Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus

Iwase Okadaa Kimi; Nagatsua Toshiharu; Fujita Keisuke; Torikai Katsutaka; Hamamoto Tatsuo; Shibata Tsunehiro; Maeno Yoshimasa; Sakakibara Shumpei

doi:10.1016/0009-8981(85)90125-1

Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus

Iwase Okadaa Kimi, Nagatsua Toshiharu, Fujita Keisuke, Torikai Katsutaka, Hamamoto Tatsuo, Shibata Tsunehiro, Maeno Yoshimasa, Sakakibara Shumpei

Department of Virology and Parasitology

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Collagenase-like(CL) peptidase activity in serum, which was measured using a newly synthesized substrate, (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide, was significantly lower in patients with advanced rheumatoid arthritis or with systemic lupus erythematosus than that in normal controls. Decrease of the serum enzyme activity was more pronounced in systemic lupus erythematosus. No significant change in serum CL-peptidase activity was found in other connective tissue diseases such as mixed connective tissue disease and Sjogren's syndrome.

Original language	English
Pages (from-to)	75-79
Number of pages	5
Journal	Clinica Chimica Acta
Volume	146
Issue number	1
DOIs	https://doi.org/10.1016/0009-8981(85)90125-1
Publication status	Published - 28-02-1985

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All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Biochemistry
Biochemistry, medical

Cite this

Kimi, I. O., Toshiharu, N., Keisuke, F., Katsutaka, T., Tatsuo, H., Tsunehiro, S., Yoshimasa, M., & Shumpei, S. (1985). Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus. Clinica Chimica Acta, 146(1), 75-79. https://doi.org/10.1016/0009-8981(85)90125-1

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abstract = "Collagenase-like(CL) peptidase activity in serum, which was measured using a newly synthesized substrate, (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide, was significantly lower in patients with advanced rheumatoid arthritis or with systemic lupus erythematosus than that in normal controls. Decrease of the serum enzyme activity was more pronounced in systemic lupus erythematosus. No significant change in serum CL-peptidase activity was found in other connective tissue diseases such as mixed connective tissue disease and Sjogren's syndrome.",

author = "Kimi, {Iwase Okadaa} and Nagatsua Toshiharu and Fujita Keisuke and Torikai Katsutaka and Hamamoto Tatsuo and Shibata Tsunehiro and Maeno Yoshimasa and Sakakibara Shumpei",

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Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus. / Kimi, Iwase Okadaa; Toshiharu, Nagatsua; Keisuke, Fujita; Katsutaka, Torikai; Tatsuo, Hamamoto; Tsunehiro, Shibata; Yoshimasa, Maeno; Shumpei, Sakakibara.

In: Clinica Chimica Acta, Vol. 146, No. 1, 28.02.1985, p. 75-79.

Research output: Contribution to journal › Article

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T1 - Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus

AU - Kimi, Iwase Okadaa

AU - Toshiharu, Nagatsua

AU - Keisuke, Fujita

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AU - Tatsuo, Hamamoto

AU - Tsunehiro, Shibata

AU - Yoshimasa, Maeno

AU - Shumpei, Sakakibara

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AB - Collagenase-like(CL) peptidase activity in serum, which was measured using a newly synthesized substrate, (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide, was significantly lower in patients with advanced rheumatoid arthritis or with systemic lupus erythematosus than that in normal controls. Decrease of the serum enzyme activity was more pronounced in systemic lupus erythematosus. No significant change in serum CL-peptidase activity was found in other connective tissue diseases such as mixed connective tissue disease and Sjogren's syndrome.

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10.1016/0009-8981(85)90125-1