Sequence specificity of the human autonomously replicating sequence binding protein.

S. Izuta, M. Suzuki, K. Kojima, S. Yoshida

Research output: Contribution to journalArticle


We have previously found that the protein which bound to the essential region of human autonomously replicating sequences (ARS) could be the c-myc proto-oncogene product. Here we examined the binding specificity of human ARS binding protein purified from Burkitt's lymphoma Raji cells. Among several oligodeoxynucleotides, this protein bound to the fragments containing the sequence of 5'-CAPyCTCTNA-3'. Competition analysis revealed that the ARS binding protein could recognize not only the nucleotide sequences but also the high ordered structure.

Original languageEnglish
Pages (from-to)21-22
Number of pages2
JournalNucleic acids symposium series
Issue number21
Publication statusPublished - 1989
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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