Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population: The Hisayama study

Keiichi Tanaka, Yutaka Kiyohara, Michiaki Kubo, Takayuki Matsumoto, Yumihiro Tanizaki, Ken Okubo, Toshiharu Ninomiya, Yoshinori Oishi, Kentaro Shikata, Mitsuo Iida

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Abstract

To examine secular trends in the incidence and mortality of gastric cancer in a Japanese community, Hisayama, we established three study-cohorts of Hisayama residents aged ≥40 years in 1961 (1637 subjects), 1974 (2054), and 1988 (2602). Each cohort was followed up for ten years. The age-standardized mortality from gastric cancer significantly decreased from 2.4 per 1000 person-years in the first cohort to 0.8 in the third cohort for men, and from 1.0 to 0.2, respectively, for women (p < 0.01 for trend in both sexes). The five-year survival rate after gastric cancer significantly improved from the first (32.6%) to the third cohort (73.0%, p < 0.01) for men and from 43.2% to 72.3% (p < 0.05), respectively, for women. The age-standardized incidence of cancer in men was not different among the cohorts (4.3 per 1000 person-years in the first, 5.0 in the second, and 4.9 in the third cohort), while it decreased significantly in women (2.0, 1.8, and 1.2, respectively, p < 0.01 for trend). In conclusion, our findings suggest that in a Japanese population, the mortality from gastric cancer declined during the past 40 years, due mainly to the improvement of survival in both sexes and a decrease in the incidence for women.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalCancer Causes and Control
Volume16
Issue number5
DOIs
Publication statusPublished - 01-06-2005

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Tanaka, K., Kiyohara, Y., Kubo, M., Matsumoto, T., Tanizaki, Y., Okubo, K., Ninomiya, T., Oishi, Y., Shikata, K., & Iida, M. (2005). Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population: The Hisayama study. Cancer Causes and Control, 16(5), 573-578. https://doi.org/10.1007/s10552-004-7839-y