Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography

Kazumi Tsubakio-Yamamoto, Taizo Sugimoto, Makoto Nishida, Rieko Okano, Yasumasa Monden, Rika Kitazume-Taneike, Taiji Yamashita, Hajime Nakaoka, Ryota Kawase, Miyako Yuasa-Kawase, Miwako Inagaki, Kazuhiro Nakatani, Daisaku Masuda, Tohru Ohama, Akifumi Matsuyama, Yumiko Nakagawa-Toyama, Masato Ishigami, Issei Komuro, Shizuya Yamashita

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver. It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism. Material/method: We investigated the correlation between serum APN concentration, HOMA-R, the lipid concentrations and lipoprotein particle size by high-performance liquid chromatography (HPLC) in 245 Japanese men during an annual health checkup. Results: Serum APN level was positively correlated with the cholesterol content in large LDL and HDL particles, but inversely correlated with the cholesterol content in large VLDL and small LDL particles. HOMA-R was negatively correlated with the cholesterol content in large LDL and HDL particles and positively correlated with the cholesterol content in large VLDL and small LDL particles. By multivariate analysis, APN was correlated with the particle size of LDL-C and HDL-C independently of age, BMI and HOMA-R. Conclusions: APN may be associated with the formation of both HDL and LDL particles, reflecting the enhancement of RCT and the improvement in TG-rich lipoprotein metabolism and insulin resistance.

Original languageEnglish
Pages (from-to)1763-1770
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume61
Issue number12
DOIs
Publication statusPublished - 01-12-2012

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Adiponectin
High Pressure Liquid Chromatography
Cholesterol
Serum
Lipoproteins
Insulin Resistance
HDL Cholesterol
Particle Size
oxidized low density lipoprotein
Liver
Apolipoproteins B
Atherosclerosis
Multivariate Analysis
Macrophages
Lipids
Health

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Tsubakio-Yamamoto, K., Sugimoto, T., Nishida, M., Okano, R., Monden, Y., Kitazume-Taneike, R., ... Yamashita, S. (2012). Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography. Metabolism: Clinical and Experimental, 61(12), 1763-1770. https://doi.org/10.1016/j.metabol.2012.05.011
Tsubakio-Yamamoto, Kazumi ; Sugimoto, Taizo ; Nishida, Makoto ; Okano, Rieko ; Monden, Yasumasa ; Kitazume-Taneike, Rika ; Yamashita, Taiji ; Nakaoka, Hajime ; Kawase, Ryota ; Yuasa-Kawase, Miyako ; Inagaki, Miwako ; Nakatani, Kazuhiro ; Masuda, Daisaku ; Ohama, Tohru ; Matsuyama, Akifumi ; Nakagawa-Toyama, Yumiko ; Ishigami, Masato ; Komuro, Issei ; Yamashita, Shizuya. / Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography. In: Metabolism: Clinical and Experimental. 2012 ; Vol. 61, No. 12. pp. 1763-1770.
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abstract = "Objective: Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver. It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism. Material/method: We investigated the correlation between serum APN concentration, HOMA-R, the lipid concentrations and lipoprotein particle size by high-performance liquid chromatography (HPLC) in 245 Japanese men during an annual health checkup. Results: Serum APN level was positively correlated with the cholesterol content in large LDL and HDL particles, but inversely correlated with the cholesterol content in large VLDL and small LDL particles. HOMA-R was negatively correlated with the cholesterol content in large LDL and HDL particles and positively correlated with the cholesterol content in large VLDL and small LDL particles. By multivariate analysis, APN was correlated with the particle size of LDL-C and HDL-C independently of age, BMI and HOMA-R. Conclusions: APN may be associated with the formation of both HDL and LDL particles, reflecting the enhancement of RCT and the improvement in TG-rich lipoprotein metabolism and insulin resistance.",
author = "Kazumi Tsubakio-Yamamoto and Taizo Sugimoto and Makoto Nishida and Rieko Okano and Yasumasa Monden and Rika Kitazume-Taneike and Taiji Yamashita and Hajime Nakaoka and Ryota Kawase and Miyako Yuasa-Kawase and Miwako Inagaki and Kazuhiro Nakatani and Daisaku Masuda and Tohru Ohama and Akifumi Matsuyama and Yumiko Nakagawa-Toyama and Masato Ishigami and Issei Komuro and Shizuya Yamashita",
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Tsubakio-Yamamoto, K, Sugimoto, T, Nishida, M, Okano, R, Monden, Y, Kitazume-Taneike, R, Yamashita, T, Nakaoka, H, Kawase, R, Yuasa-Kawase, M, Inagaki, M, Nakatani, K, Masuda, D, Ohama, T, Matsuyama, A, Nakagawa-Toyama, Y, Ishigami, M, Komuro, I & Yamashita, S 2012, 'Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography', Metabolism: Clinical and Experimental, vol. 61, no. 12, pp. 1763-1770. https://doi.org/10.1016/j.metabol.2012.05.011

Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography. / Tsubakio-Yamamoto, Kazumi; Sugimoto, Taizo; Nishida, Makoto; Okano, Rieko; Monden, Yasumasa; Kitazume-Taneike, Rika; Yamashita, Taiji; Nakaoka, Hajime; Kawase, Ryota; Yuasa-Kawase, Miyako; Inagaki, Miwako; Nakatani, Kazuhiro; Masuda, Daisaku; Ohama, Tohru; Matsuyama, Akifumi; Nakagawa-Toyama, Yumiko; Ishigami, Masato; Komuro, Issei; Yamashita, Shizuya.

In: Metabolism: Clinical and Experimental, Vol. 61, No. 12, 01.12.2012, p. 1763-1770.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography

AU - Tsubakio-Yamamoto, Kazumi

AU - Sugimoto, Taizo

AU - Nishida, Makoto

AU - Okano, Rieko

AU - Monden, Yasumasa

AU - Kitazume-Taneike, Rika

AU - Yamashita, Taiji

AU - Nakaoka, Hajime

AU - Kawase, Ryota

AU - Yuasa-Kawase, Miyako

AU - Inagaki, Miwako

AU - Nakatani, Kazuhiro

AU - Masuda, Daisaku

AU - Ohama, Tohru

AU - Matsuyama, Akifumi

AU - Nakagawa-Toyama, Yumiko

AU - Ishigami, Masato

AU - Komuro, Issei

AU - Yamashita, Shizuya

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Objective: Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver. It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism. Material/method: We investigated the correlation between serum APN concentration, HOMA-R, the lipid concentrations and lipoprotein particle size by high-performance liquid chromatography (HPLC) in 245 Japanese men during an annual health checkup. Results: Serum APN level was positively correlated with the cholesterol content in large LDL and HDL particles, but inversely correlated with the cholesterol content in large VLDL and small LDL particles. HOMA-R was negatively correlated with the cholesterol content in large LDL and HDL particles and positively correlated with the cholesterol content in large VLDL and small LDL particles. By multivariate analysis, APN was correlated with the particle size of LDL-C and HDL-C independently of age, BMI and HOMA-R. Conclusions: APN may be associated with the formation of both HDL and LDL particles, reflecting the enhancement of RCT and the improvement in TG-rich lipoprotein metabolism and insulin resistance.

AB - Objective: Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver. It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism. Material/method: We investigated the correlation between serum APN concentration, HOMA-R, the lipid concentrations and lipoprotein particle size by high-performance liquid chromatography (HPLC) in 245 Japanese men during an annual health checkup. Results: Serum APN level was positively correlated with the cholesterol content in large LDL and HDL particles, but inversely correlated with the cholesterol content in large VLDL and small LDL particles. HOMA-R was negatively correlated with the cholesterol content in large LDL and HDL particles and positively correlated with the cholesterol content in large VLDL and small LDL particles. By multivariate analysis, APN was correlated with the particle size of LDL-C and HDL-C independently of age, BMI and HOMA-R. Conclusions: APN may be associated with the formation of both HDL and LDL particles, reflecting the enhancement of RCT and the improvement in TG-rich lipoprotein metabolism and insulin resistance.

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