Serotonergic involvement in phencyclidine-induced behaviors

Toshitaka Nabeshima, K. Yamaguchi, M. Hiramatsu, M. Amano, H. Furukawa, T. Kameyama

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Administration of 5–10 mg/kg of phencyclidine (PCP) caused stereotyped behaviors including sniffing, backpedalling, head weaving and turning in rats. The PCP-induced stereotyped behaviors (backpedalling, head weaving and turning) were attenuated by serotonin (5-HT) depleters [reserpine, p-chlorophenylalanine, p-chloroamphetamine (PCA)] and 5-HT receptor antagonist (cyproheptadine). PCP-induced head weaving and turning were potentiated by 5-HT precursor (tryptophan) and 5-HT releaser (PCA). PCP-induced head weaving were potentiated also by monoamine oxidase inhibitor (pargyline) and 5-HT reuptake inhibitor (imipramine). PCP 5–10 mg/kg significantly increased the content of 5-HT in the thalamus/hypothalamus at 30 and 60 min after the injection, except PCP 5 mg/kg at 60 min. PCP 7.5 and 10 mg/kg increased the rate of increment of 5-HT by pargyline in the thalamus/hypothalamus at 30 and 60 min after the injection, respectively. PCP 10 mg/kg significantly increased the contents of 5-HIAA in the striatum and thalamus/hypothalamus at 30 min, but decreased that of 5-HIAA in all discrete brain areas except the striatum at 60 min after the injection. PCP also significantly prevented the depletion of 5-HT by PCA in all discrete brain areas except the stratium at 60 min after the injection. Prom these results, PCP-induced stereotyped behaviors are related to an increased serotonergic neuronal activity due to 5-HT releasing action and/or inhibitory action of 5-HT uptake by this drug.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalPharmacology Biochemistry and Behavior
Volume21
Issue number3
DOIs
Publication statusPublished - 01-01-1984
Externally publishedYes

Fingerprint

Phencyclidine
Serotonin
p-Chloroamphetamine
Stereotyped Behavior
Thalamus
Head
Hypothalamus
Pargyline
Injections
Hydroxyindoleacetic Acid
Brain
Fenclonine
Cyproheptadine
Serotonin Antagonists
Monoamine Oxidase Inhibitors
Imipramine
Serotonin Receptors
Reserpine
Tryptophan
Rats

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Nabeshima, Toshitaka ; Yamaguchi, K. ; Hiramatsu, M. ; Amano, M. ; Furukawa, H. ; Kameyama, T. / Serotonergic involvement in phencyclidine-induced behaviors. In: Pharmacology Biochemistry and Behavior. 1984 ; Vol. 21, No. 3. pp. 401-408.
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abstract = "Administration of 5–10 mg/kg of phencyclidine (PCP) caused stereotyped behaviors including sniffing, backpedalling, head weaving and turning in rats. The PCP-induced stereotyped behaviors (backpedalling, head weaving and turning) were attenuated by serotonin (5-HT) depleters [reserpine, p-chlorophenylalanine, p-chloroamphetamine (PCA)] and 5-HT receptor antagonist (cyproheptadine). PCP-induced head weaving and turning were potentiated by 5-HT precursor (tryptophan) and 5-HT releaser (PCA). PCP-induced head weaving were potentiated also by monoamine oxidase inhibitor (pargyline) and 5-HT reuptake inhibitor (imipramine). PCP 5–10 mg/kg significantly increased the content of 5-HT in the thalamus/hypothalamus at 30 and 60 min after the injection, except PCP 5 mg/kg at 60 min. PCP 7.5 and 10 mg/kg increased the rate of increment of 5-HT by pargyline in the thalamus/hypothalamus at 30 and 60 min after the injection, respectively. PCP 10 mg/kg significantly increased the contents of 5-HIAA in the striatum and thalamus/hypothalamus at 30 min, but decreased that of 5-HIAA in all discrete brain areas except the striatum at 60 min after the injection. PCP also significantly prevented the depletion of 5-HT by PCA in all discrete brain areas except the stratium at 60 min after the injection. Prom these results, PCP-induced stereotyped behaviors are related to an increased serotonergic neuronal activity due to 5-HT releasing action and/or inhibitory action of 5-HT uptake by this drug.",
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Nabeshima, T, Yamaguchi, K, Hiramatsu, M, Amano, M, Furukawa, H & Kameyama, T 1984, 'Serotonergic involvement in phencyclidine-induced behaviors', Pharmacology Biochemistry and Behavior, vol. 21, no. 3, pp. 401-408. https://doi.org/10.1016/S0091-3057(84)80102-1

Serotonergic involvement in phencyclidine-induced behaviors. / Nabeshima, Toshitaka; Yamaguchi, K.; Hiramatsu, M.; Amano, M.; Furukawa, H.; Kameyama, T.

In: Pharmacology Biochemistry and Behavior, Vol. 21, No. 3, 01.01.1984, p. 401-408.

Research output: Contribution to journalArticle

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