TY - JOUR
T1 - Serotonin 6 receptor gene and mood disorders
T2 - Case-control study and meta-analysis
AU - Fukuo, Yasuhisa
AU - Kishi, Taro
AU - Yoshimura, Reiji
AU - Kitajima, Tsuyoshi
AU - Okochi, Tomo
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Kawashima, Kunihiro
AU - Naitoh, Hiroshi
AU - Umene-Nakano, Wakako
AU - Inada, Toshiya
AU - Kunugi, Hiroshi
AU - Kato, Tadafumi
AU - Yoshikawa, Takeo
AU - Ujike, Hiroshi
AU - Nakamura, Jun
AU - Ozaki, Norio
AU - Iwata, Nakao
N1 - Funding Information:
We thank Ms. M. Miyata and Ms. S. Ishihara for their technical support. This work was supported in part by research grants from the Japan Ministry of Education, Culture, Sports, Science and Technology , the Ministry of Health, Labor and Welfare , and the Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation).
PY - 2010/7
Y1 - 2010/7
N2 - Several evidence suggests that alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this receptor and mood disorders in the future.
AB - Several evidence suggests that alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this receptor and mood disorders in the future.
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U2 - 10.1016/j.neures.2010.04.003
DO - 10.1016/j.neures.2010.04.003
M3 - Article
C2 - 20394784
AN - SCOPUS:77953361787
SN - 0168-0102
VL - 67
SP - 250
EP - 255
JO - Neuroscience Research
JF - Neuroscience Research
IS - 3
ER -