Serotonin-2A receptor gene T102C polymorphism in patients with dyspeptic symptoms

Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is unclear. Serotonin (5-HT) is expressed in gastro-intestinal tract and modulates the sensory-motor functions in the digestive tract. Genetic association has been reported between C102T polymorphism in the gene encoding 5-HT 2A receptor (5HTR2A) and various diseases. We aimed to clarify the association between 5HTR2A C102T polymorphism and dyspeptic symptom in a Japanese population. Methodology: 91 dyspeptics and 93 non-dyspeptic subjects enrolled in this study. Dyspeptic symptoms were divided into 9 categories. 5HTR2A gene T102C polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: In the non-dyspeptics, the 5HTR2A geno, type distribution was 21TT (22.6%), 50TC (53.8%), and 22CC (23.6%). Meanwhile, the 5HTR2A genotype distribution in dyspeptics was 30 TT (33.0%), 40 TC (43.9%), and 21 CC (23.1%). There was no significant difference between the two groups in the genotype distribution. We did not find any association between 5HTR2A genotypes and dyspeptic patients in different gender and H. pylori infection status. Also, no correlation was found between 5HTR2A polymorphism and any of the 9 different dyspeptic symptoms. Conclusions: Our results suggest that 5HTR2A polymorphism is unlikely to be associated with susceptibility of dyspeptic symptoms. The role of genetics to the development of dyspepsia needs further evaluation.