TY - JOUR
T1 - Segmentation of liver and spleen based on computational anatomy models
AU - Dong, Chunhua
AU - Chen, Yen Wei
AU - Foruzan, Amir Hossein
AU - Lin, Lanfen
AU - Han, Xian Hua
AU - Tateyama, Tomoko
AU - Wu, Xing
AU - Xu, Gang
AU - Jiang, Huiyan
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Accurate segmentation of abdominal organs is a key step in developing a computer-aided diagnosis (CAD) system. Probabilistic atlas based on human anatomical structure, used as a priori information in a Bayes framework, has been widely used for organ segmentation. How to register the probabilistic atlas to the patient volume is the main challenge. Additionally, there is the disadvantage that the conventional probabilistic atlas may cause a bias toward the specific patient study because of the single reference. Taking these into consideration, a template matching framework based on an iterative probabilistic atlas for liver and spleen segmentation is presented in this paper. First, a bounding box based on human anatomical localization, which refers to the statistical geometric location of the organ, is detected for the candidate organ. Then, the probabilistic atlas is used as a template to find the organ in this bounding box by using template matching technology. We applied our method to 60 datasets including normal and pathological cases. For the liver, the Dice/Tanimoto volume overlaps were 0.930/0.870, the root-mean-squared error (RMSE) was 2.906 mm. For the spleen, quantification led to 0.922 Dice/0.857 Tanimoto overlaps, 1.992 mm RMSE. The algorithm is robust in segmenting normal and abnormal spleens and livers, such as the presence of tumors and large morphological changes. Comparing our method with conventional and recently developed atlas-based methods, our results show an improvement in the segmentation accuracy for multi-organs (p< 0.00001).
AB - Accurate segmentation of abdominal organs is a key step in developing a computer-aided diagnosis (CAD) system. Probabilistic atlas based on human anatomical structure, used as a priori information in a Bayes framework, has been widely used for organ segmentation. How to register the probabilistic atlas to the patient volume is the main challenge. Additionally, there is the disadvantage that the conventional probabilistic atlas may cause a bias toward the specific patient study because of the single reference. Taking these into consideration, a template matching framework based on an iterative probabilistic atlas for liver and spleen segmentation is presented in this paper. First, a bounding box based on human anatomical localization, which refers to the statistical geometric location of the organ, is detected for the candidate organ. Then, the probabilistic atlas is used as a template to find the organ in this bounding box by using template matching technology. We applied our method to 60 datasets including normal and pathological cases. For the liver, the Dice/Tanimoto volume overlaps were 0.930/0.870, the root-mean-squared error (RMSE) was 2.906 mm. For the spleen, quantification led to 0.922 Dice/0.857 Tanimoto overlaps, 1.992 mm RMSE. The algorithm is robust in segmenting normal and abnormal spleens and livers, such as the presence of tumors and large morphological changes. Comparing our method with conventional and recently developed atlas-based methods, our results show an improvement in the segmentation accuracy for multi-organs (p< 0.00001).
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U2 - 10.1016/j.compbiomed.2015.10.007
DO - 10.1016/j.compbiomed.2015.10.007
M3 - Article
C2 - 26551453
AN - SCOPUS:84946407740
SN - 0010-4825
VL - 67
SP - 146
EP - 160
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
ER -