Serial change of 123I-Metaiodobenzylguanidine (MIBG) myocardial concentration in patients with dilated cardiomyopathy

K. Yamakado, K. Takeda, T. Kitano, T. Nakagawa, Y. T. Futagami Konishi, M. Hamada, T. Nakano, T. Ichihara

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Abstract

123I-Metaiodobenzylguanidine (MIBG) is expected to be useful agent for functional evaluation of the myocardial sympathetic innervation. The aim of this paper is to investigate serial change of 123I-MIBG myocardial concentration in patients (pts) with dilated cardiomyopathy (DCM) as compared with 201Tl upatke. Eight pts with DCM and six non-cardiac subjects (controls) were examined. After injection of 111 MBq (3 mCi) 201Tl and 111 MBq (3 mCi) 123I-MIBG, simultaneous myocardial imaging in anterior view was performed for both tracers in every 30-60 minutes during 5 hours (6 images). Myocardial uptake ratio per pixel to the injected dose was calculated for each tracer with background and cross-talk correction on each image. In pts with DCM, myocardial uptake ratio of 123I-MIBG did not differ significantly from that of control. The washout of 123I-MIBG from the myocardium, however, was significantly increased in pts with DCM as compared with controls. The % decrease of radioactivity in 3 hours was 46.9±13.8% in DCM, whereas 18.0±7.7% in controls (p<0.05). Especially, the decrease in the early phase (<1 hour) was significantly larger than controls (21.2±7.5% vs 5.3±4.0%, p<0.01). For 201Tl, on the other hand, neither uptake ratio nor washout rate, differed significantly between the two. In conclusion, the rapid washout of 12?3I-MIBG in the early phase may reflect some sympathetic dysfunction in pts with DCM.

Original languageEnglish
Pages (from-to)703-708
Number of pages6
JournalKakuigaku
Volume27
Issue number7
Publication statusPublished - 01-01-1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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    Yamakado, K., Takeda, K., Kitano, T., Nakagawa, T., Futagami Konishi, Y. T., Hamada, M., Nakano, T., & Ichihara, T. (1990). Serial change of 123I-Metaiodobenzylguanidine (MIBG) myocardial concentration in patients with dilated cardiomyopathy. Kakuigaku, 27(7), 703-708.