Serum albumin-adjusted glycated albumin is a better predictor of mortality in diabetic patients with end-stage renal disease on hemodialysis

Takahiro Yajima, Kumiko Yajima, Makoto Hayashi, Keigo Yasuda, Hiroshi Takahashi, Noriyoshi Yamakita

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aims Glycated albumin (GA) is a marker for monitoring glycemic control in diabetic patients with end-stage renal disease (ESRD). We evaluated whether serum albumin-adjusted GA (adjusted GA) could predict mortality in diabetic patients with ESRD on hemodialysis. Methods Seventy-eight patients with type 2 diabetes treated with regular hemodialysis were enrolled and followed up for 5-years. The adjusted GA was calculated from the regression formula and mean GA. The cut-off values for GA and adjusted GA that predicted mortality risk were determined using receiver operating characteristic curve analysis. Results During the follow-up period (median: 36 months), 15 patients died. In the Kaplan-Meier analysis, there were no significant differences in the 5-year cumulative survival rate (58.3% [GA ≥ 19.8%] vs. 88.6% [GA < 19.8%], P = 0.075). Conversely, this rate was significantly higher in patients with adjusted GA < 21.2% than adjusted GA ≥ 21.2% (86.4 vs. 49.5%, P = 0.0068). After adjustment for other confounders, adjusted GA ≥ 21.2% was an independent predictor for mortality (hazard ratio 3.76, 95% confidence interval 1.12-17.44, P = 0.031), but GA ≥ 19.8% was not (hazard ratio 2.63, 95% confidence interval 0.65-17.69, P = 0.19). Conclusions Adjusted GA is a better predictor of mortality than GA in diabetic patients with ESRD on hemodialysis.

Original languageEnglish
Pages (from-to)786-789
Number of pages4
JournalJournal of Diabetes and its Complications
Volume30
Issue number5
DOIs
Publication statusPublished - 01-07-2016

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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