Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus

Iwase Okadaa Kimi, Nagatsua Toshiharu, Fujita Keisuke, Torikai Katsutaka, Hamamoto Tatsuo, Shibata Tsunehiro, Maeno Yoshimasa, Sakakibara Shumpei

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Abstract

Collagenase-like(CL) peptidase activity in serum, which was measured using a newly synthesized substrate, (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide, was significantly lower in patients with advanced rheumatoid arthritis or with systemic lupus erythematosus than that in normal controls. Decrease of the serum enzyme activity was more pronounced in systemic lupus erythematosus. No significant change in serum CL-peptidase activity was found in other connective tissue diseases such as mixed connective tissue disease and Sjogren's syndrome.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalClinica Chimica Acta
Volume146
Issue number1
DOIs
Publication statusPublished - 28-02-1985

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kimi, I. O., Toshiharu, N., Keisuke, F., Katsutaka, T., Tatsuo, H., Tsunehiro, S., Yoshimasa, M., & Shumpei, S. (1985). Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus. Clinica Chimica Acta, 146(1), 75-79. https://doi.org/10.1016/0009-8981(85)90125-1