TY - JOUR
T1 - Selection of cases and controls for the nested case-control study within the JACC Study
T2 - The First-wave
AU - Tamakoshi, Akiko
AU - Suzuki, Koji
AU - Ito, Yoshinori
AU - Watanabe, Yoshiyuki
AU - Inaba, Yutaka
AU - Tajima, Kazuo
AU - Nakachi, Kei
AU - Ohno, Yohiyuki
AU - Mori, Mitsuru
AU - Sakauchi, Fumio
AU - Motohashi, Yutaka
AU - Tsuji, Ichiro
AU - Nakamura, Yosikazu
AU - Iso, Hiroyasu
AU - Mikami, Haruo
AU - Kurosawa, Michiko
AU - Hoshiyama, Yoshiharu
AU - Tanabe, Naohito
AU - Tamakoshi, Koji
AU - Wakai, Kenji
AU - Tokudome, Shinkan
AU - Hashimoto, Shuji
AU - Kikuchi, Shogo
AU - Wada, Yasuhiko
AU - Kawamura, Takashi
AU - Watanabe, Yoshiyuki
AU - Ozasa, Kotaro
AU - Miki, Tsuneharu
AU - Date, Chigusa
AU - Sakata, Kiyomi
AU - Kurozawa, Yoichi
AU - Yoshimura, Takesumi
AU - Fujino, Yoshihisa
AU - Shibata, Akira
AU - Okamoto, Naoyuki
AU - Shio, Hideo
PY - 2009/12
Y1 - 2009/12
N2 - In this paper, we describe the methodology of the case and control selection for the first-wave nested casecontrol study within the JACC Study. Among the subjects participating in the cohort, serum samples of 42,249 subjects (including 39,242 subjects aged between 40 and 79 at the baseline) were suitable for biochemical analysis. We here selected those who had died by 1997 or who were diagnosed with cancer with sera until 1994 as cases. For each case, 3 to 4 controls with sera were randomly selected, with matching for gender, age (as near as possible) and residential area. As a result, 3,144 cases and 10,661 controls (2,867 cases and 10,351 controls were 40 to 79 years old at the baseline) were selected to measure serum IGF-I, IGF-II, IGFBP-3, TGF-β1 and sFas values and total SOD activity. Cases were older and more likely to be men than the JACC Study subjects. Moreover, they were much older than controls because of the age-dependence of susceptibility to death, especially among men. There were more smokers among cases compared with controls, though drinkers at the baseline were fewer. Among deceased cases, cancer was the leading cause of death, followed by cardiovascular diseases. Lung cancer was most frequent among deceased cancer cases and the next most common site was the stomach. The leading cause of cancer incidence was stomach cancer followed by lung cancer. Simple comparison of means and distribution of IGF-I, IGF-II, IGFBP-3, TGF-β1, sFas and total SOD activity between cases and controls revealed total SOD activity and sFas levels of cases to be higher than controls, while for the other components the opposite was found.
AB - In this paper, we describe the methodology of the case and control selection for the first-wave nested casecontrol study within the JACC Study. Among the subjects participating in the cohort, serum samples of 42,249 subjects (including 39,242 subjects aged between 40 and 79 at the baseline) were suitable for biochemical analysis. We here selected those who had died by 1997 or who were diagnosed with cancer with sera until 1994 as cases. For each case, 3 to 4 controls with sera were randomly selected, with matching for gender, age (as near as possible) and residential area. As a result, 3,144 cases and 10,661 controls (2,867 cases and 10,351 controls were 40 to 79 years old at the baseline) were selected to measure serum IGF-I, IGF-II, IGFBP-3, TGF-β1 and sFas values and total SOD activity. Cases were older and more likely to be men than the JACC Study subjects. Moreover, they were much older than controls because of the age-dependence of susceptibility to death, especially among men. There were more smokers among cases compared with controls, though drinkers at the baseline were fewer. Among deceased cases, cancer was the leading cause of death, followed by cardiovascular diseases. Lung cancer was most frequent among deceased cancer cases and the next most common site was the stomach. The leading cause of cancer incidence was stomach cancer followed by lung cancer. Simple comparison of means and distribution of IGF-I, IGF-II, IGFBP-3, TGF-β1, sFas and total SOD activity between cases and controls revealed total SOD activity and sFas levels of cases to be higher than controls, while for the other components the opposite was found.
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M3 - Article
C2 - 20553075
AN - SCOPUS:84865713108
SN - 1513-7368
VL - 10
SP - 1
EP - 7
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - SUPPL.1
ER -
