Sequence and expression of a metabotropic glutamate receptor

Masayuki Masu; Yasuto Tanabe; Kunihiro Tsuchida; Ryuichi Shigemoto; Shigetada Nakanishi

doi:10.1038/349760a0

Sequence and expression of a metabotropic glutamate receptor

Masayuki Masu, Yasuto Tanabe, Kunihiro Tsuchida, Ryuichi Shigemoto, Shigetada Nakanishi

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Abstract

The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca²⁺ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

Original language	English
Pages (from-to)	760-765
Number of pages	6
Journal	Nature
Volume	349
Issue number	6312
DOIs	https://doi.org/10.1038/349760a0
Publication status	Published - 1991
Externally published	Yes

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abstract = "The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.",

author = "Masayuki Masu and Yasuto Tanabe and Kunihiro Tsuchida and Ryuichi Shigemoto and Shigetada Nakanishi",

year = "1991",

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AU - Masu, Masayuki

AU - Tanabe, Yasuto

AU - Tsuchida, Kunihiro

AU - Shigemoto, Ryuichi

AU - Nakanishi, Shigetada

PY - 1991

Y1 - 1991

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AB - The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

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SP - 760

EP - 765

JO - Nature

JF - Nature

IS - 6312

ER -

Sequence and expression of a metabotropic glutamate receptor

Abstract

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