Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: Effect modification by sex for carotenoids

Kenji Wakai, Koji Suzuki, Yoshinori Ito, Masayo Kojima, Koji Tamakoshi, Yoshiyuki Watanabe, Hideaki Toyoshima, Norihiko Hayakawa, Shuji Hashimoto, Shinkan Tokudome, Sadao Suzuki, Miyuki Kawado, Kotaro Ozasa

Research output: Contribution to journalArticle

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Abstract

To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study. These micronutrients were measured in prediagnostic sérum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls. In men, the higher level of serum total carotenoids was associated with a decreased risk: The multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile was 0.34 (95% confidence interval [CI] = 0.11-1.00; trend P over tertiles = 0.040). In women, the higher levels of α- and β-carotenes and total carotenoids were instead related to an increased risk: The corresponding ORs were 4.72 (95% CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively (trend P = 0.007, 0.040, and 0.064, respectively). We also found a somewhat decreasing risk with increased serum retinal in all subjects and α-tocopherol in men: The ORs (95% CI) for the highest tertiles were 0.29 (0.11-0.78; trend P over tertiles = 0.010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits.

Original languageEnglish
Pages (from-to)13-24
Number of pages12
JournalNutrition and Cancer
Volume51
Issue number1
DOIs
Publication statusPublished - 29-03-2005

Fingerprint

Cohort Effect
Tocopherols
Carotenoids
Vitamin A
Colorectal Neoplasms
Serum
Confidence Intervals
Sex Factors
Micronutrients
Drinking
Habits
Case-Control Studies
Japan
Cohort Studies
Smoking
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Wakai, Kenji ; Suzuki, Koji ; Ito, Yoshinori ; Kojima, Masayo ; Tamakoshi, Koji ; Watanabe, Yoshiyuki ; Toyoshima, Hideaki ; Hayakawa, Norihiko ; Hashimoto, Shuji ; Tokudome, Shinkan ; Suzuki, Sadao ; Kawado, Miyuki ; Ozasa, Kotaro. / Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort : Effect modification by sex for carotenoids. In: Nutrition and Cancer. 2005 ; Vol. 51, No. 1. pp. 13-24.
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abstract = "To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study. These micronutrients were measured in prediagnostic s{\'e}rum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls. In men, the higher level of serum total carotenoids was associated with a decreased risk: The multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile was 0.34 (95{\%} confidence interval [CI] = 0.11-1.00; trend P over tertiles = 0.040). In women, the higher levels of α- and β-carotenes and total carotenoids were instead related to an increased risk: The corresponding ORs were 4.72 (95{\%} CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively (trend P = 0.007, 0.040, and 0.064, respectively). We also found a somewhat decreasing risk with increased serum retinal in all subjects and α-tocopherol in men: The ORs (95{\%} CI) for the highest tertiles were 0.29 (0.11-0.78; trend P over tertiles = 0.010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits.",
author = "Kenji Wakai and Koji Suzuki and Yoshinori Ito and Masayo Kojima and Koji Tamakoshi and Yoshiyuki Watanabe and Hideaki Toyoshima and Norihiko Hayakawa and Shuji Hashimoto and Shinkan Tokudome and Sadao Suzuki and Miyuki Kawado and Kotaro Ozasa",
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Wakai, K, Suzuki, K, Ito, Y, Kojima, M, Tamakoshi, K, Watanabe, Y, Toyoshima, H, Hayakawa, N, Hashimoto, S, Tokudome, S, Suzuki, S, Kawado, M & Ozasa, K 2005, 'Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: Effect modification by sex for carotenoids', Nutrition and Cancer, vol. 51, no. 1, pp. 13-24. https://doi.org/10.1207/s15327914nc5101_3

Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort : Effect modification by sex for carotenoids. / Wakai, Kenji; Suzuki, Koji; Ito, Yoshinori; Kojima, Masayo; Tamakoshi, Koji; Watanabe, Yoshiyuki; Toyoshima, Hideaki; Hayakawa, Norihiko; Hashimoto, Shuji; Tokudome, Shinkan; Suzuki, Sadao; Kawado, Miyuki; Ozasa, Kotaro.

In: Nutrition and Cancer, Vol. 51, No. 1, 29.03.2005, p. 13-24.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort

T2 - Effect modification by sex for carotenoids

AU - Wakai, Kenji

AU - Suzuki, Koji

AU - Ito, Yoshinori

AU - Kojima, Masayo

AU - Tamakoshi, Koji

AU - Watanabe, Yoshiyuki

AU - Toyoshima, Hideaki

AU - Hayakawa, Norihiko

AU - Hashimoto, Shuji

AU - Tokudome, Shinkan

AU - Suzuki, Sadao

AU - Kawado, Miyuki

AU - Ozasa, Kotaro

PY - 2005/3/29

Y1 - 2005/3/29

N2 - To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study. These micronutrients were measured in prediagnostic sérum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls. In men, the higher level of serum total carotenoids was associated with a decreased risk: The multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile was 0.34 (95% confidence interval [CI] = 0.11-1.00; trend P over tertiles = 0.040). In women, the higher levels of α- and β-carotenes and total carotenoids were instead related to an increased risk: The corresponding ORs were 4.72 (95% CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively (trend P = 0.007, 0.040, and 0.064, respectively). We also found a somewhat decreasing risk with increased serum retinal in all subjects and α-tocopherol in men: The ORs (95% CI) for the highest tertiles were 0.29 (0.11-0.78; trend P over tertiles = 0.010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits.

AB - To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study. These micronutrients were measured in prediagnostic sérum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls. In men, the higher level of serum total carotenoids was associated with a decreased risk: The multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile was 0.34 (95% confidence interval [CI] = 0.11-1.00; trend P over tertiles = 0.040). In women, the higher levels of α- and β-carotenes and total carotenoids were instead related to an increased risk: The corresponding ORs were 4.72 (95% CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively (trend P = 0.007, 0.040, and 0.064, respectively). We also found a somewhat decreasing risk with increased serum retinal in all subjects and α-tocopherol in men: The ORs (95% CI) for the highest tertiles were 0.29 (0.11-0.78; trend P over tertiles = 0.010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits.

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