TY - JOUR
T1 - Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population
T2 - The Hisayama study
AU - Tanaka, Keiichi
AU - Kiyohara, Yutaka
AU - Kubo, Michiaki
AU - Matsumoto, Takayuki
AU - Tanizaki, Yumihiro
AU - Okubo, Ken
AU - Ninomiya, Toshiharu
AU - Oishi, Yoshinori
AU - Shikata, Kentaro
AU - Iida, Mitsuo
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid for Scientific Research (C) (No. 13670370), a Special Coordination Fund for Promoting Science, and a Fund for Technology and Innovative Development Project in Life Sciences from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors thank the residents of Hisayama Town for their participation in the survey and the staff of the Division of Health and Welfare of Hisayama for their cooperation in this study.
PY - 2005/6
Y1 - 2005/6
N2 - To examine secular trends in the incidence and mortality of gastric cancer in a Japanese community, Hisayama, we established three study-cohorts of Hisayama residents aged ≥40 years in 1961 (1637 subjects), 1974 (2054), and 1988 (2602). Each cohort was followed up for ten years. The age-standardized mortality from gastric cancer significantly decreased from 2.4 per 1000 person-years in the first cohort to 0.8 in the third cohort for men, and from 1.0 to 0.2, respectively, for women (p < 0.01 for trend in both sexes). The five-year survival rate after gastric cancer significantly improved from the first (32.6%) to the third cohort (73.0%, p < 0.01) for men and from 43.2% to 72.3% (p < 0.05), respectively, for women. The age-standardized incidence of cancer in men was not different among the cohorts (4.3 per 1000 person-years in the first, 5.0 in the second, and 4.9 in the third cohort), while it decreased significantly in women (2.0, 1.8, and 1.2, respectively, p < 0.01 for trend). In conclusion, our findings suggest that in a Japanese population, the mortality from gastric cancer declined during the past 40 years, due mainly to the improvement of survival in both sexes and a decrease in the incidence for women.
AB - To examine secular trends in the incidence and mortality of gastric cancer in a Japanese community, Hisayama, we established three study-cohorts of Hisayama residents aged ≥40 years in 1961 (1637 subjects), 1974 (2054), and 1988 (2602). Each cohort was followed up for ten years. The age-standardized mortality from gastric cancer significantly decreased from 2.4 per 1000 person-years in the first cohort to 0.8 in the third cohort for men, and from 1.0 to 0.2, respectively, for women (p < 0.01 for trend in both sexes). The five-year survival rate after gastric cancer significantly improved from the first (32.6%) to the third cohort (73.0%, p < 0.01) for men and from 43.2% to 72.3% (p < 0.05), respectively, for women. The age-standardized incidence of cancer in men was not different among the cohorts (4.3 per 1000 person-years in the first, 5.0 in the second, and 4.9 in the third cohort), while it decreased significantly in women (2.0, 1.8, and 1.2, respectively, p < 0.01 for trend). In conclusion, our findings suggest that in a Japanese population, the mortality from gastric cancer declined during the past 40 years, due mainly to the improvement of survival in both sexes and a decrease in the incidence for women.
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U2 - 10.1007/s10552-004-7839-y
DO - 10.1007/s10552-004-7839-y
M3 - Article
C2 - 15986112
AN - SCOPUS:21644435526
SN - 0957-5243
VL - 16
SP - 573
EP - 578
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 5
ER -
