Abstract
To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study. These micronutrients were measured in prediagnostic sérum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls. In men, the higher level of serum total carotenoids was associated with a decreased risk: The multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile was 0.34 (95% confidence interval [CI] = 0.11-1.00; trend P over tertiles = 0.040). In women, the higher levels of α- and β-carotenes and total carotenoids were instead related to an increased risk: The corresponding ORs were 4.72 (95% CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively (trend P = 0.007, 0.040, and 0.064, respectively). We also found a somewhat decreasing risk with increased serum retinal in all subjects and α-tocopherol in men: The ORs (95% CI) for the highest tertiles were 0.29 (0.11-0.78; trend P over tertiles = 0.010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits.
| Original language | English |
|---|---|
| Pages (from-to) | 13-24 |
| Number of pages | 12 |
| Journal | Nutrition and Cancer |
| Volume | 51 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 29-03-2005 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Oncology
- Nutrition and Dietetics
- Cancer Research
Cite this
}
Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort : Effect modification by sex for carotenoids. / Wakai, Kenji; Suzuki, Koji; Ito, Yoshinori; Kojima, Masayo; Tamakoshi, Koji; Watanabe, Yoshiyuki; Toyoshima, Hideaki; Hayakawa, Norihiko; Hashimoto, Shuji; Tokudome, Shinkan; Suzuki, Sadao; Kawado, Miyuki; Ozasa, Kotaro.
In: Nutrition and Cancer, Vol. 51, No. 1, 29.03.2005, p. 13-24.Research output: Contribution to journal › Article
TY - JOUR
T1 - Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort
T2 - Effect modification by sex for carotenoids
AU - Wakai, Kenji
AU - Suzuki, Koji
AU - Ito, Yoshinori
AU - Kojima, Masayo
AU - Tamakoshi, Koji
AU - Watanabe, Yoshiyuki
AU - Toyoshima, Hideaki
AU - Hayakawa, Norihiko
AU - Hashimoto, Shuji
AU - Tokudome, Shinkan
AU - Suzuki, Sadao
AU - Kawado, Miyuki
AU - Ozasa, Kotaro
PY - 2005/3/29
Y1 - 2005/3/29
N2 - To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study. These micronutrients were measured in prediagnostic sérum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls. In men, the higher level of serum total carotenoids was associated with a decreased risk: The multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile was 0.34 (95% confidence interval [CI] = 0.11-1.00; trend P over tertiles = 0.040). In women, the higher levels of α- and β-carotenes and total carotenoids were instead related to an increased risk: The corresponding ORs were 4.72 (95% CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively (trend P = 0.007, 0.040, and 0.064, respectively). We also found a somewhat decreasing risk with increased serum retinal in all subjects and α-tocopherol in men: The ORs (95% CI) for the highest tertiles were 0.29 (0.11-0.78; trend P over tertiles = 0.010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits.
AB - To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study. These micronutrients were measured in prediagnostic sérum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls. In men, the higher level of serum total carotenoids was associated with a decreased risk: The multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile was 0.34 (95% confidence interval [CI] = 0.11-1.00; trend P over tertiles = 0.040). In women, the higher levels of α- and β-carotenes and total carotenoids were instead related to an increased risk: The corresponding ORs were 4.72 (95% CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively (trend P = 0.007, 0.040, and 0.064, respectively). We also found a somewhat decreasing risk with increased serum retinal in all subjects and α-tocopherol in men: The ORs (95% CI) for the highest tertiles were 0.29 (0.11-0.78; trend P over tertiles = 0.010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits.
UR - http://www.scopus.com/inward/record.url?scp=20144367602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20144367602&partnerID=8YFLogxK
U2 - 10.1207/s15327914nc5101_3
DO - 10.1207/s15327914nc5101_3
M3 - Article
C2 - 15749625
AN - SCOPUS:20144367602
VL - 51
SP - 13
EP - 24
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 1
ER -