Sequence and expression of a metabotropic glutamate receptor

Masayuki Masu, Yasuto Tanabe, Kunihiro Tsuchida, Ryuichi Shigemoto, Shigetada Nakanishi

Research output: Contribution to journalArticlepeer-review

1049 Citations (Scopus)


The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

Original languageEnglish
Pages (from-to)760-765
Number of pages6
Issue number6312
Publication statusPublished - 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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