Second allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia

K. Kudo, H. Muramatsu, N. Yoshida, R. Kobayashi, H. Yabe, K. Tabuchi, K. Kato, K. Koh, Y. Takahashi, Y. Hashii, Y. Kawano, M. Inoue, Y. Cho, H. Sakamaki, K. Kawa, K. Kato, R. Suzuki, S. Kojima

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Abstract

The outcome of 55 children with severe aplastic anemia (SAA) who received a second hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed using the registration data of the Japanese Society for Hematopoietic Cell Transplantation. The 5-year overall survival (OS) and failure-free survival (FFS) after the second transplantation were 82.9% (95% confidence interval (CI), 69.7-90.8)) and 81.2% (95% CI, 67.8-89.4), respectively. FFS was significantly better when the interval between the first and second transplantation was >60 days (88.9%; 95% CI, 73.0-95.7) than when it was ≤60 days (61.4%; 95% CI, 33.3-80.5; P=0.026). All 12 patients who were conditioned with regimens containing fludarabine and melphalan were alive with hematopoietic recovery. These findings justify the recommendation of a second HSCT for children with SAA who have experienced graft failure after first HSCT.

Original languageEnglish
Pages (from-to)1312-1315
Number of pages4
JournalBone Marrow Transplantation
Volume50
Issue number10
DOIs
Publication statusPublished - 01-10-2015

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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    Kudo, K., Muramatsu, H., Yoshida, N., Kobayashi, R., Yabe, H., Tabuchi, K., Kato, K., Koh, K., Takahashi, Y., Hashii, Y., Kawano, Y., Inoue, M., Cho, Y., Sakamaki, H., Kawa, K., Kato, K., Suzuki, R., & Kojima, S. (2015). Second allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia. Bone Marrow Transplantation, 50(10), 1312-1315. https://doi.org/10.1038/bmt.2015.153