Serum Brain Natriuretic Peptide Concentration 60 Days after Surgery as a Predictor of Long-Term Prognosis in Patients Implanted with a Left Ventricular Assist Device

Takuma Sato, Osamu Seguchi, Yoshio Iwashima, Masanobu Yanase, Seiko Nakajima, Michinari Hieda, Takuya Watanabe, Haruki Sunami, Yoshihiro Murata, Hiroki Hata, Tomoyuki Fujita, Junjiro Kobayashi, Takeshi Nakatani

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Mechanical circulatory support by a left ventricular assist device (LVAD) is used to bridge patients with advanced heart failure to transplant or as a definitive treatment. We retrospectively sought predictors of long-term outcome in a cohort of 83 patients who had undergone LVAD treatment. We subjected perioperative clinical data of patients to statistical analysis to establish parameters associated with all-cause mortality, and the cutoff values, sensitivity, and specificity of those that had a statistically significant relation with survival. Mean follow-up was 717 days (standard deviation, 334 days; range, 17-1,592 days). Fourteen patients (16.8%) died, but nine (10.8%) were weaned from support. Serum brain natriuretic peptide (BNP) concentration measured 60 days after implantation was significantly associated with all-cause mortality. The optimal BNP cutoff value to predict death during LVAD support was 322 pg/ml, with a sensitivity of 71.4% and specificity of 79.8%. Two-year survival was 92.0% in those with 60 days serum BNP concentration <322 pg/ml compared with 70.5% in those in whom it was ≥322 pg/ml (p = 0.003). The relation between BNP and survival likely reflects recovery of native myocardial function and improvements in global health and should assist clinicians in the on-going management of long-term LVAD therapy.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalASAIO Journal
Volume61
Issue number4
DOIs
Publication statusPublished - 21-07-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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