TY - JOUR
T1 - Serum γ-glutamyltransferase and mortality due to cardiovascular disease in Japanese men and women
AU - The EPOCH-JAPAN Research Group
AU - Li, Yuanying
AU - Iso, Hiroyasu
AU - Cui, Renzhe
AU - Murakami, Yoshitaka
AU - Yatsuya, Hiroshi
AU - Miura, Katsuyuki
AU - Nagasawa, Shin Ya
AU - Ueshima, Hirotsugu
AU - Okamura, Tomonori
AU - Imai, Yutaka
AU - Ohkubo, Takayoshi
AU - Irie, Fujiko
AU - Kitamura, Akihiko
AU - Kiyohara, Yutaka
AU - Nakagawa, Hideaki
AU - Nakayama, Takeo
AU - Okayama, Akira
AU - Sairenchi, Toshimi
AU - Saitoh, Shigeyuki
AU - Sakata, Kiyomi
AU - Tamakoshi, Akiko
AU - Tsuji, Ichiro
AU - Yamada, Michiko
AU - Kiyama, Masahiko
AU - Miyamoto, Yoshihiro
AU - Ishikawa, Shizukiyo
N1 - Publisher Copyright:
© 2016, Japan Atherosclerosis Society. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Aim: Whether the association between serum γ-glutamyltransferase (γ-GTP) levels and total cardiovascular disease (CVD) mortality is independent of alcohol drinking in East Asian populations is not well known. We conducted a pooled analysis of Japanese men and women that enabled an analysis restricted to never-drinkers. Methods: A total of 15,987 men and 25,053 women aged 40-79 years, pooled from seven cohort studies throughout Japan, were followed-up to examine sex-specific relationship between serum γ -GTP levels and total CVD mortality. Cox regression model was used that was adjusted for age, smoking status, body mass index, and systolic blood pressure and serum triglyceride, total cholesterol, aspartate aminotransferase, and alanine aminotransferase levels. Results: During an average follow-up of 8.7 years, we documented 361 and 340 deaths from total CVD, 146 and 168 from stroke, and 101 and 53 from coronary heart disease (CHD) for men and women, respectively. Among the never-drinkers, hazard ratios (HRs) for mortality for one standard deviation of log-γ-GTP for men were 1.89 (1.00-3.58) for stroke, 1.04 (0.57-1.90) for CHD, and 1.43 (1.04-1.96) for total CVD. For women, HRs were 1.28 (1.06-1.54), 1.81 (1.34-2.44), and 1.30 (1.14-1.49), respectively. Conclusion: γ-GTP may be a risk factor for total CVD mortality independent of alcohol drinking status in Japanese men and women.
AB - Aim: Whether the association between serum γ-glutamyltransferase (γ-GTP) levels and total cardiovascular disease (CVD) mortality is independent of alcohol drinking in East Asian populations is not well known. We conducted a pooled analysis of Japanese men and women that enabled an analysis restricted to never-drinkers. Methods: A total of 15,987 men and 25,053 women aged 40-79 years, pooled from seven cohort studies throughout Japan, were followed-up to examine sex-specific relationship between serum γ -GTP levels and total CVD mortality. Cox regression model was used that was adjusted for age, smoking status, body mass index, and systolic blood pressure and serum triglyceride, total cholesterol, aspartate aminotransferase, and alanine aminotransferase levels. Results: During an average follow-up of 8.7 years, we documented 361 and 340 deaths from total CVD, 146 and 168 from stroke, and 101 and 53 from coronary heart disease (CHD) for men and women, respectively. Among the never-drinkers, hazard ratios (HRs) for mortality for one standard deviation of log-γ-GTP for men were 1.89 (1.00-3.58) for stroke, 1.04 (0.57-1.90) for CHD, and 1.43 (1.04-1.96) for total CVD. For women, HRs were 1.28 (1.06-1.54), 1.81 (1.34-2.44), and 1.30 (1.14-1.49), respectively. Conclusion: γ-GTP may be a risk factor for total CVD mortality independent of alcohol drinking status in Japanese men and women.
UR - http://www.scopus.com/inward/record.url?scp=84976645143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976645143&partnerID=8YFLogxK
U2 - 10.5551/jat.32698
DO - 10.5551/jat.32698
M3 - Article
C2 - 26875518
AN - SCOPUS:84976645143
SN - 1340-3478
VL - 23
SP - 792
EP - 799
JO - Journal of atherosclerosis and thrombosis
JF - Journal of atherosclerosis and thrombosis
IS - 7
ER -
