Serological examination of human herpesvirus 6 and 7 in patients with coronary artery disease

Masaru Ihira, Tetsushi Yoshikawa, Junichi Ishii, Masanori Nomura, Hitoshi Hishida, Masahiro Ohashi, Yoshihiko Enomoto, Sadao Suga, Keiji Iida, Yumiko Saito, Yukihiro Nishiyama, Yoshizo Asano

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Fifty-three (96%) of 55 patients with coronary artery stenosis were positive for serum anti-HHV-6 IgG, and 50 (91%) of these patients had anti-HHV-7 IgG. The number of cases sero-positive for HHV-6 and -7 in the 54 age matched control volunteers was 52 (96%) and 53 (98%), respectively. No statistical difference in the seroprevalence of the viruses existed between the patients and the control group. The mean geometric titer (log10) of anti-HHV-6 IgG in both the patients and controls were the same (1.4) (P=0.845), whereas anti-HHV-7 titers were 1.4 and 1.5, respectively (P=0.161). Ten (18%) of the 55 patients had anti-HHV-6 IgM; eight (15%) of the 54 control volunteers were also positive (P=0.636). Three (5%) of the 55 patients had anti-HHV-7 IgM, whereas 3 (6%) of the 54 control volunteers had detectable serum antibody (P=0.691). Forty-seven of the 55 patients were examined by follow-up angiographic evaluation to clarify the association between viral infection and restenosis following balloon angioplasty. Fifteen of these patients developed restenosis, as determined by angiography. The mean geometric titer (log10) of anti-HHV-6 IgG were 1.3 and 1.4 in patients with restenosis and those without restenosis, respectively (P=0.724). The mean geometric titer (log10) of anti-HHV-7 IgG in patients with restenosis was not significantly higher (1.5) than in patients without restenosis (1.3) (P=0.099). Three (20%) of the 15 patients affected by restenosis had anti-HHV-6 IgM; five (16%) of the 32 control patients also had the antibody (P=0.965). One (7%) of the 15 patients with restenosis and 2 (6%) of the 32 patients without restenosis had anti-HHV-7 IgM (P= 0.558). The present study demonstrates that HHV-6 and -7 reactivation is not associated with the establishment of coronary artery stenosis and restenosis following balloon angioplasty.

Original languageEnglish
Pages (from-to)534-537
Number of pages4
JournalJournal of Medical Virology
Volume67
Issue number4
DOIs
Publication statusPublished - 20-07-2002

Fingerprint

Human Herpesvirus 7
Human Herpesvirus 6
Coronary Artery Disease
Immunoglobulin G
Immunoglobulin M
Volunteers
Balloon Angioplasty
Coronary Stenosis
Coronary Restenosis
Antibodies

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Ihira, Masaru ; Yoshikawa, Tetsushi ; Ishii, Junichi ; Nomura, Masanori ; Hishida, Hitoshi ; Ohashi, Masahiro ; Enomoto, Yoshihiko ; Suga, Sadao ; Iida, Keiji ; Saito, Yumiko ; Nishiyama, Yukihiro ; Asano, Yoshizo. / Serological examination of human herpesvirus 6 and 7 in patients with coronary artery disease. In: Journal of Medical Virology. 2002 ; Vol. 67, No. 4. pp. 534-537.
@article{168853f8ab394f32b830666f8170b02a,
title = "Serological examination of human herpesvirus 6 and 7 in patients with coronary artery disease",
abstract = "Fifty-three (96{\%}) of 55 patients with coronary artery stenosis were positive for serum anti-HHV-6 IgG, and 50 (91{\%}) of these patients had anti-HHV-7 IgG. The number of cases sero-positive for HHV-6 and -7 in the 54 age matched control volunteers was 52 (96{\%}) and 53 (98{\%}), respectively. No statistical difference in the seroprevalence of the viruses existed between the patients and the control group. The mean geometric titer (log10) of anti-HHV-6 IgG in both the patients and controls were the same (1.4) (P=0.845), whereas anti-HHV-7 titers were 1.4 and 1.5, respectively (P=0.161). Ten (18{\%}) of the 55 patients had anti-HHV-6 IgM; eight (15{\%}) of the 54 control volunteers were also positive (P=0.636). Three (5{\%}) of the 55 patients had anti-HHV-7 IgM, whereas 3 (6{\%}) of the 54 control volunteers had detectable serum antibody (P=0.691). Forty-seven of the 55 patients were examined by follow-up angiographic evaluation to clarify the association between viral infection and restenosis following balloon angioplasty. Fifteen of these patients developed restenosis, as determined by angiography. The mean geometric titer (log10) of anti-HHV-6 IgG were 1.3 and 1.4 in patients with restenosis and those without restenosis, respectively (P=0.724). The mean geometric titer (log10) of anti-HHV-7 IgG in patients with restenosis was not significantly higher (1.5) than in patients without restenosis (1.3) (P=0.099). Three (20{\%}) of the 15 patients affected by restenosis had anti-HHV-6 IgM; five (16{\%}) of the 32 control patients also had the antibody (P=0.965). One (7{\%}) of the 15 patients with restenosis and 2 (6{\%}) of the 32 patients without restenosis had anti-HHV-7 IgM (P= 0.558). The present study demonstrates that HHV-6 and -7 reactivation is not associated with the establishment of coronary artery stenosis and restenosis following balloon angioplasty.",
author = "Masaru Ihira and Tetsushi Yoshikawa and Junichi Ishii and Masanori Nomura and Hitoshi Hishida and Masahiro Ohashi and Yoshihiko Enomoto and Sadao Suga and Keiji Iida and Yumiko Saito and Yukihiro Nishiyama and Yoshizo Asano",
year = "2002",
month = "7",
day = "20",
doi = "10.1002/jmv.10134",
language = "English",
volume = "67",
pages = "534--537",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "4",

}

Ihira, M, Yoshikawa, T, Ishii, J, Nomura, M, Hishida, H, Ohashi, M, Enomoto, Y, Suga, S, Iida, K, Saito, Y, Nishiyama, Y & Asano, Y 2002, 'Serological examination of human herpesvirus 6 and 7 in patients with coronary artery disease', Journal of Medical Virology, vol. 67, no. 4, pp. 534-537. https://doi.org/10.1002/jmv.10134

Serological examination of human herpesvirus 6 and 7 in patients with coronary artery disease. / Ihira, Masaru; Yoshikawa, Tetsushi; Ishii, Junichi; Nomura, Masanori; Hishida, Hitoshi; Ohashi, Masahiro; Enomoto, Yoshihiko; Suga, Sadao; Iida, Keiji; Saito, Yumiko; Nishiyama, Yukihiro; Asano, Yoshizo.

In: Journal of Medical Virology, Vol. 67, No. 4, 20.07.2002, p. 534-537.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serological examination of human herpesvirus 6 and 7 in patients with coronary artery disease

AU - Ihira, Masaru

AU - Yoshikawa, Tetsushi

AU - Ishii, Junichi

AU - Nomura, Masanori

AU - Hishida, Hitoshi

AU - Ohashi, Masahiro

AU - Enomoto, Yoshihiko

AU - Suga, Sadao

AU - Iida, Keiji

AU - Saito, Yumiko

AU - Nishiyama, Yukihiro

AU - Asano, Yoshizo

PY - 2002/7/20

Y1 - 2002/7/20

N2 - Fifty-three (96%) of 55 patients with coronary artery stenosis were positive for serum anti-HHV-6 IgG, and 50 (91%) of these patients had anti-HHV-7 IgG. The number of cases sero-positive for HHV-6 and -7 in the 54 age matched control volunteers was 52 (96%) and 53 (98%), respectively. No statistical difference in the seroprevalence of the viruses existed between the patients and the control group. The mean geometric titer (log10) of anti-HHV-6 IgG in both the patients and controls were the same (1.4) (P=0.845), whereas anti-HHV-7 titers were 1.4 and 1.5, respectively (P=0.161). Ten (18%) of the 55 patients had anti-HHV-6 IgM; eight (15%) of the 54 control volunteers were also positive (P=0.636). Three (5%) of the 55 patients had anti-HHV-7 IgM, whereas 3 (6%) of the 54 control volunteers had detectable serum antibody (P=0.691). Forty-seven of the 55 patients were examined by follow-up angiographic evaluation to clarify the association between viral infection and restenosis following balloon angioplasty. Fifteen of these patients developed restenosis, as determined by angiography. The mean geometric titer (log10) of anti-HHV-6 IgG were 1.3 and 1.4 in patients with restenosis and those without restenosis, respectively (P=0.724). The mean geometric titer (log10) of anti-HHV-7 IgG in patients with restenosis was not significantly higher (1.5) than in patients without restenosis (1.3) (P=0.099). Three (20%) of the 15 patients affected by restenosis had anti-HHV-6 IgM; five (16%) of the 32 control patients also had the antibody (P=0.965). One (7%) of the 15 patients with restenosis and 2 (6%) of the 32 patients without restenosis had anti-HHV-7 IgM (P= 0.558). The present study demonstrates that HHV-6 and -7 reactivation is not associated with the establishment of coronary artery stenosis and restenosis following balloon angioplasty.

AB - Fifty-three (96%) of 55 patients with coronary artery stenosis were positive for serum anti-HHV-6 IgG, and 50 (91%) of these patients had anti-HHV-7 IgG. The number of cases sero-positive for HHV-6 and -7 in the 54 age matched control volunteers was 52 (96%) and 53 (98%), respectively. No statistical difference in the seroprevalence of the viruses existed between the patients and the control group. The mean geometric titer (log10) of anti-HHV-6 IgG in both the patients and controls were the same (1.4) (P=0.845), whereas anti-HHV-7 titers were 1.4 and 1.5, respectively (P=0.161). Ten (18%) of the 55 patients had anti-HHV-6 IgM; eight (15%) of the 54 control volunteers were also positive (P=0.636). Three (5%) of the 55 patients had anti-HHV-7 IgM, whereas 3 (6%) of the 54 control volunteers had detectable serum antibody (P=0.691). Forty-seven of the 55 patients were examined by follow-up angiographic evaluation to clarify the association between viral infection and restenosis following balloon angioplasty. Fifteen of these patients developed restenosis, as determined by angiography. The mean geometric titer (log10) of anti-HHV-6 IgG were 1.3 and 1.4 in patients with restenosis and those without restenosis, respectively (P=0.724). The mean geometric titer (log10) of anti-HHV-7 IgG in patients with restenosis was not significantly higher (1.5) than in patients without restenosis (1.3) (P=0.099). Three (20%) of the 15 patients affected by restenosis had anti-HHV-6 IgM; five (16%) of the 32 control patients also had the antibody (P=0.965). One (7%) of the 15 patients with restenosis and 2 (6%) of the 32 patients without restenosis had anti-HHV-7 IgM (P= 0.558). The present study demonstrates that HHV-6 and -7 reactivation is not associated with the establishment of coronary artery stenosis and restenosis following balloon angioplasty.

UR - http://www.scopus.com/inward/record.url?scp=0036304795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036304795&partnerID=8YFLogxK

U2 - 10.1002/jmv.10134

DO - 10.1002/jmv.10134

M3 - Article

VL - 67

SP - 534

EP - 537

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 4

ER -