Serum concentrations of carotenoids, α-tocopherol, fatty acids, and lipid peroxides among Japanese in Japan, and Japanese and Caucasians in the US

Yoshinori Ito, H. Shimizu, T. Yoshimura, R. K. Ross, M. Kabuto, N. Takatsuka, N. Tokui, Koji Suzuki, R. Shinohara

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Serum concentrations of carotenoids, α-tocopherol, fatty acids, and thiobarbituric acid-reactive substances (TBARS) were measured in 217 Japanese residents of Japan, and in 99 Japanese and 100 Caucasian residents of the US, aged from 50 y to 74 y. In females, serum values of carotenoids such as β-carotene (BC) and zeaxanthin and lutein (ZL) were highest among Japanese in Japan, followed by Japanese in the US and Caucasians in the US. In males, these values, except for serum BC values, were also highest among Japanese in Japan. Moreover, serum values of n-3 polyunsaturated fatty acids (n-3PUFAs) such as eicosapentaenoic acid and docosa-hexaenoic acid were significantly higher among Japanese in Japan than among Japanese and Caucasians in the US in both sexes. In contrast, serum values of n-6 polyunsaturated fatty acids such as linoleic acid and arachidonic acid were lowest among Japanese in Japan. For women, serum levels of n-9 unsaturated fatty acids were lowest among Japanese living in Japan. Serum TBARS values were highest among Japanese in Japan, followed by Japanese in the US and Caucasians in the US. A significant positive correlation was observed between serum values of TBARS and n-3 PUFAs among Japanese both in Japan and in the US. Serum TBARS values showed a significant inverse relationship with the serum values of BC and ZL among Japanese in Japan and with those of BC among Japanese in the US. These relationships were not always observed among Caucasians in the US. The results of this study suggest that the high TBARS values among Japanese in Japan may depend in part on lipid peroxidation induced in vitro by n-3PUFAs, while high reduction of lipid peroxidation could be expected among Japanese in Japan with high antioxidants such as BC and ZL. In conclusion, serum levels of nonprovitamin A carotenoids such as ZL may be a useful intake marker of vegetables. Dietary intakes of dark green vegetables and fish rich in n-3PUFAs might be more important in the prevention of some sites of cancer and of ischemic heart disease.

Original languageEnglish
Pages (from-to)385-395
Number of pages11
JournalInternational Journal for Vitamin and Nutrition Research
Volume69
Issue number6
DOIs
Publication statusPublished - 01-01-1999

Fingerprint

Tocopherols
Lipid Peroxides
Carotenoids
Japan
Fatty Acids
Thiobarbituric Acid Reactive Substances
Serum
Lutein
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Vegetables
Lipid Peroxidation
Eicosapentaenoic Acid
Linoleic Acid
Arachidonic Acid
Myocardial Ischemia
Fishes
Antioxidants

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Ito, Yoshinori ; Shimizu, H. ; Yoshimura, T. ; Ross, R. K. ; Kabuto, M. ; Takatsuka, N. ; Tokui, N. ; Suzuki, Koji ; Shinohara, R. / Serum concentrations of carotenoids, α-tocopherol, fatty acids, and lipid peroxides among Japanese in Japan, and Japanese and Caucasians in the US. In: International Journal for Vitamin and Nutrition Research. 1999 ; Vol. 69, No. 6. pp. 385-395.
@article{a5696762e118489b8c35d5b77453f98d,
title = "Serum concentrations of carotenoids, α-tocopherol, fatty acids, and lipid peroxides among Japanese in Japan, and Japanese and Caucasians in the US",
abstract = "Serum concentrations of carotenoids, α-tocopherol, fatty acids, and thiobarbituric acid-reactive substances (TBARS) were measured in 217 Japanese residents of Japan, and in 99 Japanese and 100 Caucasian residents of the US, aged from 50 y to 74 y. In females, serum values of carotenoids such as β-carotene (BC) and zeaxanthin and lutein (ZL) were highest among Japanese in Japan, followed by Japanese in the US and Caucasians in the US. In males, these values, except for serum BC values, were also highest among Japanese in Japan. Moreover, serum values of n-3 polyunsaturated fatty acids (n-3PUFAs) such as eicosapentaenoic acid and docosa-hexaenoic acid were significantly higher among Japanese in Japan than among Japanese and Caucasians in the US in both sexes. In contrast, serum values of n-6 polyunsaturated fatty acids such as linoleic acid and arachidonic acid were lowest among Japanese in Japan. For women, serum levels of n-9 unsaturated fatty acids were lowest among Japanese living in Japan. Serum TBARS values were highest among Japanese in Japan, followed by Japanese in the US and Caucasians in the US. A significant positive correlation was observed between serum values of TBARS and n-3 PUFAs among Japanese both in Japan and in the US. Serum TBARS values showed a significant inverse relationship with the serum values of BC and ZL among Japanese in Japan and with those of BC among Japanese in the US. These relationships were not always observed among Caucasians in the US. The results of this study suggest that the high TBARS values among Japanese in Japan may depend in part on lipid peroxidation induced in vitro by n-3PUFAs, while high reduction of lipid peroxidation could be expected among Japanese in Japan with high antioxidants such as BC and ZL. In conclusion, serum levels of nonprovitamin A carotenoids such as ZL may be a useful intake marker of vegetables. Dietary intakes of dark green vegetables and fish rich in n-3PUFAs might be more important in the prevention of some sites of cancer and of ischemic heart disease.",
author = "Yoshinori Ito and H. Shimizu and T. Yoshimura and Ross, {R. K.} and M. Kabuto and N. Takatsuka and N. Tokui and Koji Suzuki and R. Shinohara",
year = "1999",
month = "1",
day = "1",
doi = "10.1024/0300-9831.69.6.385",
language = "English",
volume = "69",
pages = "385--395",
journal = "Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie",
issn = "0300-9831",
publisher = "Verlag Hans Huber",
number = "6",

}

Serum concentrations of carotenoids, α-tocopherol, fatty acids, and lipid peroxides among Japanese in Japan, and Japanese and Caucasians in the US. / Ito, Yoshinori; Shimizu, H.; Yoshimura, T.; Ross, R. K.; Kabuto, M.; Takatsuka, N.; Tokui, N.; Suzuki, Koji; Shinohara, R.

In: International Journal for Vitamin and Nutrition Research, Vol. 69, No. 6, 01.01.1999, p. 385-395.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum concentrations of carotenoids, α-tocopherol, fatty acids, and lipid peroxides among Japanese in Japan, and Japanese and Caucasians in the US

AU - Ito, Yoshinori

AU - Shimizu, H.

AU - Yoshimura, T.

AU - Ross, R. K.

AU - Kabuto, M.

AU - Takatsuka, N.

AU - Tokui, N.

AU - Suzuki, Koji

AU - Shinohara, R.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Serum concentrations of carotenoids, α-tocopherol, fatty acids, and thiobarbituric acid-reactive substances (TBARS) were measured in 217 Japanese residents of Japan, and in 99 Japanese and 100 Caucasian residents of the US, aged from 50 y to 74 y. In females, serum values of carotenoids such as β-carotene (BC) and zeaxanthin and lutein (ZL) were highest among Japanese in Japan, followed by Japanese in the US and Caucasians in the US. In males, these values, except for serum BC values, were also highest among Japanese in Japan. Moreover, serum values of n-3 polyunsaturated fatty acids (n-3PUFAs) such as eicosapentaenoic acid and docosa-hexaenoic acid were significantly higher among Japanese in Japan than among Japanese and Caucasians in the US in both sexes. In contrast, serum values of n-6 polyunsaturated fatty acids such as linoleic acid and arachidonic acid were lowest among Japanese in Japan. For women, serum levels of n-9 unsaturated fatty acids were lowest among Japanese living in Japan. Serum TBARS values were highest among Japanese in Japan, followed by Japanese in the US and Caucasians in the US. A significant positive correlation was observed between serum values of TBARS and n-3 PUFAs among Japanese both in Japan and in the US. Serum TBARS values showed a significant inverse relationship with the serum values of BC and ZL among Japanese in Japan and with those of BC among Japanese in the US. These relationships were not always observed among Caucasians in the US. The results of this study suggest that the high TBARS values among Japanese in Japan may depend in part on lipid peroxidation induced in vitro by n-3PUFAs, while high reduction of lipid peroxidation could be expected among Japanese in Japan with high antioxidants such as BC and ZL. In conclusion, serum levels of nonprovitamin A carotenoids such as ZL may be a useful intake marker of vegetables. Dietary intakes of dark green vegetables and fish rich in n-3PUFAs might be more important in the prevention of some sites of cancer and of ischemic heart disease.

AB - Serum concentrations of carotenoids, α-tocopherol, fatty acids, and thiobarbituric acid-reactive substances (TBARS) were measured in 217 Japanese residents of Japan, and in 99 Japanese and 100 Caucasian residents of the US, aged from 50 y to 74 y. In females, serum values of carotenoids such as β-carotene (BC) and zeaxanthin and lutein (ZL) were highest among Japanese in Japan, followed by Japanese in the US and Caucasians in the US. In males, these values, except for serum BC values, were also highest among Japanese in Japan. Moreover, serum values of n-3 polyunsaturated fatty acids (n-3PUFAs) such as eicosapentaenoic acid and docosa-hexaenoic acid were significantly higher among Japanese in Japan than among Japanese and Caucasians in the US in both sexes. In contrast, serum values of n-6 polyunsaturated fatty acids such as linoleic acid and arachidonic acid were lowest among Japanese in Japan. For women, serum levels of n-9 unsaturated fatty acids were lowest among Japanese living in Japan. Serum TBARS values were highest among Japanese in Japan, followed by Japanese in the US and Caucasians in the US. A significant positive correlation was observed between serum values of TBARS and n-3 PUFAs among Japanese both in Japan and in the US. Serum TBARS values showed a significant inverse relationship with the serum values of BC and ZL among Japanese in Japan and with those of BC among Japanese in the US. These relationships were not always observed among Caucasians in the US. The results of this study suggest that the high TBARS values among Japanese in Japan may depend in part on lipid peroxidation induced in vitro by n-3PUFAs, while high reduction of lipid peroxidation could be expected among Japanese in Japan with high antioxidants such as BC and ZL. In conclusion, serum levels of nonprovitamin A carotenoids such as ZL may be a useful intake marker of vegetables. Dietary intakes of dark green vegetables and fish rich in n-3PUFAs might be more important in the prevention of some sites of cancer and of ischemic heart disease.

UR - http://www.scopus.com/inward/record.url?scp=0033226383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033226383&partnerID=8YFLogxK

U2 - 10.1024/0300-9831.69.6.385

DO - 10.1024/0300-9831.69.6.385

M3 - Article

C2 - 10642896

AN - SCOPUS:0033226383

VL - 69

SP - 385

EP - 395

JO - Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie

JF - Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie

SN - 0300-9831

IS - 6

ER -