Self-reported eczema in relation with mortality from cardiovascular disease in Japanese: The Japan collaborative cohort study

Yoko Nishida, Yasuhiko Kubota, Hiroyasu Iso, Akiko Tamakoshi, Akiko Tamakoshi, Mitsuru Mori, Yoshihiro Kaneko, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Kazumasa Yamagishi, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito Tanabe, Koji Tamakoshi, Kenji Wakai, Masahiko Ando, Koji Suzuki, Shuji HashimotoHiroshi Yatsuya, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Kazuya Mikami, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Yoshihisa Fujino, Akira Shibata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Results: During the 6,389,818 person-years of follow-up, there were 1,174 deaths from coronary heart disease (CHD), 979 from heart failure, 366 from cardiac arrhythmia, 2,454 from total stroke, 1,357 from ischemic stroke, 1,013 from hemorrhagic stroke, and 201 from aortic aneurysm or dissection. The multivariable-adjusted model showed that individuals who “sometimes” or “often” had eczema had 0.82 (95%confidence interval (CI): 0.69–0.97) or 1.26 (95%CI: 1.01–1.56) times the risk of mortality from CHD, respectively, compared to those who “seldom” did. Individuals who “often” had 1.30 (95%CI: 1.05–1.61) times the risk of mortality from CHD, compared to those who “seldom or sometimes” did. There was no association of eczema with mortality from other CVD, or no interaction between eczema and sex or age, in relation to any CVD mortality risk. Conclusions: Self-reported frequent eczema was associated with increased risk of mortality from CHD, but not other major CVD, in a Japanese general population. Since steroid usage was not considered, future studies should include it as a potential confounding factor.

Original languageEnglish
Pages (from-to)775-782
Number of pages8
JournalJournal of atherosclerosis and thrombosis
Volume26
Issue number9
DOIs
Publication statusPublished - 01-01-2019

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Eczema
Japan
Cohort Studies
Cardiovascular Diseases
Mortality
Coronary Disease
Stroke
Confidence Intervals
Aortic Aneurysm
Dissection
Life Style
Cardiac Arrhythmias
Heart Failure
Steroids
Inflammation
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Nishida, Yoko ; Kubota, Yasuhiko ; Iso, Hiroyasu ; Tamakoshi, Akiko ; Tamakoshi, Akiko ; Mori, Mitsuru ; Kaneko, Yoshihiro ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Yamagishi, Kazumasa ; Mikami, Haruo ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Tamakoshi, Koji ; Wakai, Kenji ; Ando, Masahiko ; Suzuki, Koji ; Hashimoto, Shuji ; Yatsuya, Hiroshi ; Kikuchi, Shogo ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Mikami, Kazuya ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Fujino, Yoshihisa ; Shibata, Akira. / Self-reported eczema in relation with mortality from cardiovascular disease in Japanese : The Japan collaborative cohort study. In: Journal of atherosclerosis and thrombosis. 2019 ; Vol. 26, No. 9. pp. 775-782.
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abstract = "Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Results: During the 6,389,818 person-years of follow-up, there were 1,174 deaths from coronary heart disease (CHD), 979 from heart failure, 366 from cardiac arrhythmia, 2,454 from total stroke, 1,357 from ischemic stroke, 1,013 from hemorrhagic stroke, and 201 from aortic aneurysm or dissection. The multivariable-adjusted model showed that individuals who “sometimes” or “often” had eczema had 0.82 (95{\%}confidence interval (CI): 0.69–0.97) or 1.26 (95{\%}CI: 1.01–1.56) times the risk of mortality from CHD, respectively, compared to those who “seldom” did. Individuals who “often” had 1.30 (95{\%}CI: 1.05–1.61) times the risk of mortality from CHD, compared to those who “seldom or sometimes” did. There was no association of eczema with mortality from other CVD, or no interaction between eczema and sex or age, in relation to any CVD mortality risk. Conclusions: Self-reported frequent eczema was associated with increased risk of mortality from CHD, but not other major CVD, in a Japanese general population. Since steroid usage was not considered, future studies should include it as a potential confounding factor.",
author = "Yoko Nishida and Yasuhiko Kubota and Hiroyasu Iso and Akiko Tamakoshi and Akiko Tamakoshi and Mitsuru Mori and Yoshihiro Kaneko and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Kazumasa Yamagishi and Haruo Mikami and Michiko Kurosawa and Yoshiharu Hoshiyama and Naohito Tanabe and Koji Tamakoshi and Kenji Wakai and Masahiko Ando and Koji Suzuki and Shuji Hashimoto and Hiroshi Yatsuya and Shogo Kikuchi and Yasuhiko Wada and Takashi Kawamura and Yoshiyuki Watanabe and Kotaro Ozasa and Kazuya Mikami and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Yoshihisa Fujino and Akira Shibata",
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Nishida, Y, Kubota, Y, Iso, H, Tamakoshi, A, Tamakoshi, A, Mori, M, Kaneko, Y, Tsuji, I, Nakamura, Y, Iso, H, Yamagishi, K, Mikami, H, Kurosawa, M, Hoshiyama, Y, Tanabe, N, Tamakoshi, K, Wakai, K, Ando, M, Suzuki, K, Hashimoto, S, Yatsuya, H, Kikuchi, S, Wada, Y, Kawamura, T, Watanabe, Y, Ozasa, K, Mikami, K, Date, C, Sakata, K, Kurozawa, Y, Fujino, Y & Shibata, A 2019, 'Self-reported eczema in relation with mortality from cardiovascular disease in Japanese: The Japan collaborative cohort study', Journal of atherosclerosis and thrombosis, vol. 26, no. 9, pp. 775-782. https://doi.org/10.5551/jat.46383

Self-reported eczema in relation with mortality from cardiovascular disease in Japanese : The Japan collaborative cohort study. / Nishida, Yoko; Kubota, Yasuhiko; Iso, Hiroyasu; Tamakoshi, Akiko; Tamakoshi, Akiko; Mori, Mitsuru; Kaneko, Yoshihiro; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Yamagishi, Kazumasa; Mikami, Haruo; Kurosawa, Michiko; Hoshiyama, Yoshiharu; Tanabe, Naohito; Tamakoshi, Koji; Wakai, Kenji; Ando, Masahiko; Suzuki, Koji; Hashimoto, Shuji; Yatsuya, Hiroshi; Kikuchi, Shogo; Wada, Yasuhiko; Kawamura, Takashi; Watanabe, Yoshiyuki; Ozasa, Kotaro; Mikami, Kazuya; Date, Chigusa; Sakata, Kiyomi; Kurozawa, Yoichi; Fujino, Yoshihisa; Shibata, Akira.

In: Journal of atherosclerosis and thrombosis, Vol. 26, No. 9, 01.01.2019, p. 775-782.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Self-reported eczema in relation with mortality from cardiovascular disease in Japanese

T2 - The Japan collaborative cohort study

AU - Nishida, Yoko

AU - Kubota, Yasuhiko

AU - Iso, Hiroyasu

AU - Tamakoshi, Akiko

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Kaneko, Yoshihiro

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Yamagishi, Kazumasa

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Wakai, Kenji

AU - Ando, Masahiko

AU - Suzuki, Koji

AU - Hashimoto, Shuji

AU - Yatsuya, Hiroshi

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Mikami, Kazuya

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Fujino, Yoshihisa

AU - Shibata, Akira

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Results: During the 6,389,818 person-years of follow-up, there were 1,174 deaths from coronary heart disease (CHD), 979 from heart failure, 366 from cardiac arrhythmia, 2,454 from total stroke, 1,357 from ischemic stroke, 1,013 from hemorrhagic stroke, and 201 from aortic aneurysm or dissection. The multivariable-adjusted model showed that individuals who “sometimes” or “often” had eczema had 0.82 (95%confidence interval (CI): 0.69–0.97) or 1.26 (95%CI: 1.01–1.56) times the risk of mortality from CHD, respectively, compared to those who “seldom” did. Individuals who “often” had 1.30 (95%CI: 1.05–1.61) times the risk of mortality from CHD, compared to those who “seldom or sometimes” did. There was no association of eczema with mortality from other CVD, or no interaction between eczema and sex or age, in relation to any CVD mortality risk. Conclusions: Self-reported frequent eczema was associated with increased risk of mortality from CHD, but not other major CVD, in a Japanese general population. Since steroid usage was not considered, future studies should include it as a potential confounding factor.

AB - Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Results: During the 6,389,818 person-years of follow-up, there were 1,174 deaths from coronary heart disease (CHD), 979 from heart failure, 366 from cardiac arrhythmia, 2,454 from total stroke, 1,357 from ischemic stroke, 1,013 from hemorrhagic stroke, and 201 from aortic aneurysm or dissection. The multivariable-adjusted model showed that individuals who “sometimes” or “often” had eczema had 0.82 (95%confidence interval (CI): 0.69–0.97) or 1.26 (95%CI: 1.01–1.56) times the risk of mortality from CHD, respectively, compared to those who “seldom” did. Individuals who “often” had 1.30 (95%CI: 1.05–1.61) times the risk of mortality from CHD, compared to those who “seldom or sometimes” did. There was no association of eczema with mortality from other CVD, or no interaction between eczema and sex or age, in relation to any CVD mortality risk. Conclusions: Self-reported frequent eczema was associated with increased risk of mortality from CHD, but not other major CVD, in a Japanese general population. Since steroid usage was not considered, future studies should include it as a potential confounding factor.

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DO - 10.5551/jat.46383

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