Serotonin 6 receptor gene and schizophrenia: Case-control study and meta-analysis

Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Norio Ozaki, Giovanna M. Musso, John M. Kane, Christoph U. Correll, Nakao Iwata

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Objectives Several lines of evidence suggest that genetic alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 receptors and schizophrenia both in a case-control study and a meta-analysis. Methods We conducted an association study of the 5-HT6 receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011. Results There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia. Conclusions Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalHuman Psychopharmacology
Volume27
Issue number1
DOIs
Publication statusPublished - 01-01-2012

Fingerprint

Meta-Analysis
Case-Control Studies
Schizophrenia
Genes
Single Nucleotide Polymorphism
Logistic Models
Genotype
Regression Analysis
serotonin 6 receptor
PubMed
Haplotypes
Serotonin

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Kishi, Taro ; Fukuo, Yasuhisa ; Okochi, Tomo ; Kawashima, Kunihiro ; Kitajima, Tsuyoshi ; Inada, Toshiya ; Ozaki, Norio ; Musso, Giovanna M. ; Kane, John M. ; Correll, Christoph U. ; Iwata, Nakao. / Serotonin 6 receptor gene and schizophrenia : Case-control study and meta-analysis. In: Human Psychopharmacology. 2012 ; Vol. 27, No. 1. pp. 63-69.
@article{1808aac941954763ae1eefda49b9de6b,
title = "Serotonin 6 receptor gene and schizophrenia: Case-control study and meta-analysis",
abstract = "Objectives Several lines of evidence suggest that genetic alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 receptors and schizophrenia both in a case-control study and a meta-analysis. Methods We conducted an association study of the 5-HT6 receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011. Results There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia. Conclusions Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia.",
author = "Taro Kishi and Yasuhisa Fukuo and Tomo Okochi and Kunihiro Kawashima and Tsuyoshi Kitajima and Toshiya Inada and Norio Ozaki and Musso, {Giovanna M.} and Kane, {John M.} and Correll, {Christoph U.} and Nakao Iwata",
year = "2012",
month = "1",
day = "1",
doi = "10.1002/hup.1266",
language = "English",
volume = "27",
pages = "63--69",
journal = "Human Psychopharmacology",
issn = "0885-6222",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

Kishi, T, Fukuo, Y, Okochi, T, Kawashima, K, Kitajima, T, Inada, T, Ozaki, N, Musso, GM, Kane, JM, Correll, CU & Iwata, N 2012, 'Serotonin 6 receptor gene and schizophrenia: Case-control study and meta-analysis', Human Psychopharmacology, vol. 27, no. 1, pp. 63-69. https://doi.org/10.1002/hup.1266

Serotonin 6 receptor gene and schizophrenia : Case-control study and meta-analysis. / Kishi, Taro; Fukuo, Yasuhisa; Okochi, Tomo; Kawashima, Kunihiro; Kitajima, Tsuyoshi; Inada, Toshiya; Ozaki, Norio; Musso, Giovanna M.; Kane, John M.; Correll, Christoph U.; Iwata, Nakao.

In: Human Psychopharmacology, Vol. 27, No. 1, 01.01.2012, p. 63-69.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Serotonin 6 receptor gene and schizophrenia

T2 - Case-control study and meta-analysis

AU - Kishi, Taro

AU - Fukuo, Yasuhisa

AU - Okochi, Tomo

AU - Kawashima, Kunihiro

AU - Kitajima, Tsuyoshi

AU - Inada, Toshiya

AU - Ozaki, Norio

AU - Musso, Giovanna M.

AU - Kane, John M.

AU - Correll, Christoph U.

AU - Iwata, Nakao

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Objectives Several lines of evidence suggest that genetic alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 receptors and schizophrenia both in a case-control study and a meta-analysis. Methods We conducted an association study of the 5-HT6 receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011. Results There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia. Conclusions Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia.

AB - Objectives Several lines of evidence suggest that genetic alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 receptors and schizophrenia both in a case-control study and a meta-analysis. Methods We conducted an association study of the 5-HT6 receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011. Results There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia. Conclusions Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=84856336129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856336129&partnerID=8YFLogxK

U2 - 10.1002/hup.1266

DO - 10.1002/hup.1266

M3 - Review article

C2 - 22745941

AN - SCOPUS:84856336129

VL - 27

SP - 63

EP - 69

JO - Human Psychopharmacology

JF - Human Psychopharmacology

SN - 0885-6222

IS - 1

ER -