Serum carotenoids and mortality from lung cancer

A case-control study nested in the Japan Collaborative Cohort (JACC) Study

Yoshinori Ito, Kenji Wakai, Koji Suzuki, Akiko Tamakoshi, Nao Seki, Masahiko Ando, Yoshikazu Nishino, Takaaki Kondo, Yoshiyuki Watanabe, Kotaro Ozasa, Yoshiyuki Ohno, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Shuji Hashimoto, Yutaka Inaba, Yoshiharu Hoshiyama & 27 others Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Shinkan Tokudome, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Katsuhiro Fukuda, Naoyuki Okamoto, Hideo Shio, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima, Kei Nakachi, Takashi Shimamoto, Heizo Tanaka, Shigeru Hisamichi, Masahiro Nakao, Takaichiro Suzuki, Tsutomu Hashimoto, Teruo Ishibashi

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

To investigate whether high serum levels of carotenoids, tocopherols, and folic acid decrease risk of lung cancer in Japanese, we conducted a case-control study nested in the Japan Collaborative Cohort (JACC) Study. A total of 39 140 subjects provided serum samples at baseline between 1988 and 1990. We identified 147 cases (113 males and 34 females) of death from lung cancer during an 8-year follow-up. Of the subjects who survived to the end of this follow-up, 311 controls (237 males and 74 females) were selected, matched to each case of lung cancer death for gender, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratios (ORs) for lung cancer death were estimated using conditional logistic models. The risk of lung cancer death for the highest quartile of serum α-carotene, β-carotene, lycopene, β-cryptoxanthin, and canthaxanthin was significantly or marginally significantly lower than for the lowest quartile: the ORs, adjusted for smoking and other covariates, were 0.35 (95% confidence interval (Cl), 0.14-0.88), 0.21 (0.08-0.58), 0.46 (0.21-1.04), 0.44 (0.17-1.16) and 0.37 (0.15-0.91), respectively. The ORs for the highest serum levels of zeaxanthin/lutein and folic acid tended to be low, but the differences were not statistically significant. Serum total cholesterol was also inversely related to risk of lung cancer death: the OR for the highest vs. the lowest quartile was 0.39 (95% Cl, 0.19-0.79). Higher serum levels of carotenoids such as α- and β-carotenes may play a role in preventing death from lung cancer among Japanese.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalCancer Science
Volume94
Issue number1
DOIs
Publication statusPublished - 01-01-2003

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Carotenoids
Case-Control Studies
Lung Neoplasms
Japan
Cohort Studies
Mortality
Serum
Odds Ratio
Folic Acid
Canthaxanthin
Lutein
Tocopherols
Antioxidants
Logistic Models
Smoking
Cholesterol
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ito, Yoshinori ; Wakai, Kenji ; Suzuki, Koji ; Tamakoshi, Akiko ; Seki, Nao ; Ando, Masahiko ; Nishino, Yoshikazu ; Kondo, Takaaki ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Ohno, Yoshiyuki ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Hashimoto, Shuji ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Toyoshima, Hideaki ; Tokudome, Shinkan ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Fukuda, Katsuhiro ; Okamoto, Naoyuki ; Shio, Hideo ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo ; Nakachi, Kei ; Shimamoto, Takashi ; Tanaka, Heizo ; Hisamichi, Shigeru ; Nakao, Masahiro ; Suzuki, Takaichiro ; Hashimoto, Tsutomu ; Ishibashi, Teruo. / Serum carotenoids and mortality from lung cancer : A case-control study nested in the Japan Collaborative Cohort (JACC) Study. In: Cancer Science. 2003 ; Vol. 94, No. 1. pp. 57-63.
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abstract = "To investigate whether high serum levels of carotenoids, tocopherols, and folic acid decrease risk of lung cancer in Japanese, we conducted a case-control study nested in the Japan Collaborative Cohort (JACC) Study. A total of 39 140 subjects provided serum samples at baseline between 1988 and 1990. We identified 147 cases (113 males and 34 females) of death from lung cancer during an 8-year follow-up. Of the subjects who survived to the end of this follow-up, 311 controls (237 males and 74 females) were selected, matched to each case of lung cancer death for gender, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratios (ORs) for lung cancer death were estimated using conditional logistic models. The risk of lung cancer death for the highest quartile of serum α-carotene, β-carotene, lycopene, β-cryptoxanthin, and canthaxanthin was significantly or marginally significantly lower than for the lowest quartile: the ORs, adjusted for smoking and other covariates, were 0.35 (95{\%} confidence interval (Cl), 0.14-0.88), 0.21 (0.08-0.58), 0.46 (0.21-1.04), 0.44 (0.17-1.16) and 0.37 (0.15-0.91), respectively. The ORs for the highest serum levels of zeaxanthin/lutein and folic acid tended to be low, but the differences were not statistically significant. Serum total cholesterol was also inversely related to risk of lung cancer death: the OR for the highest vs. the lowest quartile was 0.39 (95{\%} Cl, 0.19-0.79). Higher serum levels of carotenoids such as α- and β-carotenes may play a role in preventing death from lung cancer among Japanese.",
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Ito, Y, Wakai, K, Suzuki, K, Tamakoshi, A, Seki, N, Ando, M, Nishino, Y, Kondo, T, Watanabe, Y, Ozasa, K, Ohno, Y, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Hashimoto, S, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Toyoshima, H, Tokudome, S, Kikuchi, S, Koizumi, A, Kawamura, T, Miki, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Fukuda, K, Okamoto, N, Shio, H, Kitagawa, T, Kuroki, T, Tajima, K, Nakachi, K, Shimamoto, T, Tanaka, H, Hisamichi, S, Nakao, M, Suzuki, T, Hashimoto, T & Ishibashi, T 2003, 'Serum carotenoids and mortality from lung cancer: A case-control study nested in the Japan Collaborative Cohort (JACC) Study', Cancer Science, vol. 94, no. 1, pp. 57-63. https://doi.org/10.1111/j.1349-7006.2003.tb01352.x

Serum carotenoids and mortality from lung cancer : A case-control study nested in the Japan Collaborative Cohort (JACC) Study. / Ito, Yoshinori; Wakai, Kenji; Suzuki, Koji; Tamakoshi, Akiko; Seki, Nao; Ando, Masahiko; Nishino, Yoshikazu; Kondo, Takaaki; Watanabe, Yoshiyuki; Ozasa, Kotaro; Ohno, Yoshiyuki; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Hashimoto, Shuji; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Toyoshima, Hideaki; Tokudome, Shinkan; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Fukuda, Katsuhiro; Okamoto, Naoyuki; Shio, Hideo; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo; Nakachi, Kei; Shimamoto, Takashi; Tanaka, Heizo; Hisamichi, Shigeru; Nakao, Masahiro; Suzuki, Takaichiro; Hashimoto, Tsutomu; Ishibashi, Teruo.

In: Cancer Science, Vol. 94, No. 1, 01.01.2003, p. 57-63.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Serum carotenoids and mortality from lung cancer

T2 - A case-control study nested in the Japan Collaborative Cohort (JACC) Study

AU - Ito, Yoshinori

AU - Wakai, Kenji

AU - Suzuki, Koji

AU - Tamakoshi, Akiko

AU - Seki, Nao

AU - Ando, Masahiko

AU - Nishino, Yoshikazu

AU - Kondo, Takaaki

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Ohno, Yoshiyuki

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Hashimoto, Shuji

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Toyoshima, Hideaki

AU - Tokudome, Shinkan

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Fukuda, Katsuhiro

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

AU - Nakachi, Kei

AU - Shimamoto, Takashi

AU - Tanaka, Heizo

AU - Hisamichi, Shigeru

AU - Nakao, Masahiro

AU - Suzuki, Takaichiro

AU - Hashimoto, Tsutomu

AU - Ishibashi, Teruo

PY - 2003/1/1

Y1 - 2003/1/1

N2 - To investigate whether high serum levels of carotenoids, tocopherols, and folic acid decrease risk of lung cancer in Japanese, we conducted a case-control study nested in the Japan Collaborative Cohort (JACC) Study. A total of 39 140 subjects provided serum samples at baseline between 1988 and 1990. We identified 147 cases (113 males and 34 females) of death from lung cancer during an 8-year follow-up. Of the subjects who survived to the end of this follow-up, 311 controls (237 males and 74 females) were selected, matched to each case of lung cancer death for gender, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratios (ORs) for lung cancer death were estimated using conditional logistic models. The risk of lung cancer death for the highest quartile of serum α-carotene, β-carotene, lycopene, β-cryptoxanthin, and canthaxanthin was significantly or marginally significantly lower than for the lowest quartile: the ORs, adjusted for smoking and other covariates, were 0.35 (95% confidence interval (Cl), 0.14-0.88), 0.21 (0.08-0.58), 0.46 (0.21-1.04), 0.44 (0.17-1.16) and 0.37 (0.15-0.91), respectively. The ORs for the highest serum levels of zeaxanthin/lutein and folic acid tended to be low, but the differences were not statistically significant. Serum total cholesterol was also inversely related to risk of lung cancer death: the OR for the highest vs. the lowest quartile was 0.39 (95% Cl, 0.19-0.79). Higher serum levels of carotenoids such as α- and β-carotenes may play a role in preventing death from lung cancer among Japanese.

AB - To investigate whether high serum levels of carotenoids, tocopherols, and folic acid decrease risk of lung cancer in Japanese, we conducted a case-control study nested in the Japan Collaborative Cohort (JACC) Study. A total of 39 140 subjects provided serum samples at baseline between 1988 and 1990. We identified 147 cases (113 males and 34 females) of death from lung cancer during an 8-year follow-up. Of the subjects who survived to the end of this follow-up, 311 controls (237 males and 74 females) were selected, matched to each case of lung cancer death for gender, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratios (ORs) for lung cancer death were estimated using conditional logistic models. The risk of lung cancer death for the highest quartile of serum α-carotene, β-carotene, lycopene, β-cryptoxanthin, and canthaxanthin was significantly or marginally significantly lower than for the lowest quartile: the ORs, adjusted for smoking and other covariates, were 0.35 (95% confidence interval (Cl), 0.14-0.88), 0.21 (0.08-0.58), 0.46 (0.21-1.04), 0.44 (0.17-1.16) and 0.37 (0.15-0.91), respectively. The ORs for the highest serum levels of zeaxanthin/lutein and folic acid tended to be low, but the differences were not statistically significant. Serum total cholesterol was also inversely related to risk of lung cancer death: the OR for the highest vs. the lowest quartile was 0.39 (95% Cl, 0.19-0.79). Higher serum levels of carotenoids such as α- and β-carotenes may play a role in preventing death from lung cancer among Japanese.

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DO - 10.1111/j.1349-7006.2003.tb01352.x

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SP - 57

EP - 63

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

IS - 1

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