPHC) Study. In: American Journal of Clinical Nutrition. 2019 ; Vol. 110, No. 6. pp. 1449-1455.
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title = "Seaweed intake and risk of cardiovascular disease: The Japan Public Health Center-based Prospective (JPHC) Study",
abstract = "Background: The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established. Objectives: We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population. Methods: We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40-69 y). Seaweed intake was determined by FFQ at baseline (1990-1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95{\%} CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors. Results: During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95{\%} CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women. Conclusions: Seaweed intake was inversely associated with risk of ischemic heart disease.",
author = "Utako Murai and Kazumasa Yamagishi and Mizuki Sata and Yoshihiro Kokubo and Isao Saito and Hiroshi Yatsuya and Junko Ishihara and Manami Inoue and Norie Sawada and Hiroyasu Iso and Shoichiro Tsugane",
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Murai, U, Yamagishi, K, Sata, M, Kokubo, Y, Saito, I, Yatsuya, H, Ishihara, J, Inoue, M, Sawada, N, Iso, H & Tsugane, S 2019, 'Seaweed intake and risk of cardiovascular disease: The Japan Public Health Center-based Prospective (JPHC) Study', American Journal of Clinical Nutrition, vol. 110, no. 6, pp. 1449-1455. https://doi.org/10.1093/ajcn/nqz231

Seaweed intake and risk of cardiovascular disease : The Japan Public Health Center-based Prospective (JPHC) Study. / Murai, Utako; Yamagishi, Kazumasa; Sata, Mizuki; Kokubo, Yoshihiro; Saito, Isao; Yatsuya, Hiroshi; Ishihara, Junko; Inoue, Manami; Sawada, Norie; Iso, Hiroyasu; Tsugane, Shoichiro.

In: American Journal of Clinical Nutrition, Vol. 110, No. 6, 01.12.2019, p. 1449-1455.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Seaweed intake and risk of cardiovascular disease

T2 - The Japan Public Health Center-based Prospective (JPHC) Study

AU - Murai, Utako

AU - Yamagishi, Kazumasa

AU - Sata, Mizuki

AU - Kokubo, Yoshihiro

AU - Saito, Isao

AU - Yatsuya, Hiroshi

AU - Ishihara, Junko

AU - Inoue, Manami

AU - Sawada, Norie

AU - Iso, Hiroyasu

AU - Tsugane, Shoichiro

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Background: The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established. Objectives: We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population. Methods: We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40-69 y). Seaweed intake was determined by FFQ at baseline (1990-1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors. Results: During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95% CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women. Conclusions: Seaweed intake was inversely associated with risk of ischemic heart disease.

AB - Background: The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established. Objectives: We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population. Methods: We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40-69 y). Seaweed intake was determined by FFQ at baseline (1990-1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors. Results: During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95% CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women. Conclusions: Seaweed intake was inversely associated with risk of ischemic heart disease.

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JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

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