Sequence and expression of a metabotropic glutamate receptor

Masayuki Masu, Yasuto Tanabe, Kunihiro Tsuchida, Ryuichi Shigemoto, Shigetada Nakanishi

Research output: Contribution to journalArticle

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Abstract

The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

Original languageEnglish
Pages (from-to)760-765
Number of pages6
JournalNature
Volume349
Issue number6312
DOIs
Publication statusPublished - 01-01-1991

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Parahippocampal Gyrus
Metabotropic Glutamate Receptors
Inositol Phosphates
Purkinje Cells
Dentate Gyrus
G-Protein-Coupled Receptors
Signal Transduction
Complementary DNA
Messenger RNA
Membranes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R., & Nakanishi, S. (1991). Sequence and expression of a metabotropic glutamate receptor. Nature, 349(6312), 760-765. https://doi.org/10.1038/349760a0
Masu, Masayuki ; Tanabe, Yasuto ; Tsuchida, Kunihiro ; Shigemoto, Ryuichi ; Nakanishi, Shigetada. / Sequence and expression of a metabotropic glutamate receptor. In: Nature. 1991 ; Vol. 349, No. 6312. pp. 760-765.
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Masu, M, Tanabe, Y, Tsuchida, K, Shigemoto, R & Nakanishi, S 1991, 'Sequence and expression of a metabotropic glutamate receptor', Nature, vol. 349, no. 6312, pp. 760-765. https://doi.org/10.1038/349760a0

Sequence and expression of a metabotropic glutamate receptor. / Masu, Masayuki; Tanabe, Yasuto; Tsuchida, Kunihiro; Shigemoto, Ryuichi; Nakanishi, Shigetada.

In: Nature, Vol. 349, No. 6312, 01.01.1991, p. 760-765.

Research output: Contribution to journalArticle

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Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S. Sequence and expression of a metabotropic glutamate receptor. Nature. 1991 Jan 1;349(6312):760-765. https://doi.org/10.1038/349760a0