Serotonin 1A receptor gene, schizophrenia and bipolar disorder

An association study and meta-analysis

Taro Kishi, Tomo Okochi, Tomoko Tsunoka, Takenori Okumura, Tsuyoshi Kitajima, Kunihiro Kawashima, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Naitoh, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

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Abstract

Several investigations have reported associations between serotonin 1A (5-HT1A) receptor and major psychiatric disorders, such as schizophrenia and bipolar disorder (BP), making the 5-HT1A receptor gene (HTR1A) a good candidate gene for the pathophysiology of schizophrenia and BP. To evaluate the association between HTR1A and schizophrenia and BP, we conducted a case-control study of Japanese population samples with two single- nucleotide polymorphisms (SNPs), including rs6295 (C-1019G) in HTR1A. In addition, we conducted a meta-analysis of rs6295, which has been examined in other studies. Using one functional single- nucleotide polymorphism (SNP; rs6295) and one tagging SNP (rs878567), we conducted a genetic association analysis of case-control samples (857 schizophrenic patients, 1028 BP patients and 1810 controls) in the Japanese population. Two association studies for schizophrenia and three association studies for BP, including this study, met our criteria for the meta-analysis of rs6295. We found an association between HTR1A and Japanese BP in a haplotype-wise analysis, the significance of which remained after Bonferroni correction. In addition, we detected an association between rs6295 and BP in the meta-analysis (fixed model: P(Z) = 0.000400). However, we did not detect an association between HTR1A and schizophrenia in the allele/genotype-wise, haplotype-wise or meta-analysis. HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population. In the meta-analysis, rs6295 in HTR1A was associated with BP patients.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalPsychiatry Research
Volume185
Issue number1-2
DOIs
Publication statusPublished - 30-01-2011

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Receptor, Serotonin, 5-HT1A
Bipolar Disorder
Meta-Analysis
Schizophrenia
Genes
Single Nucleotide Polymorphism
Haplotypes
Population
Psychiatry
Case-Control Studies
Alleles
Genotype

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Kishi, Taro ; Okochi, Tomo ; Tsunoka, Tomoko ; Okumura, Takenori ; Kitajima, Tsuyoshi ; Kawashima, Kunihiro ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Naitoh, Hiroshi ; Inada, Toshiya ; Kunugi, Hiroshi ; Kato, Tadafumi ; Yoshikawa, Takeo ; Ujike, Hiroshi ; Ozaki, Norio ; Iwata, Nakao. / Serotonin 1A receptor gene, schizophrenia and bipolar disorder : An association study and meta-analysis. In: Psychiatry Research. 2011 ; Vol. 185, No. 1-2. pp. 20-26.
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Kishi, T, Okochi, T, Tsunoka, T, Okumura, T, Kitajima, T, Kawashima, K, Yamanouchi, Y, Kinoshita, Y, Naitoh, H, Inada, T, Kunugi, H, Kato, T, Yoshikawa, T, Ujike, H, Ozaki, N & Iwata, N 2011, 'Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis', Psychiatry Research, vol. 185, no. 1-2, pp. 20-26. https://doi.org/10.1016/j.psychres.2010.06.003

Serotonin 1A receptor gene, schizophrenia and bipolar disorder : An association study and meta-analysis. / Kishi, Taro; Okochi, Tomo; Tsunoka, Tomoko; Okumura, Takenori; Kitajima, Tsuyoshi; Kawashima, Kunihiro; Yamanouchi, Yoshio; Kinoshita, Yoko; Naitoh, Hiroshi; Inada, Toshiya; Kunugi, Hiroshi; Kato, Tadafumi; Yoshikawa, Takeo; Ujike, Hiroshi; Ozaki, Norio; Iwata, Nakao.

In: Psychiatry Research, Vol. 185, No. 1-2, 30.01.2011, p. 20-26.

Research output: Contribution to journalArticle

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T1 - Serotonin 1A receptor gene, schizophrenia and bipolar disorder

T2 - An association study and meta-analysis

AU - Kishi, Taro

AU - Okochi, Tomo

AU - Tsunoka, Tomoko

AU - Okumura, Takenori

AU - Kitajima, Tsuyoshi

AU - Kawashima, Kunihiro

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Naitoh, Hiroshi

AU - Inada, Toshiya

AU - Kunugi, Hiroshi

AU - Kato, Tadafumi

AU - Yoshikawa, Takeo

AU - Ujike, Hiroshi

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2011/1/30

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N2 - Several investigations have reported associations between serotonin 1A (5-HT1A) receptor and major psychiatric disorders, such as schizophrenia and bipolar disorder (BP), making the 5-HT1A receptor gene (HTR1A) a good candidate gene for the pathophysiology of schizophrenia and BP. To evaluate the association between HTR1A and schizophrenia and BP, we conducted a case-control study of Japanese population samples with two single- nucleotide polymorphisms (SNPs), including rs6295 (C-1019G) in HTR1A. In addition, we conducted a meta-analysis of rs6295, which has been examined in other studies. Using one functional single- nucleotide polymorphism (SNP; rs6295) and one tagging SNP (rs878567), we conducted a genetic association analysis of case-control samples (857 schizophrenic patients, 1028 BP patients and 1810 controls) in the Japanese population. Two association studies for schizophrenia and three association studies for BP, including this study, met our criteria for the meta-analysis of rs6295. We found an association between HTR1A and Japanese BP in a haplotype-wise analysis, the significance of which remained after Bonferroni correction. In addition, we detected an association between rs6295 and BP in the meta-analysis (fixed model: P(Z) = 0.000400). However, we did not detect an association between HTR1A and schizophrenia in the allele/genotype-wise, haplotype-wise or meta-analysis. HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population. In the meta-analysis, rs6295 in HTR1A was associated with BP patients.

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