Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5

Masashi Kondo, Shuhei Matsuoka, Kosaku Uchida, Hirotaka Osada, Masaaki Nagatake, Kenzo Takagi, J. Wade Harper, Toshitada Takahashi, Stephen J. Elledge, Takashi Takahashi

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Genomic imprinting at 11p15 is suggested to play a role in certain pediatric tumors such as Wilms' tumor, based on the findings of selective maternal loss of this chromosomal region. Although the allele loss at 11p15 is also frequent in a number of cancers of adults including lung, breast, and bladder cancers, possible involvement of genomic imprinting in these tumors has not been investigated extensively. p57KIP2, a newly described member of the p21 cyclin-dependent kinase (CDK) inhibitor family which is thought to negatively regulate the cell cylce at the G1 checkpoint, has been mapped to 11p15. In the present study, we searched for somatic p57KIP2 mutations in lung cancer, but failed to find such alterations. Interestingly, however, we found that the p57KIP2 gene is imprinted with maternal expression and that the maternal alleles had been selectively lost in 11 of 13 (85%) lung cancer cases carrying 11p15 deletions, this being a significant bias (P=0.01). These data provide the first evidence that genomic imprinting may play a role in the oncogenesis of not only rare pediatric tumors but also this common cancer of adults, suggesting that the imprinted p57KIP2 CDK inhibitor gene is a potential target for maternally biased 11p15 deletions.

Original languageEnglish
Pages (from-to)1365-1368
Number of pages4
JournalOncogene
Volume12
Issue number6
Publication statusPublished - 01-12-1996

Fingerprint

Lung Neoplasms
Genomic Imprinting
Alleles
Mothers
Genes
Neoplasms
Cyclin-Dependent Kinase Inhibitor p21
Pediatrics
Wilms Tumor
Cyclin-Dependent Kinases
Urinary Bladder Neoplasms
Carcinogenesis
Breast Neoplasms
Mutation

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Kondo, M., Matsuoka, S., Uchida, K., Osada, H., Nagatake, M., Takagi, K., ... Takahashi, T. (1996). Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. Oncogene, 12(6), 1365-1368.
Kondo, Masashi ; Matsuoka, Shuhei ; Uchida, Kosaku ; Osada, Hirotaka ; Nagatake, Masaaki ; Takagi, Kenzo ; Harper, J. Wade ; Takahashi, Toshitada ; Elledge, Stephen J. ; Takahashi, Takashi. / Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. In: Oncogene. 1996 ; Vol. 12, No. 6. pp. 1365-1368.
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abstract = "Genomic imprinting at 11p15 is suggested to play a role in certain pediatric tumors such as Wilms' tumor, based on the findings of selective maternal loss of this chromosomal region. Although the allele loss at 11p15 is also frequent in a number of cancers of adults including lung, breast, and bladder cancers, possible involvement of genomic imprinting in these tumors has not been investigated extensively. p57KIP2, a newly described member of the p21 cyclin-dependent kinase (CDK) inhibitor family which is thought to negatively regulate the cell cylce at the G1 checkpoint, has been mapped to 11p15. In the present study, we searched for somatic p57KIP2 mutations in lung cancer, but failed to find such alterations. Interestingly, however, we found that the p57KIP2 gene is imprinted with maternal expression and that the maternal alleles had been selectively lost in 11 of 13 (85{\%}) lung cancer cases carrying 11p15 deletions, this being a significant bias (P=0.01). These data provide the first evidence that genomic imprinting may play a role in the oncogenesis of not only rare pediatric tumors but also this common cancer of adults, suggesting that the imprinted p57KIP2 CDK inhibitor gene is a potential target for maternally biased 11p15 deletions.",
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Kondo, M, Matsuoka, S, Uchida, K, Osada, H, Nagatake, M, Takagi, K, Harper, JW, Takahashi, T, Elledge, SJ & Takahashi, T 1996, 'Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5', Oncogene, vol. 12, no. 6, pp. 1365-1368.

Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. / Kondo, Masashi; Matsuoka, Shuhei; Uchida, Kosaku; Osada, Hirotaka; Nagatake, Masaaki; Takagi, Kenzo; Harper, J. Wade; Takahashi, Toshitada; Elledge, Stephen J.; Takahashi, Takashi.

In: Oncogene, Vol. 12, No. 6, 01.12.1996, p. 1365-1368.

Research output: Contribution to journalArticle

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AU - Osada, Hirotaka

AU - Nagatake, Masaaki

AU - Takagi, Kenzo

AU - Harper, J. Wade

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AU - Elledge, Stephen J.

AU - Takahashi, Takashi

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Kondo M, Matsuoka S, Uchida K, Osada H, Nagatake M, Takagi K et al. Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. Oncogene. 1996 Dec 1;12(6):1365-1368.