Sequestration pattern of parasitized erythrocytes in cerebrum, mid-brain, and cerebellum of Plasmodium coatneyi-infected rhesus monkeys (Macaca mulatta)

Kyaw Sein Kyaw Kyaw Sein; A. E. Brown; Y. Maeno; C. D. Smith; K. D. Corcoran; P. Hansukjariya; H. K. Webster; M. Aikawa

doi:10.4269/ajtmh.1993.49.513

Sequestration pattern of parasitized erythrocytes in cerebrum, mid-brain, and cerebellum of Plasmodium coatneyi-infected rhesus monkeys (Macaca mulatta)

Kyaw Sein Kyaw Kyaw Sein, A. E. Brown, Y. Maeno, C. D. Smith, K. D. Corcoran, P. Hansukjariya, H. K. Webster, M. Aikawa

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Six rhesus monkeys (Macaca mulatta) infected with Plasmodium coatneyi were studied for parasitized red blood cell (PRBC) sequestration in microvessels of the brain. The degree of PRBC sequestration is different in the cerebral, mid-brain, and cerebellar microvessels, with sequestration occurring preferentially in the cerebellum. This pattern resembles that of PRBC sequestration in cerebral and cerebellar microvessels in human falciparum malaria. The morphologic appearance of sequestered cells under light and electron microscopy as well as the PRBC sequestration pattern bolsters the contention that the rhesus monkey infected with P. coatneyi is an appropriate primate model for the experimental study of human cerebral malaria.

Original language	English
Pages (from-to)	513-519
Number of pages	7
Journal	American Journal of Tropical Medicine and Hygiene
Volume	49
Issue number	4
DOIs	https://doi.org/10.4269/ajtmh.1993.49.513
Publication status	Published - 1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Parasitology
Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4269/ajtmh.1993.49.513

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Kyaw Kyaw Sein, K. S., Brown, A. E., Maeno, Y., Smith, C. D., Corcoran, K. D., Hansukjariya, P., Webster, H. K., & Aikawa, M. (1993). Sequestration pattern of parasitized erythrocytes in cerebrum, mid-brain, and cerebellum of Plasmodium coatneyi-infected rhesus monkeys (Macaca mulatta). American Journal of Tropical Medicine and Hygiene, 49(4), 513-519. https://doi.org/10.4269/ajtmh.1993.49.513

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title = "Sequestration pattern of parasitized erythrocytes in cerebrum, mid-brain, and cerebellum of Plasmodium coatneyi-infected rhesus monkeys (Macaca mulatta)",

abstract = "Six rhesus monkeys (Macaca mulatta) infected with Plasmodium coatneyi were studied for parasitized red blood cell (PRBC) sequestration in microvessels of the brain. The degree of PRBC sequestration is different in the cerebral, mid-brain, and cerebellar microvessels, with sequestration occurring preferentially in the cerebellum. This pattern resembles that of PRBC sequestration in cerebral and cerebellar microvessels in human falciparum malaria. The morphologic appearance of sequestered cells under light and electron microscopy as well as the PRBC sequestration pattern bolsters the contention that the rhesus monkey infected with P. coatneyi is an appropriate primate model for the experimental study of human cerebral malaria.",

author = "{Kyaw Kyaw Sein}, {Kyaw Sein} and Brown, {A. E.} and Y. Maeno and Smith, {C. D.} and Corcoran, {K. D.} and P. Hansukjariya and Webster, {H. K.} and M. Aikawa",

year = "1993",

doi = "10.4269/ajtmh.1993.49.513",

language = "English",

volume = "49",

pages = "513--519",

journal = "American Journal of Tropical Medicine and Hygiene",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

number = "4",

}

Kyaw Kyaw Sein, KS, Brown, AE, Maeno, Y, Smith, CD, Corcoran, KD, Hansukjariya, P, Webster, HK & Aikawa, M 1993, 'Sequestration pattern of parasitized erythrocytes in cerebrum, mid-brain, and cerebellum of Plasmodium coatneyi-infected rhesus monkeys (Macaca mulatta)', American Journal of Tropical Medicine and Hygiene, vol. 49, no. 4, pp. 513-519. https://doi.org/10.4269/ajtmh.1993.49.513

Sequestration pattern of parasitized erythrocytes in cerebrum, mid-brain, and cerebellum of Plasmodium coatneyi-infected rhesus monkeys (Macaca mulatta). / Kyaw Kyaw Sein, Kyaw Sein; Brown, A. E.; Maeno, Y. et al.
In: American Journal of Tropical Medicine and Hygiene, Vol. 49, No. 4, 1993, p. 513-519.

Research output: Contribution to journal › Article › peer-review

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T1 - Sequestration pattern of parasitized erythrocytes in cerebrum, mid-brain, and cerebellum of Plasmodium coatneyi-infected rhesus monkeys (Macaca mulatta)

AU - Kyaw Kyaw Sein, Kyaw Sein

AU - Brown, A. E.

AU - Maeno, Y.

AU - Smith, C. D.

AU - Corcoran, K. D.

AU - Hansukjariya, P.

AU - Webster, H. K.

AU - Aikawa, M.

PY - 1993

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AB - Six rhesus monkeys (Macaca mulatta) infected with Plasmodium coatneyi were studied for parasitized red blood cell (PRBC) sequestration in microvessels of the brain. The degree of PRBC sequestration is different in the cerebral, mid-brain, and cerebellar microvessels, with sequestration occurring preferentially in the cerebellum. This pattern resembles that of PRBC sequestration in cerebral and cerebellar microvessels in human falciparum malaria. The morphologic appearance of sequestered cells under light and electron microscopy as well as the PRBC sequestration pattern bolsters the contention that the rhesus monkey infected with P. coatneyi is an appropriate primate model for the experimental study of human cerebral malaria.

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Sequestration pattern of parasitized erythrocytes in cerebrum, mid-brain, and cerebellum of Plasmodium coatneyi-infected rhesus monkeys (Macaca mulatta)

Abstract

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UN SDGs

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