Serum γ-glutamyltransferase and mortality due to cardiovascular disease in Japanese men and women

The EPOCH-JAPAN Research Group

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim: Whether the association between serum γ-glutamyltransferase (γ-GTP) levels and total cardiovascular disease (CVD) mortality is independent of alcohol drinking in East Asian populations is not well known. We conducted a pooled analysis of Japanese men and women that enabled an analysis restricted to never-drinkers. Methods: A total of 15,987 men and 25,053 women aged 40-79 years, pooled from seven cohort studies throughout Japan, were followed-up to examine sex-specific relationship between serum γ -GTP levels and total CVD mortality. Cox regression model was used that was adjusted for age, smoking status, body mass index, and systolic blood pressure and serum triglyceride, total cholesterol, aspartate aminotransferase, and alanine aminotransferase levels. Results: During an average follow-up of 8.7 years, we documented 361 and 340 deaths from total CVD, 146 and 168 from stroke, and 101 and 53 from coronary heart disease (CHD) for men and women, respectively. Among the never-drinkers, hazard ratios (HRs) for mortality for one standard deviation of log-γ-GTP for men were 1.89 (1.00-3.58) for stroke, 1.04 (0.57-1.90) for CHD, and 1.43 (1.04-1.96) for total CVD. For women, HRs were 1.28 (1.06-1.54), 1.81 (1.34-2.44), and 1.30 (1.14-1.49), respectively. Conclusion: γ-GTP may be a risk factor for total CVD mortality independent of alcohol drinking status in Japanese men and women.

Original languageEnglish
Pages (from-to)792-799
Number of pages8
JournalJournal of atherosclerosis and thrombosis
Volume23
Issue number7
DOIs
Publication statusPublished - 01-01-2016

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Guanosine Triphosphate
Cardiovascular Diseases
Mortality
Serum
Alcohol Drinking
Coronary Disease
Stroke
Blood Pressure
Hazards
Alcohols
Aspartate Aminotransferases
Alanine Transaminase
Proportional Hazards Models
Japan
Triglycerides
Body Mass Index
Cohort Studies
Blood pressure
Smoking
Cholesterol

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

@article{57087879ac314d218e3494af8236c25e,
title = "Serum γ-glutamyltransferase and mortality due to cardiovascular disease in Japanese men and women",
abstract = "Aim: Whether the association between serum γ-glutamyltransferase (γ-GTP) levels and total cardiovascular disease (CVD) mortality is independent of alcohol drinking in East Asian populations is not well known. We conducted a pooled analysis of Japanese men and women that enabled an analysis restricted to never-drinkers. Methods: A total of 15,987 men and 25,053 women aged 40-79 years, pooled from seven cohort studies throughout Japan, were followed-up to examine sex-specific relationship between serum γ -GTP levels and total CVD mortality. Cox regression model was used that was adjusted for age, smoking status, body mass index, and systolic blood pressure and serum triglyceride, total cholesterol, aspartate aminotransferase, and alanine aminotransferase levels. Results: During an average follow-up of 8.7 years, we documented 361 and 340 deaths from total CVD, 146 and 168 from stroke, and 101 and 53 from coronary heart disease (CHD) for men and women, respectively. Among the never-drinkers, hazard ratios (HRs) for mortality for one standard deviation of log-γ-GTP for men were 1.89 (1.00-3.58) for stroke, 1.04 (0.57-1.90) for CHD, and 1.43 (1.04-1.96) for total CVD. For women, HRs were 1.28 (1.06-1.54), 1.81 (1.34-2.44), and 1.30 (1.14-1.49), respectively. Conclusion: γ-GTP may be a risk factor for total CVD mortality independent of alcohol drinking status in Japanese men and women.",
author = "{The EPOCH-JAPAN Research Group} and Enei Ri and Hiroyasu Iso and Renzhe Cui and Yoshitaka Murakami and Hiroshi Yatsuya and Katsuyuki Miura and Nagasawa, {Shin Ya} and Hirotsugu Ueshima and Tomonori Okamura and Yutaka Imai and Takayoshi Ohkubo and Fujiko Irie and Akihiko Kitamura and Yutaka Kiyohara and Hideaki Nakagawa and Takeo Nakayama and Akira Okayama and Toshimi Sairenchi and Shigeyuki Saitoh and Kiyomi Sakata and Akiko Tamakoshi and Ichiro Tsuji and Michiko Yamada and Masahiko Kiyama and Yoshihiro Miyamoto and Shizukiyo Ishikawa",
year = "2016",
month = "1",
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language = "English",
volume = "23",
pages = "792--799",
journal = "Journal of Atherosclerosis and Thrombosis",
issn = "1340-3478",
publisher = "Japan Atherosclerosis Society",
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Serum γ-glutamyltransferase and mortality due to cardiovascular disease in Japanese men and women. / The EPOCH-JAPAN Research Group.

In: Journal of atherosclerosis and thrombosis, Vol. 23, No. 7, 01.01.2016, p. 792-799.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum γ-glutamyltransferase and mortality due to cardiovascular disease in Japanese men and women

AU - The EPOCH-JAPAN Research Group

AU - Ri, Enei

AU - Iso, Hiroyasu

AU - Cui, Renzhe

AU - Murakami, Yoshitaka

AU - Yatsuya, Hiroshi

AU - Miura, Katsuyuki

AU - Nagasawa, Shin Ya

AU - Ueshima, Hirotsugu

AU - Okamura, Tomonori

AU - Imai, Yutaka

AU - Ohkubo, Takayoshi

AU - Irie, Fujiko

AU - Kitamura, Akihiko

AU - Kiyohara, Yutaka

AU - Nakagawa, Hideaki

AU - Nakayama, Takeo

AU - Okayama, Akira

AU - Sairenchi, Toshimi

AU - Saitoh, Shigeyuki

AU - Sakata, Kiyomi

AU - Tamakoshi, Akiko

AU - Tsuji, Ichiro

AU - Yamada, Michiko

AU - Kiyama, Masahiko

AU - Miyamoto, Yoshihiro

AU - Ishikawa, Shizukiyo

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Aim: Whether the association between serum γ-glutamyltransferase (γ-GTP) levels and total cardiovascular disease (CVD) mortality is independent of alcohol drinking in East Asian populations is not well known. We conducted a pooled analysis of Japanese men and women that enabled an analysis restricted to never-drinkers. Methods: A total of 15,987 men and 25,053 women aged 40-79 years, pooled from seven cohort studies throughout Japan, were followed-up to examine sex-specific relationship between serum γ -GTP levels and total CVD mortality. Cox regression model was used that was adjusted for age, smoking status, body mass index, and systolic blood pressure and serum triglyceride, total cholesterol, aspartate aminotransferase, and alanine aminotransferase levels. Results: During an average follow-up of 8.7 years, we documented 361 and 340 deaths from total CVD, 146 and 168 from stroke, and 101 and 53 from coronary heart disease (CHD) for men and women, respectively. Among the never-drinkers, hazard ratios (HRs) for mortality for one standard deviation of log-γ-GTP for men were 1.89 (1.00-3.58) for stroke, 1.04 (0.57-1.90) for CHD, and 1.43 (1.04-1.96) for total CVD. For women, HRs were 1.28 (1.06-1.54), 1.81 (1.34-2.44), and 1.30 (1.14-1.49), respectively. Conclusion: γ-GTP may be a risk factor for total CVD mortality independent of alcohol drinking status in Japanese men and women.

AB - Aim: Whether the association between serum γ-glutamyltransferase (γ-GTP) levels and total cardiovascular disease (CVD) mortality is independent of alcohol drinking in East Asian populations is not well known. We conducted a pooled analysis of Japanese men and women that enabled an analysis restricted to never-drinkers. Methods: A total of 15,987 men and 25,053 women aged 40-79 years, pooled from seven cohort studies throughout Japan, were followed-up to examine sex-specific relationship between serum γ -GTP levels and total CVD mortality. Cox regression model was used that was adjusted for age, smoking status, body mass index, and systolic blood pressure and serum triglyceride, total cholesterol, aspartate aminotransferase, and alanine aminotransferase levels. Results: During an average follow-up of 8.7 years, we documented 361 and 340 deaths from total CVD, 146 and 168 from stroke, and 101 and 53 from coronary heart disease (CHD) for men and women, respectively. Among the never-drinkers, hazard ratios (HRs) for mortality for one standard deviation of log-γ-GTP for men were 1.89 (1.00-3.58) for stroke, 1.04 (0.57-1.90) for CHD, and 1.43 (1.04-1.96) for total CVD. For women, HRs were 1.28 (1.06-1.54), 1.81 (1.34-2.44), and 1.30 (1.14-1.49), respectively. Conclusion: γ-GTP may be a risk factor for total CVD mortality independent of alcohol drinking status in Japanese men and women.

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U2 - 10.5551/jat.32698

DO - 10.5551/jat.32698

M3 - Article

C2 - 26875518

AN - SCOPUS:84976645143

VL - 23

SP - 792

EP - 799

JO - Journal of Atherosclerosis and Thrombosis

JF - Journal of Atherosclerosis and Thrombosis

SN - 1340-3478

IS - 7

ER -