Serum brain-derived neurotrophic factor, and plasma catecholamine metabolites in people with major depression

Preliminary cross-sectional study

Reiji Yoshimura, Taro Kishi, Kiyokazu Atake, Asuka Katsuki, Nakao Iwata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: There are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood. Objective: This paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD). Materials and methods: A total of 148 patients (male/female 65/83, age 49.5 ± 12.1 years old) who satisfied criteria for MD based on the Diagnostic and Statistical Manual of Mental Disorders IV were enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using high-performance liquid chromatography, and serum BDNF was measured using ELISA. Results: No interactions were observed between plasma HVA levels (mean ± SD = 4.5 ± 1.5 ng/mL) and age, sex, HAMD scores, or serum BDNF levels (mean ± SD = 9.8 ± 2.9 ng/mL). No correlations were not also observed between plasma MHPG levels (mean ± SD = 5.9 ± 2.1 ng/mL) and age, sex, the HAMD17 scores (mean ± SD = 22.2 ± 2.9 ng/mL), or serum BDNF levels. Serum BDNF levels were negatively associated with HAMD17 scores. Conclusion: The results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients.

Original languageEnglish
Article number52
JournalFrontiers in Psychiatry
Volume9
Issue numberFEB
DOIs
Publication statusPublished - 28-02-2018

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Brain-Derived Neurotrophic Factor
Catecholamines
Cross-Sectional Studies
Homovanillic Acid
Serum
Diagnostic and Statistical Manual of Mental Disorders
Enzyme-Linked Immunosorbent Assay
High Pressure Liquid Chromatography
Neurons
4-hydroxyphenethylene glycol
Brain

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

@article{71e8e854257e473c9c3e296b69c2fecf,
title = "Serum brain-derived neurotrophic factor, and plasma catecholamine metabolites in people with major depression: Preliminary cross-sectional study",
abstract = "Background: There are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood. Objective: This paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD). Materials and methods: A total of 148 patients (male/female 65/83, age 49.5 ± 12.1 years old) who satisfied criteria for MD based on the Diagnostic and Statistical Manual of Mental Disorders IV were enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using high-performance liquid chromatography, and serum BDNF was measured using ELISA. Results: No interactions were observed between plasma HVA levels (mean ± SD = 4.5 ± 1.5 ng/mL) and age, sex, HAMD scores, or serum BDNF levels (mean ± SD = 9.8 ± 2.9 ng/mL). No correlations were not also observed between plasma MHPG levels (mean ± SD = 5.9 ± 2.1 ng/mL) and age, sex, the HAMD17 scores (mean ± SD = 22.2 ± 2.9 ng/mL), or serum BDNF levels. Serum BDNF levels were negatively associated with HAMD17 scores. Conclusion: The results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients.",
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Serum brain-derived neurotrophic factor, and plasma catecholamine metabolites in people with major depression : Preliminary cross-sectional study. / Yoshimura, Reiji; Kishi, Taro; Atake, Kiyokazu; Katsuki, Asuka; Iwata, Nakao.

In: Frontiers in Psychiatry, Vol. 9, No. FEB, 52, 28.02.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum brain-derived neurotrophic factor, and plasma catecholamine metabolites in people with major depression

T2 - Preliminary cross-sectional study

AU - Yoshimura, Reiji

AU - Kishi, Taro

AU - Atake, Kiyokazu

AU - Katsuki, Asuka

AU - Iwata, Nakao

PY - 2018/2/28

Y1 - 2018/2/28

N2 - Background: There are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood. Objective: This paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD). Materials and methods: A total of 148 patients (male/female 65/83, age 49.5 ± 12.1 years old) who satisfied criteria for MD based on the Diagnostic and Statistical Manual of Mental Disorders IV were enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using high-performance liquid chromatography, and serum BDNF was measured using ELISA. Results: No interactions were observed between plasma HVA levels (mean ± SD = 4.5 ± 1.5 ng/mL) and age, sex, HAMD scores, or serum BDNF levels (mean ± SD = 9.8 ± 2.9 ng/mL). No correlations were not also observed between plasma MHPG levels (mean ± SD = 5.9 ± 2.1 ng/mL) and age, sex, the HAMD17 scores (mean ± SD = 22.2 ± 2.9 ng/mL), or serum BDNF levels. Serum BDNF levels were negatively associated with HAMD17 scores. Conclusion: The results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients.

AB - Background: There are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood. Objective: This paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD). Materials and methods: A total of 148 patients (male/female 65/83, age 49.5 ± 12.1 years old) who satisfied criteria for MD based on the Diagnostic and Statistical Manual of Mental Disorders IV were enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using high-performance liquid chromatography, and serum BDNF was measured using ELISA. Results: No interactions were observed between plasma HVA levels (mean ± SD = 4.5 ± 1.5 ng/mL) and age, sex, HAMD scores, or serum BDNF levels (mean ± SD = 9.8 ± 2.9 ng/mL). No correlations were not also observed between plasma MHPG levels (mean ± SD = 5.9 ± 2.1 ng/mL) and age, sex, the HAMD17 scores (mean ± SD = 22.2 ± 2.9 ng/mL), or serum BDNF levels. Serum BDNF levels were negatively associated with HAMD17 scores. Conclusion: The results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients.

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DO - 10.3389/fpsyt.2018.00052

M3 - Article

VL - 9

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

SN - 1664-0640

IS - FEB

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