TY - JOUR
T1 - SERUM DOPAMINE‐β‐HYDROXYLASE IN SCHIZOPHRENIC PATIENTS
AU - Fujita, K.
AU - Ito, T.
AU - Maruta, K.
AU - Teradaira, R.
AU - Beppu, H.
AU - Nakacami, Y.
AU - Kato, Y.
AU - Nagatsu, T.
AU - Kato, T.
PY - 1978/6
Y1 - 1978/6
N2 - Abstract— Dopamine‐β‐hydroxylase (DBH) activity in serum was decreased significantly in schizophrenic patients (16.17 ± 12.60 μmol/min/1 of serum, mean ± S.D., n = 149) when compared with that of normal controls (42.53 ± 30.94 μmol/min/1 of serum, mean ± S.D., n= 153) and neurotic patients. Long duration of disease did not cause any significant changes in serum DBH activity except a tendency for increase in patients of lodger than 18 years duration. We also examined the possibility that the serum DBH deficiency in the schizophrenic group was an artifact of treatment with antipsychotic drugs, especially phenothiazines. No significant difference was observed between the patients treated with the drugs and the patients not receiving the drugs.
AB - Abstract— Dopamine‐β‐hydroxylase (DBH) activity in serum was decreased significantly in schizophrenic patients (16.17 ± 12.60 μmol/min/1 of serum, mean ± S.D., n = 149) when compared with that of normal controls (42.53 ± 30.94 μmol/min/1 of serum, mean ± S.D., n= 153) and neurotic patients. Long duration of disease did not cause any significant changes in serum DBH activity except a tendency for increase in patients of lodger than 18 years duration. We also examined the possibility that the serum DBH deficiency in the schizophrenic group was an artifact of treatment with antipsychotic drugs, especially phenothiazines. No significant difference was observed between the patients treated with the drugs and the patients not receiving the drugs.
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U2 - 10.1111/j.1471-4159.1978.tb10494.x
DO - 10.1111/j.1471-4159.1978.tb10494.x
M3 - Article
C2 - 670998
AN - SCOPUS:0018174414
SN - 0022-3042
VL - 30
SP - 1569
EP - 1572
JO - Journal of neurochemistry
JF - Journal of neurochemistry
IS - 6
ER -