TY - JOUR
T1 - Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus
AU - Kimi, Iwase Okadaa
AU - Toshiharu, Nagatsua
AU - Keisuke, Fujita
AU - Katsutaka, Torikai
AU - Tatsuo, Hamamoto
AU - Tsunehiro, Shibata
AU - Yoshimasa, Maeno
AU - Shumpei, Sakakibara
PY - 1985/2/28
Y1 - 1985/2/28
N2 - Collagenase-like(CL) peptidase activity in serum, which was measured using a newly synthesized substrate, (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide, was significantly lower in patients with advanced rheumatoid arthritis or with systemic lupus erythematosus than that in normal controls. Decrease of the serum enzyme activity was more pronounced in systemic lupus erythematosus. No significant change in serum CL-peptidase activity was found in other connective tissue diseases such as mixed connective tissue disease and Sjogren's syndrome.
AB - Collagenase-like(CL) peptidase activity in serum, which was measured using a newly synthesized substrate, (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide, was significantly lower in patients with advanced rheumatoid arthritis or with systemic lupus erythematosus than that in normal controls. Decrease of the serum enzyme activity was more pronounced in systemic lupus erythematosus. No significant change in serum CL-peptidase activity was found in other connective tissue diseases such as mixed connective tissue disease and Sjogren's syndrome.
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U2 - 10.1016/0009-8981(85)90125-1
DO - 10.1016/0009-8981(85)90125-1
M3 - Article
C2 - 2985298
AN - SCOPUS:0021880773
VL - 146
SP - 75
EP - 79
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 1
ER -