Serial optical frequency domain imaging in STEMI patients: The follow-up report of TROFI study

Hector M. García-García, Takashi Muramatsu, Shimpei Nakatani, Il Soo Lee, Niels Ramsing Holm, Leif Thuesen, Robert Jan Van Geuns, Martin Van Der Ent, Vladimir Borovicanin, Dragica Paunovic, Yoshinobu Onuma, Patrick W. Serruys

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31 Citations (Scopus)


Aims: To investigate the incidence of incomplete stent apposition and to explore the impact of the presence of thrombus and protruding plaque after stent implantation on neointima formation at follow-up in ST-segment elevation myocardial infarction (STEMI) patients with serial optical frequency domain imaging (OFDI) investigations. Methods and results: In a multi-centre study, 141 patients with ST elevation myocardial infarction, <12 h from on set were randomized to either PPCI with thrombectomy (TB) using an Eliminate catheter (TB: n = 71) or without TB(non-TB: n = 70).OFDI after drugeluting stentingwas performed using TERUMOOFDI system. Per protocol, at follow-up 49 patients segmentswere reimaged. At post-procedure and follow-up, there were no differences in stent and lumen areas between the two groups. At follow-up, per strut-level analysis, percentage of incompletely apposed struts was 0.42±0.94 vs. 0.38±0.77% (P = 0.76), and percentage of covered struts was 92.7±7.2 vs. 94.4±9.2% (P = 0.47) in the TB and non-TB groups, respectively. There was a positive correlation between intra-stent structure (ISS) volume at post-procedure and the neointima volume at 6-month follow-up (Pearson's r = 0.409, P = 0.04). Up to 12 months, there have been two and four patients having target vessel failure in the TB and in the non-TB groups, respectively. Conclusions: In patients with STEMI, therewere no significant differences in OFDI parameters between TB and non-TB groups at both post-procedure and 6-month follow-up. However, ISS volume at post-procedure was positively associated with neointimal volume at 6-month follow-up.

Original languageEnglish
Pages (from-to)987-995
Number of pages9
JournalEuropean Heart Journal Cardiovascular Imaging
Issue number9
Publication statusPublished - 09-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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