Sequence and expression of a metabotropic glutamate receptor

Masayuki Masu, Yasuto Tanabe, Kunihiro Tsuchida, Ryuichi Shigemoto, Shigetada Nakanishi

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Abstract

The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

Original languageEnglish
Pages (from-to)760-765
Number of pages6
JournalNature
Volume349
Issue number6312
DOIs
Publication statusPublished - 01-01-1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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    Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R., & Nakanishi, S. (1991). Sequence and expression of a metabotropic glutamate receptor. Nature, 349(6312), 760-765. https://doi.org/10.1038/349760a0