Serum concentration of lidocaine after transversus abdominis plane block

Naoko Kato, Yoshihiro Fujiwara, Misako Harato, Shuji Kurokawa, Yasuyuki Shibata, Jun Harada, Toru Komatsu

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)

Abstract

We measured the serum concentration of lidocaine after transversus abdominis plane (TAP) block with 40 ml of 1% lidocaine in 12 patients under general anesthesia, using a fluorescence polarization immunoassay. The peak mean serum concentration of lidocaine occurred 30 min after the block (3.6 ± 0.7 μg·ml-1). The highest concentration of lidocaine (5.5μg·ml-1) was recorded 15 min after the block. These results indicate that a TAP block can potentially cause systemic toxicity of a local anesthetic. The analgesic effect of the TAP block may partially depend on the rise in serum concentration of the local anesthetic.

Original languageEnglish
Pages (from-to)298-300
Number of pages3
JournalJournal of Anesthesia
Volume23
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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