Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice

Tetsuji Okawa, Hideki Kamiya, Tatsuhito Himeno, Yusuke Seino, Shin Tsunekawa, Yoshitaka Hayashi, Norio Harada, Yuichiro Yamada, Nobuya Inagaki, Yutaka Seino, Yutaka Oiso, Jiro Nakamura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Aims/Introduction: Gastric inhibitory polypeptide (GIP) is an incretin secreted from the gastrointestinal tract after an ingestion of nutrients, and stimulates an insulin secretion from the pancreatic islets. Additionally, GIP has important roles in extrapancreatic tissues: fat accumulation in adipose tissue, neuroprotective effects in the central nervous system and an inhibition of bone resorption. In the current study, we investigated the effects of GIP signaling on the peripheral nervous system (PNS). Materials and Methods: First, the presence of the GIP receptor (GIPR) in mouse dorsal root ganglion (DRG) was evaluated utilizing immunohistochemical analysis, western blotting and reverse transcription polymerase chain reaction. DRG neurons of male wild-type mice (WT) were cultured with or without GIP, and their neurite lengths were quantified. Functions of the PNS were evaluated in GIPR-deficient mice (gipr-/-) and WT by using current perception thresholds (CPTs), Thermal Plantar Test (TPT), and motor (MNCV) and sensory nerve conduction velocity (SNCV, respectively). Sciatic nerve blood flow (SNBF) and plantar skin blood flow (PSBF) were also evaluated. Results: We confirmed the expression of GIPR in DRG neurons. The neurite outgrowths of DRG neurons were promoted by the GIP administrations. The gipr-/- showed impaired perception functions in the examination of CPTs and TPT. Both MNCV and SNCV were delayed in gipr-/- compared with these in WT. There was no difference in SNBF and PSBF between WT and gipr-/- Conclusions: Our findings show that the GIP signal could exert direct physiological roles in the PNS, which might be directly exerted on the PNS.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalJournal of Diabetes Investigation
Issue number1
Publication statusPublished - 01-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice'. Together they form a unique fingerprint.

Cite this