Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction

Junichi Ishii, J. Wang, H. Naruse, S. Taga, M. Kinoshita, H. Kurokawa, M. Iwase, T. Kondo, M. Nomura, Y. Nagamura, Y. Watanabe, H. Hishida, T. Tanaka, K. Kawamura

Research output: Contribution to journalArticle

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Abstract

We compared the diagnostic utility of serum concentrations of human heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin, and their ratio for the early diagnosis of acute myocardial infarction (AMI) in 104 healthy volunteers and 165 patients at admission within 6 h of the onset of chest pain. The ROC curves of the H-FABPc [0.946, 95% confidence interval (CI) = 0.913-0.979] and myoglobin (0.895, 95% CI = 0.8460.944) between patients with AMI and healthy volunteers were significantly greater than the area under the ratio of myoglobin to H-FABPc (0.823, 95% CI = 0.7650.881). In 165 patients, the sensitivity (81.8%, 95% CI = 74.2-89.4%), specificity (86.4%, 95% CI = 78.1-94.6%), and predictive accuracy (83.6%, 95% CI = 78.0- 89.3%) of H-FABPc >12 μg/L in, diagnosing AMI were significantly higher than those of myoglobin, and were similar to those of the combination of H-FABFc >12 μg/L and the ratio ≤14. We conclude that H-FABPc is a more sensitive and specific marker than myoglobin for the early diagnosis of AMI, and that their ratio cannot give a clear advantage over the measurement of H-FABPc alone.

Original languageEnglish
Pages (from-to)1372-1378
Number of pages7
JournalClinical Chemistry
Volume43
Issue number8
Publication statusPublished - 19-08-1997

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Fatty Acid-Binding Proteins
Myoglobin
Myocardial Infarction
Confidence Intervals
Serum
Early Diagnosis
Healthy Volunteers
Patient Admission
Chest Pain
ROC Curve
human FABP3 protein

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ishii, Junichi ; Wang, J. ; Naruse, H. ; Taga, S. ; Kinoshita, M. ; Kurokawa, H. ; Iwase, M. ; Kondo, T. ; Nomura, M. ; Nagamura, Y. ; Watanabe, Y. ; Hishida, H. ; Tanaka, T. ; Kawamura, K. / Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction. In: Clinical Chemistry. 1997 ; Vol. 43, No. 8. pp. 1372-1378.
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title = "Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction",
abstract = "We compared the diagnostic utility of serum concentrations of human heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin, and their ratio for the early diagnosis of acute myocardial infarction (AMI) in 104 healthy volunteers and 165 patients at admission within 6 h of the onset of chest pain. The ROC curves of the H-FABPc [0.946, 95{\%} confidence interval (CI) = 0.913-0.979] and myoglobin (0.895, 95{\%} CI = 0.8460.944) between patients with AMI and healthy volunteers were significantly greater than the area under the ratio of myoglobin to H-FABPc (0.823, 95{\%} CI = 0.7650.881). In 165 patients, the sensitivity (81.8{\%}, 95{\%} CI = 74.2-89.4{\%}), specificity (86.4{\%}, 95{\%} CI = 78.1-94.6{\%}), and predictive accuracy (83.6{\%}, 95{\%} CI = 78.0- 89.3{\%}) of H-FABPc >12 μg/L in, diagnosing AMI were significantly higher than those of myoglobin, and were similar to those of the combination of H-FABFc >12 μg/L and the ratio ≤14. We conclude that H-FABPc is a more sensitive and specific marker than myoglobin for the early diagnosis of AMI, and that their ratio cannot give a clear advantage over the measurement of H-FABPc alone.",
author = "Junichi Ishii and J. Wang and H. Naruse and S. Taga and M. Kinoshita and H. Kurokawa and M. Iwase and T. Kondo and M. Nomura and Y. Nagamura and Y. Watanabe and H. Hishida and T. Tanaka and K. Kawamura",
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Ishii, J, Wang, J, Naruse, H, Taga, S, Kinoshita, M, Kurokawa, H, Iwase, M, Kondo, T, Nomura, M, Nagamura, Y, Watanabe, Y, Hishida, H, Tanaka, T & Kawamura, K 1997, 'Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction', Clinical Chemistry, vol. 43, no. 8, pp. 1372-1378.

Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction. / Ishii, Junichi; Wang, J.; Naruse, H.; Taga, S.; Kinoshita, M.; Kurokawa, H.; Iwase, M.; Kondo, T.; Nomura, M.; Nagamura, Y.; Watanabe, Y.; Hishida, H.; Tanaka, T.; Kawamura, K.

In: Clinical Chemistry, Vol. 43, No. 8, 19.08.1997, p. 1372-1378.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction

AU - Ishii, Junichi

AU - Wang, J.

AU - Naruse, H.

AU - Taga, S.

AU - Kinoshita, M.

AU - Kurokawa, H.

AU - Iwase, M.

AU - Kondo, T.

AU - Nomura, M.

AU - Nagamura, Y.

AU - Watanabe, Y.

AU - Hishida, H.

AU - Tanaka, T.

AU - Kawamura, K.

PY - 1997/8/19

Y1 - 1997/8/19

N2 - We compared the diagnostic utility of serum concentrations of human heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin, and their ratio for the early diagnosis of acute myocardial infarction (AMI) in 104 healthy volunteers and 165 patients at admission within 6 h of the onset of chest pain. The ROC curves of the H-FABPc [0.946, 95% confidence interval (CI) = 0.913-0.979] and myoglobin (0.895, 95% CI = 0.8460.944) between patients with AMI and healthy volunteers were significantly greater than the area under the ratio of myoglobin to H-FABPc (0.823, 95% CI = 0.7650.881). In 165 patients, the sensitivity (81.8%, 95% CI = 74.2-89.4%), specificity (86.4%, 95% CI = 78.1-94.6%), and predictive accuracy (83.6%, 95% CI = 78.0- 89.3%) of H-FABPc >12 μg/L in, diagnosing AMI were significantly higher than those of myoglobin, and were similar to those of the combination of H-FABFc >12 μg/L and the ratio ≤14. We conclude that H-FABPc is a more sensitive and specific marker than myoglobin for the early diagnosis of AMI, and that their ratio cannot give a clear advantage over the measurement of H-FABPc alone.

AB - We compared the diagnostic utility of serum concentrations of human heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin, and their ratio for the early diagnosis of acute myocardial infarction (AMI) in 104 healthy volunteers and 165 patients at admission within 6 h of the onset of chest pain. The ROC curves of the H-FABPc [0.946, 95% confidence interval (CI) = 0.913-0.979] and myoglobin (0.895, 95% CI = 0.8460.944) between patients with AMI and healthy volunteers were significantly greater than the area under the ratio of myoglobin to H-FABPc (0.823, 95% CI = 0.7650.881). In 165 patients, the sensitivity (81.8%, 95% CI = 74.2-89.4%), specificity (86.4%, 95% CI = 78.1-94.6%), and predictive accuracy (83.6%, 95% CI = 78.0- 89.3%) of H-FABPc >12 μg/L in, diagnosing AMI were significantly higher than those of myoglobin, and were similar to those of the combination of H-FABFc >12 μg/L and the ratio ≤14. We conclude that H-FABPc is a more sensitive and specific marker than myoglobin for the early diagnosis of AMI, and that their ratio cannot give a clear advantage over the measurement of H-FABPc alone.

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