Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population: The Hisayama study

Keiichi Tanaka, Yutaka Kiyohara, Michiaki Kubo, Takayuki Matsumoto, Yumihiro Tanizaki, Ken Okubo, Toshiharu Ninomiya, Yoshinori Oishi, Kentaro Shikata, Mitsuo Iida

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Abstract

To examine secular trends in the incidence and mortality of gastric cancer in a Japanese community, Hisayama, we established three study-cohorts of Hisayama residents aged ≥40 years in 1961 (1637 subjects), 1974 (2054), and 1988 (2602). Each cohort was followed up for ten years. The age-standardized mortality from gastric cancer significantly decreased from 2.4 per 1000 person-years in the first cohort to 0.8 in the third cohort for men, and from 1.0 to 0.2, respectively, for women (p < 0.01 for trend in both sexes). The five-year survival rate after gastric cancer significantly improved from the first (32.6%) to the third cohort (73.0%, p < 0.01) for men and from 43.2% to 72.3% (p < 0.05), respectively, for women. The age-standardized incidence of cancer in men was not different among the cohorts (4.3 per 1000 person-years in the first, 5.0 in the second, and 4.9 in the third cohort), while it decreased significantly in women (2.0, 1.8, and 1.2, respectively, p < 0.01 for trend). In conclusion, our findings suggest that in a Japanese population, the mortality from gastric cancer declined during the past 40 years, due mainly to the improvement of survival in both sexes and a decrease in the incidence for women.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalCancer Causes and Control
Volume16
Issue number5
DOIs
Publication statusPublished - 01-06-2005

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Stomach Neoplasms
Survival Rate
Mortality
Incidence
Population
Cohort Studies
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tanaka, Keiichi ; Kiyohara, Yutaka ; Kubo, Michiaki ; Matsumoto, Takayuki ; Tanizaki, Yumihiro ; Okubo, Ken ; Ninomiya, Toshiharu ; Oishi, Yoshinori ; Shikata, Kentaro ; Iida, Mitsuo. / Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population : The Hisayama study. In: Cancer Causes and Control. 2005 ; Vol. 16, No. 5. pp. 573-578.
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abstract = "To examine secular trends in the incidence and mortality of gastric cancer in a Japanese community, Hisayama, we established three study-cohorts of Hisayama residents aged ≥40 years in 1961 (1637 subjects), 1974 (2054), and 1988 (2602). Each cohort was followed up for ten years. The age-standardized mortality from gastric cancer significantly decreased from 2.4 per 1000 person-years in the first cohort to 0.8 in the third cohort for men, and from 1.0 to 0.2, respectively, for women (p < 0.01 for trend in both sexes). The five-year survival rate after gastric cancer significantly improved from the first (32.6{\%}) to the third cohort (73.0{\%}, p < 0.01) for men and from 43.2{\%} to 72.3{\%} (p < 0.05), respectively, for women. The age-standardized incidence of cancer in men was not different among the cohorts (4.3 per 1000 person-years in the first, 5.0 in the second, and 4.9 in the third cohort), while it decreased significantly in women (2.0, 1.8, and 1.2, respectively, p < 0.01 for trend). In conclusion, our findings suggest that in a Japanese population, the mortality from gastric cancer declined during the past 40 years, due mainly to the improvement of survival in both sexes and a decrease in the incidence for women.",
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Tanaka, K, Kiyohara, Y, Kubo, M, Matsumoto, T, Tanizaki, Y, Okubo, K, Ninomiya, T, Oishi, Y, Shikata, K & Iida, M 2005, 'Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population: The Hisayama study', Cancer Causes and Control, vol. 16, no. 5, pp. 573-578. https://doi.org/10.1007/s10552-004-7839-y

Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population : The Hisayama study. / Tanaka, Keiichi; Kiyohara, Yutaka; Kubo, Michiaki; Matsumoto, Takayuki; Tanizaki, Yumihiro; Okubo, Ken; Ninomiya, Toshiharu; Oishi, Yoshinori; Shikata, Kentaro; Iida, Mitsuo.

In: Cancer Causes and Control, Vol. 16, No. 5, 01.06.2005, p. 573-578.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population

T2 - The Hisayama study

AU - Tanaka, Keiichi

AU - Kiyohara, Yutaka

AU - Kubo, Michiaki

AU - Matsumoto, Takayuki

AU - Tanizaki, Yumihiro

AU - Okubo, Ken

AU - Ninomiya, Toshiharu

AU - Oishi, Yoshinori

AU - Shikata, Kentaro

AU - Iida, Mitsuo

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N2 - To examine secular trends in the incidence and mortality of gastric cancer in a Japanese community, Hisayama, we established three study-cohorts of Hisayama residents aged ≥40 years in 1961 (1637 subjects), 1974 (2054), and 1988 (2602). Each cohort was followed up for ten years. The age-standardized mortality from gastric cancer significantly decreased from 2.4 per 1000 person-years in the first cohort to 0.8 in the third cohort for men, and from 1.0 to 0.2, respectively, for women (p < 0.01 for trend in both sexes). The five-year survival rate after gastric cancer significantly improved from the first (32.6%) to the third cohort (73.0%, p < 0.01) for men and from 43.2% to 72.3% (p < 0.05), respectively, for women. The age-standardized incidence of cancer in men was not different among the cohorts (4.3 per 1000 person-years in the first, 5.0 in the second, and 4.9 in the third cohort), while it decreased significantly in women (2.0, 1.8, and 1.2, respectively, p < 0.01 for trend). In conclusion, our findings suggest that in a Japanese population, the mortality from gastric cancer declined during the past 40 years, due mainly to the improvement of survival in both sexes and a decrease in the incidence for women.

AB - To examine secular trends in the incidence and mortality of gastric cancer in a Japanese community, Hisayama, we established three study-cohorts of Hisayama residents aged ≥40 years in 1961 (1637 subjects), 1974 (2054), and 1988 (2602). Each cohort was followed up for ten years. The age-standardized mortality from gastric cancer significantly decreased from 2.4 per 1000 person-years in the first cohort to 0.8 in the third cohort for men, and from 1.0 to 0.2, respectively, for women (p < 0.01 for trend in both sexes). The five-year survival rate after gastric cancer significantly improved from the first (32.6%) to the third cohort (73.0%, p < 0.01) for men and from 43.2% to 72.3% (p < 0.05), respectively, for women. The age-standardized incidence of cancer in men was not different among the cohorts (4.3 per 1000 person-years in the first, 5.0 in the second, and 4.9 in the third cohort), while it decreased significantly in women (2.0, 1.8, and 1.2, respectively, p < 0.01 for trend). In conclusion, our findings suggest that in a Japanese population, the mortality from gastric cancer declined during the past 40 years, due mainly to the improvement of survival in both sexes and a decrease in the incidence for women.

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