Secondary Glioblastoma Remarkably Reduced by Steroid Administration After Anaplastic Transformation from Gliomatosis Cerebri: —Case Report—

Yuichi Hirose, Takuro Hayashi, Masachika Sagoh, Hideki Murakami

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A 45-year-old female presented with gliomatosis cerebri manifesting as hemiballismus-like involuntary movement in the arm, motor weakness in the leg, and hypesthesia in her left side. Computed tomography showed only diffuse swelling of the right cerebral hemisphere. but T2-weighted magnetic resonance imaging revealed a diffuse lesion spreading from the right thalamus to the temporal. parietal, and occipital lobes on the same side. No abnormal enhancement was recognized. Cerebral angiography showed no specific finding. A right occipital lobectomy was performed to confirm the diagnosis of gliomatosis cerebri. Anaplastic transformation was recognized 5 months later. The disease did not resolve with radiation or interferon administration, but steroid therapy achieved remarkably effective tumor regression. The patient died due to pneumonia. Autopsy showed the features of diffuse glioblastoma. Steroid therapy may be an effective treatment for gliomatosis cerebri before the terminal stage.

Original languageEnglish
Pages (from-to)865-870
Number of pages6
JournalNeurologia medico-chirurgica
Volume38
Issue number12
DOIs
Publication statusPublished - 01-01-1998

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Neuroepithelial Neoplasms
Glioblastoma
Steroids
Dyskinesias
Occipital Lobe
Cerebral Angiography
Parietal Lobe
Hypesthesia
Cerebrum
Thalamus
Interferons
Autopsy
Leg
Pneumonia
Arm
Therapeutics
Tomography
Magnetic Resonance Imaging
Radiation
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

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abstract = "A 45-year-old female presented with gliomatosis cerebri manifesting as hemiballismus-like involuntary movement in the arm, motor weakness in the leg, and hypesthesia in her left side. Computed tomography showed only diffuse swelling of the right cerebral hemisphere. but T2-weighted magnetic resonance imaging revealed a diffuse lesion spreading from the right thalamus to the temporal. parietal, and occipital lobes on the same side. No abnormal enhancement was recognized. Cerebral angiography showed no specific finding. A right occipital lobectomy was performed to confirm the diagnosis of gliomatosis cerebri. Anaplastic transformation was recognized 5 months later. The disease did not resolve with radiation or interferon administration, but steroid therapy achieved remarkably effective tumor regression. The patient died due to pneumonia. Autopsy showed the features of diffuse glioblastoma. Steroid therapy may be an effective treatment for gliomatosis cerebri before the terminal stage.",
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Secondary Glioblastoma Remarkably Reduced by Steroid Administration After Anaplastic Transformation from Gliomatosis Cerebri : —Case Report—. / Hirose, Yuichi; Hayashi, Takuro; Sagoh, Masachika; Murakami, Hideki.

In: Neurologia medico-chirurgica, Vol. 38, No. 12, 01.01.1998, p. 865-870.

Research output: Contribution to journalArticle

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