Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction

J. Ishii, J. Wang, H. Naruse, S. Taga, M. Kinoshita, H. Kurokawa, M. Iwase, T. Kondo, M. Nomura, Y. Nagamura, Y. Watanabe, H. Hishida, T. Tanaka, K. Kawamura

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Abstract

We compared the diagnostic utility of serum concentrations of human heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin, and their ratio for the early diagnosis of acute myocardial infarction (AMI) in 104 healthy volunteers and 165 patients at admission within 6 h of the onset of chest pain. The ROC curves of the H-FABPc [0.946, 95% confidence interval (CI) = 0.913-0.979] and myoglobin (0.895, 95% CI = 0.8460.944) between patients with AMI and healthy volunteers were significantly greater than the area under the ratio of myoglobin to H-FABPc (0.823, 95% CI = 0.7650.881). In 165 patients, the sensitivity (81.8%, 95% CI = 74.2-89.4%), specificity (86.4%, 95% CI = 78.1-94.6%), and predictive accuracy (83.6%, 95% CI = 78.0- 89.3%) of H-FABPc >12 μg/L in, diagnosing AMI were significantly higher than those of myoglobin, and were similar to those of the combination of H-FABFc >12 μg/L and the ratio ≤14. We conclude that H-FABPc is a more sensitive and specific marker than myoglobin for the early diagnosis of AMI, and that their ratio cannot give a clear advantage over the measurement of H-FABPc alone.

Original languageEnglish
Pages (from-to)1372-1378
Number of pages7
JournalClinical Chemistry
Volume43
Issue number8
Publication statusPublished - 19-08-1997

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

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    Ishii, J., Wang, J., Naruse, H., Taga, S., Kinoshita, M., Kurokawa, H., Iwase, M., Kondo, T., Nomura, M., Nagamura, Y., Watanabe, Y., Hishida, H., Tanaka, T., & Kawamura, K. (1997). Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction. Clinical Chemistry, 43(8), 1372-1378.