TY - JOUR
T1 - Serum angiopoietin-like protein 2 improves preoperative detection of lymph node metastasis in colorectal cancer
AU - Toiyama, Yuji
AU - Inoue, Yasuhiro
AU - Shimura, Tadanobu
AU - Fujikawa, Hiroyuki
AU - Saigusa, Susumu
AU - Hiro, Jyunichiro
AU - Kobayashi, Minako
AU - Ohi, Masaki
AU - Araki, Toshimitsu
AU - Tanaka, Koji
AU - Mohri, Yasuhiko
AU - Kusunoki, Masato
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Aim: We investigated whether serum markers and clinical factors could be used to preoperatively predict lymph node (LN) metastasis in colorectal cancer (CRC). Patients and Methods: The present study enrolled 157 curative CRC patients for whom preoperative serum carcinoembryonic antigen (CEA), systemic inflammatory markers (C-reactive protein (CRP) and angiopoietin-like protein 2 (ANGPTL2)) and objective preoperative clinical factors were available as indicators of pathological LN status. Results: Specific clinical factors, including gender, tumor size, histopathology of biopsy sample and tumor morphology, were significantly correlated with LN metastases. Additionally, CEA, CRP and ANGPTL2 levels were also predictive factors for LN status. Multivariate analysis revealed that clinical factors, including gender, histopathology, tumor morphology and ANGPTL2, were identified as independent predictive factors for LN metastases. A combination of clinical factors reached high predictive accuracy of LN metastases and, combined with clinical factors, ANGPTL2 further improved the accuracy. Conclusion: Serum ANGPTL2 improves preoperative detection of LN metastasis in CRC.
AB - Aim: We investigated whether serum markers and clinical factors could be used to preoperatively predict lymph node (LN) metastasis in colorectal cancer (CRC). Patients and Methods: The present study enrolled 157 curative CRC patients for whom preoperative serum carcinoembryonic antigen (CEA), systemic inflammatory markers (C-reactive protein (CRP) and angiopoietin-like protein 2 (ANGPTL2)) and objective preoperative clinical factors were available as indicators of pathological LN status. Results: Specific clinical factors, including gender, tumor size, histopathology of biopsy sample and tumor morphology, were significantly correlated with LN metastases. Additionally, CEA, CRP and ANGPTL2 levels were also predictive factors for LN status. Multivariate analysis revealed that clinical factors, including gender, histopathology, tumor morphology and ANGPTL2, were identified as independent predictive factors for LN metastases. A combination of clinical factors reached high predictive accuracy of LN metastases and, combined with clinical factors, ANGPTL2 further improved the accuracy. Conclusion: Serum ANGPTL2 improves preoperative detection of LN metastasis in CRC.
KW - ANGPTL2
KW - C-reactive protein
KW - CEA
KW - Colorectal cancer
KW - Lymph node metastasis
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M3 - Article
C2 - 25964566
AN - SCOPUS:84929674357
SN - 0250-7005
VL - 35
SP - 2849
EP - 2856
JO - Anticancer research
JF - Anticancer research
IS - 5
ER -