Serum cystatin C level is associated with locomotive syndrome risk and can be an early predictor in community-living people

The Yakumo study

Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Taisuke Seki, Koji Suzuki, Yoshihiro Nishida, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: The locomotive syndrome (LS) risk has been recently proposed as a criterion for evaluating physical ability. Serum cystatin C level is an early renal function marker and a cardiovascular disease predictor. This study aimed to evaluate the relationship between serum cystatin C level and LS risk. Methods: We enrolled 54 participants and conducted the two-step test, stand-up test, 25-question geriatric locomotive function scale, LS risk test, Timed Up and Go test, back muscle strength, grip strength, blood test and serum cystatin C level measurement. A comparative study was conducted in participants with and without LS risk and in subgroups aged <60 and ≥60 years. Results: No significant difference was found in the serum cystatin C level in subgroups aged <60 years and without LS risk. However, it was significantly higher in subjects with LS risk and aged ≥60 years. The area under the curve of the serum cystatin C level for LS risk was 0.824. Conclusion: The serum cystatin C level is significantly related to LS risk and can be an early predictor. In middle-aged and elderly people with high serum cystatin C levels, it is strongly recommended to enforce LS risk test and intervention.

Original languageEnglish
Pages (from-to)1035-1040
Number of pages6
JournalModern Rheumatology
Volume28
Issue number6
DOIs
Publication statusPublished - 02-11-2018

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Cystatin C
Serum
Back Muscles
Muscle Strength
Hematologic Tests
Hand Strength
Exercise Test
Geriatrics
Area Under Curve
Cardiovascular Diseases
Kidney

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Tanaka, Satoshi ; Ando, Kei ; Kobayashi, Kazuyoshi ; Hida, Tetsuro ; Ito, Kenyu ; Tsushima, Mikito ; Morozumi, Masayoshi ; Machino, Masaaki ; Ota, Kyotaro ; Seki, Taisuke ; Suzuki, Koji ; Nishida, Yoshihiro ; Ishiguro, Naoki ; Hasegawa, Yukiharu ; Imagama, Shiro. / Serum cystatin C level is associated with locomotive syndrome risk and can be an early predictor in community-living people : The Yakumo study. In: Modern Rheumatology. 2018 ; Vol. 28, No. 6. pp. 1035-1040.
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abstract = "Objectives: The locomotive syndrome (LS) risk has been recently proposed as a criterion for evaluating physical ability. Serum cystatin C level is an early renal function marker and a cardiovascular disease predictor. This study aimed to evaluate the relationship between serum cystatin C level and LS risk. Methods: We enrolled 54 participants and conducted the two-step test, stand-up test, 25-question geriatric locomotive function scale, LS risk test, Timed Up and Go test, back muscle strength, grip strength, blood test and serum cystatin C level measurement. A comparative study was conducted in participants with and without LS risk and in subgroups aged <60 and ≥60 years. Results: No significant difference was found in the serum cystatin C level in subgroups aged <60 years and without LS risk. However, it was significantly higher in subjects with LS risk and aged ≥60 years. The area under the curve of the serum cystatin C level for LS risk was 0.824. Conclusion: The serum cystatin C level is significantly related to LS risk and can be an early predictor. In middle-aged and elderly people with high serum cystatin C levels, it is strongly recommended to enforce LS risk test and intervention.",
author = "Satoshi Tanaka and Kei Ando and Kazuyoshi Kobayashi and Tetsuro Hida and Kenyu Ito and Mikito Tsushima and Masayoshi Morozumi and Masaaki Machino and Kyotaro Ota and Taisuke Seki and Koji Suzuki and Yoshihiro Nishida and Naoki Ishiguro and Yukiharu Hasegawa and Shiro Imagama",
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Tanaka, S, Ando, K, Kobayashi, K, Hida, T, Ito, K, Tsushima, M, Morozumi, M, Machino, M, Ota, K, Seki, T, Suzuki, K, Nishida, Y, Ishiguro, N, Hasegawa, Y & Imagama, S 2018, 'Serum cystatin C level is associated with locomotive syndrome risk and can be an early predictor in community-living people: The Yakumo study', Modern Rheumatology, vol. 28, no. 6, pp. 1035-1040. https://doi.org/10.1080/14397595.2018.1441675

Serum cystatin C level is associated with locomotive syndrome risk and can be an early predictor in community-living people : The Yakumo study. / Tanaka, Satoshi; Ando, Kei; Kobayashi, Kazuyoshi; Hida, Tetsuro; Ito, Kenyu; Tsushima, Mikito; Morozumi, Masayoshi; Machino, Masaaki; Ota, Kyotaro; Seki, Taisuke; Suzuki, Koji; Nishida, Yoshihiro; Ishiguro, Naoki; Hasegawa, Yukiharu; Imagama, Shiro.

In: Modern Rheumatology, Vol. 28, No. 6, 02.11.2018, p. 1035-1040.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum cystatin C level is associated with locomotive syndrome risk and can be an early predictor in community-living people

T2 - The Yakumo study

AU - Tanaka, Satoshi

AU - Ando, Kei

AU - Kobayashi, Kazuyoshi

AU - Hida, Tetsuro

AU - Ito, Kenyu

AU - Tsushima, Mikito

AU - Morozumi, Masayoshi

AU - Machino, Masaaki

AU - Ota, Kyotaro

AU - Seki, Taisuke

AU - Suzuki, Koji

AU - Nishida, Yoshihiro

AU - Ishiguro, Naoki

AU - Hasegawa, Yukiharu

AU - Imagama, Shiro

PY - 2018/11/2

Y1 - 2018/11/2

N2 - Objectives: The locomotive syndrome (LS) risk has been recently proposed as a criterion for evaluating physical ability. Serum cystatin C level is an early renal function marker and a cardiovascular disease predictor. This study aimed to evaluate the relationship between serum cystatin C level and LS risk. Methods: We enrolled 54 participants and conducted the two-step test, stand-up test, 25-question geriatric locomotive function scale, LS risk test, Timed Up and Go test, back muscle strength, grip strength, blood test and serum cystatin C level measurement. A comparative study was conducted in participants with and without LS risk and in subgroups aged <60 and ≥60 years. Results: No significant difference was found in the serum cystatin C level in subgroups aged <60 years and without LS risk. However, it was significantly higher in subjects with LS risk and aged ≥60 years. The area under the curve of the serum cystatin C level for LS risk was 0.824. Conclusion: The serum cystatin C level is significantly related to LS risk and can be an early predictor. In middle-aged and elderly people with high serum cystatin C levels, it is strongly recommended to enforce LS risk test and intervention.

AB - Objectives: The locomotive syndrome (LS) risk has been recently proposed as a criterion for evaluating physical ability. Serum cystatin C level is an early renal function marker and a cardiovascular disease predictor. This study aimed to evaluate the relationship between serum cystatin C level and LS risk. Methods: We enrolled 54 participants and conducted the two-step test, stand-up test, 25-question geriatric locomotive function scale, LS risk test, Timed Up and Go test, back muscle strength, grip strength, blood test and serum cystatin C level measurement. A comparative study was conducted in participants with and without LS risk and in subgroups aged <60 and ≥60 years. Results: No significant difference was found in the serum cystatin C level in subgroups aged <60 years and without LS risk. However, it was significantly higher in subjects with LS risk and aged ≥60 years. The area under the curve of the serum cystatin C level for LS risk was 0.824. Conclusion: The serum cystatin C level is significantly related to LS risk and can be an early predictor. In middle-aged and elderly people with high serum cystatin C levels, it is strongly recommended to enforce LS risk test and intervention.

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