Sero- and molecular typing of Duffy blood group in Southeast Asians and Oceanians

Yuko Shimizu, Hiroko Ao, Augustinus Soemantri, Danai Tiwawech, Wannapa Settheetham-Ishida, Oktovianus Wellem Kayame, Masako Kimura, Tomoki Nishioka, Takafumi Ishida

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Duffy blood group was studied among malaria-endemic Thai and Indonesian populations: Hmong (n = 103), Akha (n = 218), Lisu (n = 44), Bugis (n = 95), Toraja (n = 77), Dani (n = 44), Mee (n = 80) and Irianese (n = 81). Phenotypes were studied by the ordinal indirect Coombs' test and genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) test. DNA analysis was used to type the Duffy blood group system. Deduced allele frequencies of Fya (0.958 ~ 1.0) based on the phenotypes were similar to those in other populations in Southeast Asia and Oceania. The study revealed the presence of Fya-antigens showing weak reactivity to antisera as well as a discrepancy between the genotype shown by the PCR-RFLP study and that predicted by the phenotype. The PCR-RFLP study also suggested the presence of an alternative genetic basis for the Fy(a - b -) phenotype, which differs from the African type.

Original languageEnglish
Pages (from-to)511-518
Number of pages8
JournalHuman Biology
Volume72
Issue number3
Publication statusPublished - 06-2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

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